ISSN:0002-9629    

出版商:OVID    

年代:2000

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:2000

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:2000

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:2000

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:2000

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

BackgroundInhibition of nitric o-ide (NO) synthase by l-arginine analogs is associated with elevation of blood pressure in rats. Because endothelium-dependent vasomotion in different vascular beds is not homogenous, the aim of this study was to characterize and compare regional hemodynamic responses in carotid, femoral, and renal vascular beds after chronic NO inhibition in spontaneously hypertensive rats. The possible role of circulating endothelin and renin angiotensin systems in mediating the effects of chronic NO inhibition was also studied.MethodsSystemic and regional hemodynamics, left ventricular mass, plasma renin activity, and plasma endothelin-1 were determined in control and N&ohgr;-nitro-l-arginine methyl ester (L-NAME)-treated (10 mg/kg/day, 4 weeks) spontaneously hypertensive rats.Resultsl-NAME treatment increased arterial pressure and total peripheral and regional vascular resistance and decreased cardiac output, stroke volume, and regional blood flow. An increase in blood flow ratio and a decrease in vascular resistance ratio between carotid and renal as well as femoral and renal vascular beds in rats treated with L-NAME was found. Blood flow and vascular resistance ratios between femoral and carotid vascular beds remained unchanged. l-NAME increased plasma renin activity and left ventricular weight/body weight ratio, whereas plasma endothelin-1 was not modified.ConclusionsThe results of this study showed that the renal circulation seemed to be more sensitive to the effects of chronic NO inhibition than carotid and femoral vascular beds. Simultaneous activation of the renin angiotensin system may further potentiate cardiovascular effects of chronic NO inhibition. No evidence that circulating endothelin-1 plays a role in this model of hypertension was found.

ISSN:0002-9629    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

BackgroundPrevious articles have reported the appearance of leukopenia after the administration of high-dose intravenous &ggr;-globulins.MethodsA simple slide test was used to reveal the state of leukocyte aggregation (LA) in the peripheral blood as well as the absolute number of leukocytes in the slides.ResultsA significant (P< 0.00001) increment was noted in the state of LA, from 9 ± 6% before to 25 ± 11% after &ggr;-globulin administration. This was accompanied by a significant (P< 0.0004) reduction in the number of white blood cells in the peripheral blood (from 8433 ± 3905 to 6550 ± 3252 cells/mm3) but no significant change in the absolute number of the cells as determined by the leukocyte count per high power field in the peripheral slides.ConclusionsWe raise the possibility that the leukopenia reported in some patients after the intravenous administration of high dose &ggr;-globulin is e-plained in part by the agglutination effect of the drug.

ISSN:0002-9629    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

BackgroundThe serum level of soluble tumor necrosis factor receptor II (sTNF-R75) has been recently found to correlate with the activity and/or severity of several different infectious and inflammatory diseases. These results have led us to presume that the serum sTNF-R75 level reflects the active immune activity of all causes and may correlate well with nonspecific infectious and inflammatory markers such as peripheral leukocyte counts and serum C-reactive protein level.MethodsIn total, 110 apparently healthy adults, 55 men and 55 women, were enrolled in the study. Serum levels of sTNF-R75, C-reactive protein, globulin, alkaline phosphatase, lactate dehydrogenase, creatinine, urea nitrogen, and counts of neutrophils, lymphocytes, monocytes, eosinophils, and basophils were checked. The relationships between the serum sTNF-R75 level and other parameters were analyzed using the SAS statistical program.ResultsBy various statistical methods, the serum sTNF-R75 level showed consistently significant positive links with peripheral monocyte count, serum C-reactive protein level, and two parameters of renal clearance function (serum urea nitrogen and creatinine levels). Serum levels of alkaline phosphatase and lactate dehydrogenase had significant positive links with the serum sTNF-R75 level by multivariate regression analysis. There was no significant link between the serum sTNF-R75 level and counts of neutrophils, lymphocytes, eosinophils, or basophils.ConclusionsOur results, together with those of recent reports showing positive correlations between the serum sTNF-R75 level and activities/severities of different infectious and inflammatory diseases, and also that TNF-&agr; is principally produced by monocytes and macrophages, suggest that the serum sTNF-R75 level is very probably an inde- of overall monocyte-related infectious and inflammatory activities.

ISSN:0002-9629    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

Proteinuria may be associated with a renal or systemic disease, or it may be isolated. The latter occurs in asymptomatic patients without evidence of any disease or abnormality of the urine sediment. Isolated proteinuria may be subdivided into two broad groups: (1) benign forms, with a favorable-to-excellent prognosis and (2) persistent forms, some of which have a worrisome prognosis. Functional proteinuria may occur in disorders with altered renal hemodynamics, usually resolves, and is not associated with progressive renal disease. Idiopathic transient proteinuria is typically discovered on routine screening and usually disappears on subsequent testing. In idiopathic intermittent proteinuria, a significant number (50%) of urine samples exhibit abnormal rates of protein excretion. Although structural abnormalities may be observed on renal biopsy, progressive renal insufficiency is unusual. In orthostatic proteinuria, the rate of protein excretion completely normalizes in the recumbent position. Long-term studies show this to be a benign condition. In persistent isolated proteinuria, at least 80% of random urine samples exhibit abnormal protein excretion. This represents a heterogeneous group, but a significant proportion of these patients have prominent renal pathologic findings and progress to serious renal disease. Proteinuria with significant renal disease may be non-nephrotic or nephrotic range. The former does not exclude glomerular disease, but tubulointerstitial or vascular disorders are also likely when proteinuria is less than 2 g/24 hours. Patients with nephrotic-range proteinuria generally have a glomerular disorder. Distinction between benign and more ominous forms of proteinuria requires careful evaluation.

ISSN:0002-9629    

出版商:OVID    

年代:2000

数据来源: OVID