ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Abstract:Serial urine cultures were evaluated in 82 patients with noninfectious parenchymal renal disease confirmed by renal biopsy in order to assess the incidence and morbidity of bacteriuria. The mean period of observation was 26 months (6 to 73 months), and mean number of cultures was 17 per patient (2 to 80). Primary diagnoses were glomerulonephritis, arteriolar nephrosclerosis, diabetic glomerulosclerosis and miscellaneous. Bacteriuria was found in 15 patients (18%). Six males (13%) and nine females (24%) comprised this group. Only two (2.4%) acquired bacteriuria for the first time during the study period. All of the males had urinary tract obstruction or immunological deficiency, and some of the females appeared to have only bladder infections. Morbidity associated with bacteriuria was low in a setting in which relief of obstruction and appropriate antimicrobial treatment was given to these patients. A deleterious effect of bacteriuria upon the underlying renal disease could not be documented in any patient. Bacteriuria should not be attributed to the underlying renal disease until appropriate urologic evaluation of the patient has been performed.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Abstract:Lymphocyte circulation was studied in three hematologically normal humans and one patient with chronic lymphocytic leukemia, utilizing autologous blood lymphocytes which had been labeled with Na251CrO4. The final preparation consisted of at least 95% lymphocytes, and at least 95% of these cells were viable. During the first 30 minutes after infusion there was a rapid fall in blood activity which was associated with a rapid increase in splenic uptake in all four patients. Considerable radioactivity was noted over the liver throughout the study, but rapid changes similar to those occurring over the spleen were not noted during the initial 30 minutes after infusion. Little uptake was noted at any time over the bone marrow or lungs. After the first day there was a gradual fall in blood activity for approximately one week, and then the rate of decline was even less rapid. A somewhat similar disappearance curve was obtained for splenic activity. Uptake of label was comparatively greater over the liver after infusion of dead cells.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Abstract:One hundred thirty patients treated with anticancer drug therapy were analyzed. Alkylating agent toxicity was predominantly hematopoietic, antimetabolites and natural products produced equal incidence of hematopoietic and gastrointestinal toxicity. A minor degree of drug toxicity was necessary for response, but progressive toxicity did not increase responders. Responses were accompanied by prolongation of survival. Up to four previous courses of drugs did not prevent subsequent achievement of responses, nor increase drug‐induced toxicity. The latter findings may be due to natural selection of patients with slow growing tumors for repeated trials. Chemotherapy need not be pushed to severe toxicity to obtain responses. There was no evidence that chemotherapy was detrimental to patient survival.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Abstract:The hemodynamic effects of lidocaine given as bolus injections and by infusion were studied in 19 anesthetized dogs before and after acute myocardial infarction produced by a two stage ligation of coronary arteries. The infarcted tissue represented an average of 36.2% of the weight of the left ventricle. Lidocaine infusion at a rate of 200 &mgr;g/kg/min produced significant elevations of left ventricular dp/dt, cardiac output, and systolic left ventricular and aortic pressures before experimental myocardial infarction, with significant elevations in cardiac output only, following the coronary artery ligation. Prior to myocardial infarction bolus injections of 5 mg/kg lidocaine resulted in decreases in left ventricular systolic and aortic pressures, left ventricular dp/dt, cardiac output, heart rate and systemic vascular resistance lasting approximately five minutes. After coronary artery ligation the same dose of lidocaine produced more prominent circulatory changes of longer duration, including elevation of left ventricular diastolic and left atrial pressures. It is concluded that large doses of lidocaine given as a single injection can produce significant circulatory depression in a heart compromised by myocardial infarction.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Abstract:Florisil has been utilized to separate protein‐bound and unbound tracer testosterone‐1,2‐3H in dilute serum. Testosterone binding affinity (TBA) has the following order; pregnant females and estrogen treated females> menstruating females> post‐menopausal females; hyperthyroid patients> menstruating females> adult males; pre‐pubertal males> adult males.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Abstract:Patients with hyperlipoproteinemia have elevated serum vitamin E levels. Seven patients with hypercholesterolemia and eight other patients with hypertriglyceridemia achieved lowering of serum lipids when treated with clofibrate and SU‐13437, a chemically similar drug. Serum vitamin E levels decreased with the hypolipidemic therapy and returned upward when therapy was discontinued.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID