ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

A prospective study of the etiologies and characteristic features of pneumonias was done at the Milwaukee County General Hospital from October 1969 to March 1970. The study comprised 148 consecutive patients who had received no previous antibiotics.D. pneumoniaewas the etiologic agent in 79 patients (53.0 per cent); 21.6 per cent were bacteremic. According to strict criteria, 9.5 per cent of pneumonias were ascribed to gram-negative bacilli and 7.0 per cent to staphylococci. Primary viral and mycoplasmal infections were diagnosed by complement fixation test in 15.6 per cent of the 77 pneumonia patients from whom paired sera were available. In 17.0 per cent, no etiology could be established.D. pneumoniaepatients with and without bacteremia differed from each other significantly (p<0.05) in mortality (35.0 per centvs13.0 per cent), days febrile before admission (4.1vs2.2), shock (23.0 per centvs4.8 per cent), and lobar pattern (88.2 per centvs52.0 per cent), respectively. In comparing pneumonias of different etiologies, patients with gram-negative bacillary pneumonias were found to be significantly older (70 yr) than those with other pneumonias (56 yr; p<0.01), had a higher mortality (47.0 per centvs13.8 per cent; p<0.01), and tended more often to come from nursing homes (59.0 per centvs28.0 per cent; p<0.05).

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

Humoral responses in tumor immunology have been reviewed in light of past and recent experimental findings. The basic concepts of tumor immunity, both cellular and humoral, did not emerge until tumor-specific transplantation antigens were distinguished from histocompatibility transplantation antigens. Experimental findings have demonstrated the presence of tumor-specific and/or associated antigens in both chemically induced as well as spontaneously arising tumors. The antigens resulting from chemical induction have been found to possess individual specificity while those from spontaneous tumors displayed cross-reacting antigenic reactivity. Cellular and humoral factors are both inherent in the framework of tumor immunology. Cell-mediated tumor immunity has been only briefly reviewed in this report; emphasis was primarily focused on the humoral aspects. Humoral tumor immunity has been discussed on the basis of the biochemical nature and immunobiological activity of the circulating substances known to date. The use of radiolabeled antibodies in tumor immunology has also been presented from the standpoint of tumor localization and potential therapeutic use. Finally, the utilization of the radioimmunoassay in tumor therapy and diagnostics has been reviewed.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

Alterations in systolic time intervals during standardized cycle ergometer exercise testing were studied in nine normal middle-aged men. The results were related to oxygen uptake as well as cardiac output. Mild exercise (200 kpm min-1) led to no significant shortening of left ventricular ejection time (LVET), whereas the pre-ejection period (PEP) fell sharply (p<0.001). Heavier work rate was associated with a significant shortening of both intervals. The small variations of the normal values in the subjects studied suggest that this may be an appropriate measure of cardiovascular response to physiological stress. Comparison is diagnostically useful in patients whose heart rate response is within normal range. This is illustrated by a patient whose resting values were within normal limits, but exercise led to a greater decrease in LVET than in the normal group, possibly reflecting inability to increase the stroke volume to the expected level at this work rate. The use of systolic time intervals in association with exercise testing may be of use in revealing mild disturbance of myocardial function in patients who may show no evident abnormality at rest.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

Among 147 gram-negative uropathogens, 49 per cent are susceptible to cefazolin, 39 per cent to cephapirin, 32 per cent to cephaloridine, 31 per cent to cephalothin, 19 per cent to cephalexin, 15 per cent to cephadrine, and 0.07 per cent to cephaloglycin. Two thirds ofEscherichia coliare susceptible to cefazolin, 46.5 per cent to cephapirin, and 37 per cent to cephaloridine. Sixty-four per cent ofKlebsiella pneumoniaeare susceptible to cefazolin, 54.5 per cent to cephalexin, and 50 per cent to cephapirin. Half of the indolepositive and 71 per cent of indole-negativeProteusare susceptible to cephalothin. As there is a wide variation among pathogenic bacteria to seven tetracyclines, a similar variation exists among seven cephalosporins. On the basis of these data, it is advisable to test a pathogen against all seven cephalosporins.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

Endocarditis due toActinobacillus actinomycetemcomitansis extremely rare. A case associated with an aneurysm of the sinus of Valsalva is presented together with bacteriologic, angiographic, and pathologic data. The literature is reviewed particularly in regard to clinical features and treatment of this unusual form of endocarditis.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

A case of hyponatremia, serum hypo-osmolality, urine hyperosmolality, with normal renal, hepatic, and cardiac function, and absence of adrenal insufficiency is reported in a patient with a documented metastatic carcinoma of the adrenal. Even though antidiuretic hormone was not assayed, all the criteria described in the syndrome of inappropriate secretion of antidiuretic hormone were met, representing the first so described association with a malignancy of the adrenal gland.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID