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Rapid Communication:Acute Renal Failure Associated with Tenofovir: Evidence of Drug-Induced Nephrotoxicity |
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The American Journal of the Medical Sciences,
Volume 324,
Issue 6,
2002,
Page 342-344
Steven Coca,
Mark Perazella,
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PDF (281KB)
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摘要:
Drug-induced renal failure is a relatively common event in patients infected with HIV. This group of patients receives a number of potentially nephrotoxic medications for a variety of illnesses. The acyclic nucleoside phosphonates cidofovir and adefovir are antivirals that possess significant nephrotoxicity. Interestingly, tenofovir disoproxil fumurate (DF) is structurally similar to these 2 agents, yet seems to be less nephrotoxic based on a few published studies in HIV patients with intact renal function. We present a case in which acute renal failure developed after therapy with tenofovir DF in a patient with HIV and stable chronic kidney disease.
ISSN:0002-9629
出版商:OVID
年代:2002
数据来源: OVID
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