ISSN:0002-9629    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Abstract:Thirty patients with diabetes mellitus were compared in terms of carrier rate of four pathogens to a group of matched controls. The diabetics were found to have a significantly increased carrier rate (p< 0.005). When the blood glucose level was used as an indicator of control an increased rate was found in those with the poorest control (p < 0.0005). An increased carriage ofCandida albicansmight be attributed to hypovitaminosis A and its effect on mucous membranes and the skin. Ten percent of diabetics were carrying &bgr;‐hemolytic group A streptococci. In a future study these patients will be checked for persistence of these organisms as well as to see if the strains are of the nephritogenic type. A significantly increased carriage rate in diabetes of coagulase‐positiveStaphylococcus aureuswas found. These findings suggest an additional risk factor in the outpatient diabetic population.

ISSN:0002-9629    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Abstract:Echocardiograms were recorded in six patients with calcification of the mitral annulus. Echocardiographic sweep from the aorta to the left ventricular cavity revealed dense echoes, representing annulus calcification, posterior to the mitral valve. Characteristic calcium deposits in the region of the mitral annulus were detected on the chest roentgenogram of only a single subject. Cardiac fluoroscopy demonstrated calcified mitral annulus in all patients. In one patient, coexisting calcified mitral annulus and proven pericardial effusion were diagnosed echocardiographically. It is concluded that the echocardiogram represants a useful noninvasive technic for the diagnosis of calcified mitral annulus.

ISSN:0002-9629    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Abstract:The ultrastructural findings in a muscle biopsy of a patient with Cushing's disease associated with severe myopathy are described. They included pronounced mitochondrial damage, thickening and deep invaginations of the sarcolemmal basement membrane, and thickening of the basement membrane of the capillaries. In addition, the muscle fibers showed a marked degree of disarray and wide interfibrillar spaces, containing large numbers of vacuoles, which presented degenerated mitochondria. The similarity between these findings and the ultrastructural features of corticosteroid‐induced myopathy is discussed.

ISSN:0002-9629    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Abstract:The clinical and radiological findings of four patients with chronic eosinophilic pneumonia are presented. This brings the total number of cases in the English literature to 27. A comparison of all 27 patients is given. The syndrome can readily be distinguished from other eosinophilic pneumonias. After appropriate evaluation, a therapeutic trial can often be initiated with corticosteroids without the necessity for histologic confirmation of the diagnosis.

ISSN:0002-9629    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Abstract:Two patients are presented who were uremic requiring dialysis despite steady state serum creatinine levels (Cr) of 4.0 and 4.4 mg percent. Their blood urea nitrogen/creatinine (BUN/Cr) ratios of 54 and 44 were shown to be due to excessive creatinine secretion and urea reabsorption. Evaluation of serum creatinine alone may occasionally give misleading information regarding the level of renal function. If clinical evidence of uremia is present while serum creatinine value is relatively low, measurement of glomerular filtration rate (GFR) by Na‐iothalamate125I (OIT) or inulin is essential.

ISSN:0002-9629    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Abstract:Tests to evaluate body iron stores were compared in patients with iron deficiency and the anemia of chronic disease. The serum ferritin assay separated these disorders in 20 of 22 patients. One discrepancy was explained by the concomitant association of both disorders. From this study and review of literature a low serum ferritin level is a good indication for iron therapy. The serum ferritin assay is a clinically useful test in lieu of bone marrow estimation of body iron stores to detect patients with iron deficiency. Total iron binding capacity levels when high‐normal or elevated are sometimes helpful as a screening test in separating iron deficiency from the anemia of chronic disorders. Free erythrocyte protoporphyrin values were elevated in both conditions but were higher in iron deficiency than in the anemia of chronic disorders with considerable overlap of values. Urinary iron excretion with deferoxamine was not helpful in separating these disorders but is a useful test to establish iron overload. An elevated serum ferritin level is usually found with disease of iron overload but serum iron levels, deferoxamine iron excretion tests, and liver biopsy for estimation of iron stores are still beneficial diagnostic aids.

ISSN:0002-9629    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Abstract:The 12‐lead scalar electrocardiogram has been correlated with angiographically determined left ventricular dimensions in 103 consecutive patients in order to determine the reliability of the electrocardiographic diagnosis of left ventricular hypertrophy. Simple and multiple correlations between various parameters of QRS complex voltage and left ventricular mass, volume and wall thickness were poor but statistically significant. Mean voltage of QRS complex parameters was higher in patients with increased left ventricular mass and volume than in those with normal mass and volume, but the sensitivity of individual voltage parameters in identifying increased mass and volume was poor. A negative T wave in lead I or V6was the most sensitive indicator of increased left ventricular mass and volume, but the specificity of this variable was poor. The sensitivity of “high voltage” of the QRS complex was increased (67 percent true positives) when moderate to marked increase in left ventricular mass had occurred, but at the expense of decreased specificity (13 percent false positives). It is concluded that while an increase in left ventricular dimensions tends to be associated with an increase in QRS voltage and a repolarization abnormality, the currently used electrocardiographic criteria for the diagnosis of left ventricular hypertrophy are both insensitive and nonspecific.

ISSN:0002-9629    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Abstract:A randomized trial of carbenicillin plus cephalothin versus carbenicillin plus cefazolin was conducted for the treatment of 334 episodes of presumed or proven gramnegative bacillary infections in neutropenic patients. The total daily dose of cephalothin and cefazolin was 12 g and 4 g, respectively. The total daily dose of carbenicillin in each regimen was 30 g. The response rates among identified infections was 52 percent and 49 percent, respectively. The majority of identified infections were cases of septicemia, pneumonia, and soft tissue infections, and the predominant organisms wereKlebsiellaspp. andPseudomonas æruginosa. The overall response for Klebsiella infections was only 12 percent. Carbenicillin was more effective than the cephalosporins against infections caused by sensitive organisms. The response rate for infections caused by carbenicillin‐sensitive/cephalosporin‐resistant organisms was 70 percent, whereas it was 31 percent for infections caused by carbenicillin‐resistant/cephalosporin‐sensitive organisms (p < .01). Response rates were idependent of the patient's initial neutrophil count but were higher among those patients whose neutrophil count increased during their infection. Toxicity with both of these regimens was minimal and consisted mainly of electrolyte imbalance. The results of this study indicate that, at the doses used, the two cephalosporins are equally effective. However, neither regimen was optimal for neutropenic patients.

ISSN:0002-9629    

出版商:OVID    

年代:1977

数据来源: OVID

摘要:

Abstract:Endocarditis due toListeria monocytogenesis rare with only 13 cases cited in the world's literature. We report an additional case with a review of the previously reported patients. In contrast to other clinical forms of listeriosis, endocarditis does not tend to occur in patients with severe underlying disorders or those on immunosuppressive regimens. Listeric endocarditis has a predilection for left‐sided cardiac involvement (100 percent), and systemic embolization is a major clinical feature (58 percent). Prognosis of listeric endocarditis is unfavorable and the mortality rate (43 percent) exceeds that for bacterial endocarditis with more common pathogens (23 percent). Antibiotic sensitivity data suggest that ampicillin or penicillin may be the chemotherapeutic agents of choice.

ISSN:0002-9629    

出版商:OVID    

年代:1977

数据来源: OVID