摘要:

Pancreatic alpha and beta cell hormone secretion was studied in 11 patients with thyrotoxicosis before and in 7 patients after thyroid function was normalized with either prophylthiouracil or methimazole and propranolol (R). All had IV arginine and IV glucose infusions. Forty control subjects had IV arginine; 21 had IV glucose tests. After arginine, untreated patient had blunted serum insulin at both 15 and 30 minutes (p<0.05, p<0.001) compared to control subjects, blunted glucagon at 30 minutes (p<0.05) and blunted glucose at both 15 and 30 minutes (p<0.001, p<0.01) compared to control subjects. After glucose, untreated patients had lower nadir glucagon than in the studies with both arginine and glucose infusions. These data document blunted glucagon, suppressed glucose and insulin peaks after arginine in thyrotoxicosis, indicate that both alpha and beta cell hormone secretion may be abnormal, and that the preferential abnormality follows protein rather than carbohydrate loading.

ISSN:0002-9629    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Renomedullary prostaglandin synthesis is lower in salt-sensitive (S) Dahl rats than in age-matched salt-resistant (R) rats on either 0.6% or 8.0% NaCl. The possible role of substrate availability to the cyclooxygenase in determining these differences was examined. S and R rats were started on diets with variable salt content (0.6%, 4.0% or 8.0% NaCl) at five weeks and were sacrified at either 11 or 16 weeks of age for comparisons of renomedullary phosphollpase A1and A2activities (EC 3.1.1.4. and 3.1.1.32) and arachidonate incorporation into the lipids of renal medulla. Both phospholipase activities were higher in R rats at the two ages examined and for all levels of salt intake. These differences could not be accounted for by variable amounts of endogenous phospholipid substrate. High salt intake did not influence the in vitro A2deacylating activities per mg protein. Arachidonate incorporation into renomedullary triglycerides remained constant with age in both strains while phospholipid labeling declined with age in S rats only so that, at 16 weeks of age, S rats had significantly lower incorporation into membrane phospholipids. This age-related decline in phospholipid labeling in S rats was prevented by 4.0% NaCl. These results suggest that low renomedullary phospholipase activities in S rats may restrict the release of substrate for prostaglandin synthesis and may also be related to reduced rates of fatty acid incorporation into membrane phospholipids.

ISSN:0002-9629    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

The contractile performance of isolated muscle preparations from the left ventricle of rats receiving a 3% casein protein deficient diet for two to three weeks was compared with the performance of muscle preparations from animals receiving a normal diet. The right and left ventricular weights from protein deficient animals were significantly decreased, but left ventricle/body weight and right ventricular/body weight ratios did not differ from control animals. The performance of the isolated muscle preparations revealed no differences in the following parameters measured at the apex of the length tension curve: peak active tension, resting tension, maximum rate of tension development and time to peak tension. RT1/2, an index of relaxation, and maximum rate of tension decline indicated relaxation rate was increased in preparations from protein deficient animals. We conclude that, while a protein deficient diet of two to three weeks duration results in proportionate decreases in body and cardiac chamber weight in comparison to control animals, no evidence for impaired contractile activity is seen.

ISSN:0002-9629    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Granulocytic sarcoma, or chloroma, rarely occurs in the anterior mediastinum. When it does, the clinical picture may resemble lymphoma. We report two patients in whom evaluation for mediastinal mass revealed the diagnosis of granulocytic sarcoma. In both patients, careful histopathologic evaluation with the aid of special stains confirmed the granulocytic origin of these tumors.

ISSN:0002-9629    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Cardiac hemochromatosis usually presents with clinical congestive heart failure and an enlarged heart. A woman with secondary hemochromatosis and features of both restrictive and congestive cardiomyopathy with a normal sized heart is described. Despite all interventions she had progressive cardiac impairment and expired eight days following presentation. The clinical and laboratory findings of 49 cases of cardiac hemochromatosis during the last 50 years are reviewed. While the disease usually progresses slowly, a significant minority die within fourteen days of recognition. Not infrequently pericardial tamponade is entertained as a cause for this rapid deterioration; however, both a restrictive and congestive cardiomyopathy appear to be responsible for this catastrophic presentation.

ISSN:0002-9629    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

The availability of easy to use microcomputers and medical information retrieval systems will result in fundamental and important changes in medical practice. The acquisition of information literacy and fluency will be mandatory techniques for the future practice of medicine and should be taught at the institutional level by faculty sophisticated in the use of information retrieval systems. The resulting improvements in the practice of medicine go beyond simple cost savings to fundamentally alter the ways patients and their disorders are looked upon and handled.

ISSN:0002-9629    

出版商:OVID    

年代:1985

数据来源: OVID