ISSN:0002-9629    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

The breathing patterns after voluntary hyperventilation were determined in 14 healthy young subjects under four different conditions: (1) normoxia, (2) hyperoxia, (3) hypoxia, and (4) sudden administration of oxygen against a background of hypoxia to evaluate the effect of hypoxia on the pattern of the posthyperventilation breathing. Under hypoxia the ventilation in the immediate posthyperventilation period was depressed although no decreased ventilation was observed under hyperoxia or normoxia in this period. Sudden administration of oxygen depressed further the decreased ventilation in the posthyperventilation period.

ISSN:0002-9629    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

A comparison of ventilatory tests and the response to carbon dioxide rebreathing was made in healthy smokers, nonsmokers, and in subjects with bronchitis. The response to carbon dioxide (CO2) rebreathing was the same in the healthy population but diminished in the bronchitic group. Effects of smoking on maximal expiratory flow rates did not correlate with the results of carbon dioxide rebreathing. A consistent pattern of relationship of ventilation response to carbon dioxide and age of the subject was apparent.

ISSN:0002-9629    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

Studies of the hormone-receptor interaction have introduced a new chapter in endocrine and metabolic disorders. Receptor (R) dysfunction in human diseases, due either to an alteration in the number or affinity of the R, or to antibodies against the R, is reviewed and classified in the first part of this paper. Disorders where hormone resistance has been implicated, but where R studies are still unavailable are also presented.

ISSN:0002-9629    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

Hypothyroid patients with total or near-total thyroidectomy were found to have detectable immunoreactive calcitonin in the serum and urine. These findings suggest that human calcitonin may be secreted by extrathyroidal tissues.

ISSN:0002-9629    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

The adrenal responses to insulin-induced hypoglycemia and the rapid adrenocorticotropic hormone (ACTH) stimulation test were compared in 24 healthy volunteers, 18 of whom also underwent a rapid oral metyrapone test. The cortisol levels after hypoglycemia (18.0–30.0 μg/100 ml) were similar to and directly related to the levels after ACTH (21.0–31.0 μg/100 ml). The levels after both stimuli were independent of age, sex, height, and weight. The 11-deoxycortisol response to the metyrapone test was less than the cortisol response to hypoglycemia and metyrapone administration was associated with more unpleasant side effects. In a group of 69 control subjects, the post-ACTH cortisol levels were 15.0 to 80.0 μg/100 ml while in seven patients with Addison's disease they were <1–4.5 μg/100 ml. In 44 control subjects, the posthypoglycemia cortisol levels were 18.0 to 30.0 μg/100 ml compared with <1.0–9.0 /μg/100 ml in 22 patients with hypopituitarism. The absolute poststimulation cortisol levels provided better separation of control subjects from patients with adrenal or pituitary insufficiency than either the increment in cortisol levels or the 11-deoxycortisol response to metyrapone.

ISSN:0002-9629    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

Concern over the increased occurrence ofPseudomonas aeruginosaresistant to gentamicin colonizing and/or causing disease in patients prompted our review of the years 1974 and 1975 for allP aeruginosaisolates, both gentamicinresistant and gentamicin-sensitive. In this period, 39 patients had gentamicin-resistantP aeruginosarecovered from clinical specimens while 683 patients had gentamicin-sensitive strains. Compared to both matched and/or randomly selected controls with gentamicinsensitive infections, patients with gentamicinresistant infections had a higher incidence of (1) prior antibiotic therapy (p < 0.01), (2) prior therapy with gentamicin (p < 0.005), and (3) exposure to multiple antibiotics.

ISSN:0002-9629    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

Influence of imidazole carboxamide (DTIC, NSC-45388)on some platelet functions, plasma coagulation, and fibrinolysisin vitrowas investigated, using different concentrations of the drug (80 and 160 μg/ml). The lower concentration, which corresponds to that obtained in plasma after administration of therapeutic doses in man, did not significantly influence any of the important platelet functions. It is concluded that after current dosage of the drug, bleeding disorders caused by impairment of platelet functions are improbable. However, following the higher concentration of DTIC, a significant inhibition of the increase in light transmission of platelet-rich plasma provoked by standardized freezing and thawing procedure, was demonstrated. Furthermore, the same dose of the drug caused partial retardation of the retraction of reptilase clots. The authors assume that DTIC has a “stabilizing effect” on the cell membrane, particularly in higher concentrations.

ISSN:0002-9629    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

The clinical, electrocardiographs, angiographic, and hemodynamic features of seven patients with isolated, severe (>75% of diameter) narrowing of a diagonal branch of the left anterior descending artery are presented. The incidence of this entity was 0.5% among patients with arteriosclerotic heart disease undergoing coronary angiography. Angina was severe in two patients, moderate in four, and mild in one. One patient had unstable angina. Stress tests were abnormal in two of three patients. Six patients had normal left ventricular angiograms, and one had a mildly decreased ejection fraction. All patients surviveda meanfollow-up of 18 months (range 6 to 32). No patient suffered a myocardial infarction. Five became asymptomatic on medical therapy; one patient with mild and another with moderate angina were unimproved. This rare anatomic subset of patients with coronary artery disease has a favorable short-term prognosis.

ISSN:0002-9629    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

Acute cardiorespiratory failure occurred in a patient with advanced bullous emphysema following perfusion photoscintigraphy with radiolabeled macroaggregated albumin. Complications of perfusion photoscintigraphy are rare. However, in patients with advanced pulmonary vascular disease, special precautions may decrease the minimal hazard associated with perfusion photoscintigraphy.

ISSN:0002-9629    

出版商:OVID    

年代:1978

数据来源: OVID