ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

Abstract: This study was intended to determine whether or not the effect of exercise on pulmonary diffusing capacity for carbon monoxide (Dlco) is altered by limiting blood flow from exercising limbs. Breathholding Dlcowas determined in 12 normal subjects, seated and supine, at rest and during exercise, with and without venous occluding tourniquets on arms and thighs, and after release of tourniquets. The increase in Dlcoafter three minutes of exercise was not significantly different with and without tourniquets, seated and supine. The initial rise in Dlco, during the first ten seconds of exercise, was significantly decreased by venous occluding tourniquets. This study shows that partially occluding the flow of blood (and humoral substances) from exercising muscles does not alter the overall increase in Dlcoproduced by exercise, but does decrease the rise in Dlcoduring the first ten seconds of exercise. It supports previous observations that the initial increase (first ten seconds of exercise) and the later increase are caused by different mechanisms.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

Abstract: A study was carried out on paired serum specimens from 150 children with gram-negative infections regarding the immune response to O antigen and the common antigen (CA) of enteric bacteria. Included in the series were 50 patients with shigellosis, 50 subjects with salmonella enteritis, and 50 patients with infection of the urinary tract due to gram-negative microorganisms. CA antibodies in titers of 1:160 or higher were present in 56% of subjects with shigellosis and only 24 or 18% of patients with salmonellosis or urinary tract infection. Significant increases or decreases in the titers of antibodies in paired serum specimens were also seen more frequently in patients with shigellosis than in the others. In all patients with salmonellosis and urinary tract infection the homologous antibodies against the respective O antigens were higher than those against CA; in contrast, nine of 50 patients with shigellosis had higher CA than O antibody titers. It is suggested that the site of infection may be a significant determinant of the CA immune response of patients with gram-negative infection.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

Abstract: Antibacterial activities of serum and urine following oral administration of single doses of the antibiotic clinimycin were measured by two different assay methods. In one crossover study in 12 adult males, it was found that food, including coffee and milk, had little, if any, effect on the absorption efficiency of 250 mg doses of the antibiotic. Administration of the antibiotic one hour after food and with food caused a shifting of the average serum activity curve on the time axis compared with results obtained when the antibiotic was administered under fasting conditions or one hour before food. In a second crossover study in 12 adult males, it was found that both the rate and efficiency of absorption of the antibiotic, as judged by serum and urine activities, were essentially the same following administration of 150 mg doses in capsule and tablet forms. The antibiotic is absorbed extremely rapidly in man following oral administration, since serum activities observed 24 minutes post-administration were very close to the peak activity observed at 45 minutes. The half-life of clinimycin, estimated from serum activities obtained with the extraction assay, averaged 2.38 hours with a range of 1.50 to 3.54 hours.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

Abstract: Sera obtained during acute viral hepatitis agglutinate rhesus RBC significantly more often than normal sera. The agglutinins resemble those occasionally found in normal sera in their behavior on absorption with guinea pig kidney, beef BBC and sheep BBC. Tests using BDE-treated BBC suggest that the antigen does not contain sialic acid. Absorption tests with rhesus and sheep BBC show that the agglutinins are, in fact, specifically directed against sheep BBC with cross-reactivity to rhesus BBC. In this respect, they resemble serum sickness sera, which also agglutinate rhesus BBC. In contrast to their increased frequency in acute cases, these agglutinins were rarely found in convalescent cases, where the frequency of positive tests was significantly less than that of normal persons. A high frequency of positive tests was also found in infectious mononucleosis and in alcoholic liver damage, but not in measles or mumps. This suggests that rhesus agglutinins are not a nonspecific effect of viral infection but may be the result of hepatic damage.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

Abstract: Hyperuricemia is often associated with thrombosis, particularly of the coronary arteries. Platelet aggregation is one of the earliest stages of thrombosis and is probably mediated by adenosine diphosphate (ADF) irrespective of the stimulus. However, aggregation by ADP is reversible and this reversibility is attributed to the degradation of ADP in the blood. Uric acid is a metabolite of the adenine nucleotides, including ADP, and blood levels may affect the degradation of ADP in the blood. Rats given uric acid intravenously one minute prior to injection of ADP had a 50% rise in the mean serum uric acid level (p < 0.05) and a significant increase in the incidence of pulmonary platelet thrombi (p < 0.001) when compared to control animals given buffered saline and ADP. Rats given warfarin sodium, 2 mg/kg, intraperitoneally for two days had a prothrombin time > 300 sec, a lowered mean serum uric acid level (p < 0.01) and a reduction in die incidence of ADP-induced pulmonary platelet thrombi compared to saline treated controls (p < 0.01). Warfarin treated rats given uric acid prior to injection of ADP had a prothrombin time > 300 sec, and no reduction in the mean serum uric acid level or incidence of thrombosis when compared to saline treated controls. It is hypothesized that alterations in blood levels of uric acid influence ADP-induced platelet thrombosis by an effect on the rate of degradation of ADP in the blood.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

Abstract: An intravenous preparation of allopurinol has been developed and tested in patients with hyperuricemia secondary to neoplastic disease. The preparation, sodium allopurinol, is readily soluble, stable, easily administered, rapidly effective, and nontoxic. The recommended dosage is 350 to 700 milligrams per square meter body surface area, given as a 24 hour infusion. Toxicity studies in monkeys indicated that prolonged administration of high doses of intravenous allopurinol can lead to hepatic damage, and to impairment of renal function due to precipitation in the renal collecting tubules of oxypurinol, the relatively insoluble metabolic end-product of allopurinol. However, patients treated with doses up to 720 milligrams per square meter body surface area per 24 hours for four days exhibited no evidence of drug toxicity.

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1968

数据来源: OVID