ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Using an easily performed and reproducible test, patients with tight mitral stenosis showed a statistically significant decrease in vital capacity immediately after two step exercise. A similar decrease was also found in patients with left ventricular failure. These findings correlated well with increased pulmonary capillary wedge pressure and/or left ventricular diastolic pressure induced by leg exercise. The availability and simplicity of the immediate post exercise vital capacity recommend it as a practical clinical test to assess disease affecting the left side of the heart.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Cardiac patients and normal subjects were studied during treadmill exercise which produced a voluntary cessation of exercise within three minutes. Breaking point oxygen uptake was low in most of the cardiac patients. Breaking point heart rate was below 160 in approximately half of the cardiac patients, but rarely in normals. Those patients with breaking point heart rates below 130 had very advanced disease. Breaking point cardiac output and stroke volume were low in the cardiac patients, with a wide variability in arterio-venous oxygen difference. The rise of cardiac output was delayed in three of eight cardiac patients. Breaking point lactates were lower in the cardiac patients as compared to the normals; in both groups the lactatc values were proportional to exercise time. Total intrapleural (esophageal) pressure change during the breathing cycle was high in those cardiac patients who stopped because of dyspnea. We conclude that the exercise breaking point in cardiac patients is produced by an interaction of cardiac, pulmonary, and peripheral factors, any one of which may dominate in a particular patient.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

It has been suggested by others that significant depression of thyroid function may occur with diazepam. Twenty-four cuthyroid normal adults were studied in a double-blind crossover investigation using diazepam and placebo for 12 to 18 weeks. Serial thyroid function studies were done. Very small but statistically significant changes in PBI, thyroxine and Taresin uptake were observed and shown to be due to individual, day to day variability. No changes were found in serial131I thyroidal uptakes. We have been unable to substantiate previous observations which indicate thyroid function is altered by diazepam.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Cephalothin and cephaloridine are absorbed poorly from the gastrointestinal tract and are effective only by the parenteral route. Cephaloglycin is absorbed better when given orally but not as well as cephalexin. Comparison was made in this study of the effect of the four drugs in the therapy of rhesus monkeys infected, intravenously, with a Group A hemolytic streptococcus at a dose level lethal to untreated controls. With this model, cephaloridine prevented death in monkeys receiving only 12.5 mg/kg/day. Cephalexin given intragastrically was as effective as cephalothin given intramuscularly at dose levels of 25 or 50 mg/kg/day. After the former dose two of four survived in each group, while after 50 mg/kg seven of eight and six of eight receiving cephalothin and cephalexin, respectively, survived. Higher doses of cephaloglycin were required and three of four survived after 100 mg/kg doses. The availability of an effective orally-absorbed cephalosporin would be desirable. These data suggest that cephalexin, in particular, shows promise in this area.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Carbenicillin was administered during 56 episodes of gram-negative bacilli infection occuring in patients with acute leukemia and metastatic cancer. The response rate was 91% in 23 episodes ofPscudomonassp. infections, and 58% in 12 episodes ofE. coliinfections. Carbenicillin was ineffective against infections caused bySerratiasp. andKlebsiellasp. The majority of patients who responded become afebrile within 48 hours. Toxicity was limited to nausea, vomiting, hypersensitivity reactions, and transient elevations in scrum transaminases.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Availability of a relatively specific antiserum to glucagon has made possible studies of alpha cell function in man. In healthy volunteers fasting plasma glucagon averaged 13G μμg/ml (SEM ± 20); in genetic diabetics, despite their hyperglycemia, glucagon averaged 150 μμg/ml (± 26). In all normal subjects and genetic diabetics arginine infusion elicited significant increases in plasma glucagon within five minutes, with a peak at 40 minutes. The mean maximal increment of glucagon was 270 μμg/ml (± 30) in normals and 340 μμg/ml (± 60) in diabetics. In a patient with severe pancreatitis, however, glucagon was zero throughout the entire experiment. In normals the mean maximal glucose rise during arginine infusion was 16 mg7, while in genetic diabetics it was 48 mg7. It is concluded, first, that arginine induces hyperglucagonemia in normals and in presumably genetic diabetics, and that in diabetics hyperglucagoncmia, unaccompanied by proportional hyperinsulinemia, may contribute to the greater hyperglycemia; second, in genetic diabetes byperglycemia fails to reduce either the fasting glucagon concentration or the glucagon response to arginine, suggesting hypo-suppressibility of the α cell; and third, in juvenile diabetes, the α cells' capacity to synthesize hormone remains intact long after that of the cell is completely lost, suggesting an isolated α cell lesion, rather than diffuse involvement of the islet, as in the patient with severe pancreatitis.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID