ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

Anti-D antibody, both in the form of whole serum or purified γG fraction, inhibited membrane mediated ATP synthesis only in membranes prepared from D-positive erythrocytes. Neither variation in availability of substrates nor direct interference of enzymes by antibody can account for this effect.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

Previous studies have suggested the presence of a lipolytic enzyme in the gastric juice of dogs, rats and humans. However, these studies were inconclusive since no measures were employed to prevent the reflux of duodenal contents into the stomach. We have studied the effect of gastric juice, obtained from dogs with isolated Heidenhain pouches, on the lipolysis of a medium chain triglyceride, trioctanoin, and a long chain triglyceride, tripalmitin. It was clearly demonstrated that canine gastric juice contains a lipase system which hydrolyzes trioctanoin but not tripalmitin. The gastric lipase was about one-tenth as active as pancreatic lipase and had a pH optimum of 6.0 to 7.0 units. Additional studies suggested that the lipolytic activity of gastric juice was not due to pepsin or pancreatic lipase.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

The effect of moderate hypoxia produced by ventilation with gas mixtures containing lowered oxygen concentration on the dose of acetylstrophanthidin required to produce ventricular tachycardia was examined in 16 anesthelized dogs. During hypoxia (average pO2=40 mm Hg) 19% less acetylstrophantuidin was required to produce ventricular tachycardia. The duration of the toxic arrhythmia was not different during ventilation with air or hypoxic gases. The arterial pressure and serum potassium were elevated to similar levels during air and hypoxic ventilation. The hypothetical mechanism which caused the reduced tolerance to acetylstrophanthidin was considered to be related to the effects of hypoxia on cellular sodium-potassium pumping, with resulting changes in the extracellular-intracellular potassium gradient and changes in the binding of intracellular cardiac glycosides. Changes in metabolism and alterations in blood concentration were considered as alternate explanations.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

Twenty-three patients with radiologically enlarged eardinc shadows were studied for the presence of pericardial effusion by taking serial A-P films in the right lateral decubitus position after intravenous injection of radiopaque medium. The distance between the outlined dependent part of the right atrial cavity and the lowermost part of the cardiac silhouette was found to be between 4 and 11 mm in twelve patients who were considered not to have pericardial effusion. In six patients with effusion (proven by pericardiocentesis or biopsy in four) the extra-atrial shadow ranged between 22 and 48 mm. Fibrinous or adhesive pericarditis was found in three with extraluminal bands between 12 and 16 mm. The results of the technique were unsatisfactory in two patients. It was concluded that the method is technically simple and virtually diagnostic of significant pericardial effusion when the extra-atrial thickness is over 20 mm.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

Since some analgesics and relaxants are known to potentiate and many tranquilizers are known to shorten the pharmacologic action of coumarin-type drugs, a study was undertaken to determine the possible effect of chlordiazepoxide HCl (Librium) in patients on long-term anticoagulant therapy. In a pilot study, 10 mg doses of Librium were administered t.i.d. for ten days to ten “normal” volunteers who submitted to routine tests employed in the diagnosis of a suspected hemorrhagic diathesis. Librium had no demonstrable effect on any of the screening procedures. Subsequently, nine patients on long-term warfarin therapy, eight with ischemic heart disease and one with rheumatic heart disease, were kept on the same dosage of Librium for two weeks preceded or followed by a placebo for two weeks. Coagulation tests performed at the outset and after each two-week phase showed no alteration in the degree of anticoagulation achieved, suggesting that the tranquilizer may be safety prescribed in the medical management of such patients.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

The effect of subpressor doses of angiotensin II was studied in five normal subjects and in ten cirrhotic patients with ascites. The normal subjects were kept on normal and low salt diets. The low salt diet caused a diminution in the urinary sodium excretion, accompanied by a decrease in the filtered sodium load. No variation of renal plasma flow was noticed. Subpressor doses of angiotensin caused, under both regimens, a significant decrease in the urinary sodium excretion and renal plasma flow, without any significant change in the filtered sodium load. In the cirrhotic patients subpressor doses of the drug caused a decrease in the urinary sodium excretion, filtered sodium load and renal plasma flow. Angiotensin, administered to these patients in pressor doses, did not decrease urinary sodium excretion significantly, in spite of the fact that it caused a greater depression in the proximal sodium load than that observed with subpressor doses of the drug. The hypothesis is forwarded that if the renal vasculature responsiveness to the drug was smaller than the one corresponding to the other body arterioles, there would be an increase in intrarenal perfusion pressure which would eventually cause natriuresis.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID