ISSN:0002-9629    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Minocycline was 60 per cent effective in the elimination of group C meningococci from healthy carriers among naval recruits without selection of resistant strains Rifampin was 89 per cent effective against the same group of meningococci with the selection of rifampin-resistant strains. Rifampin-resistant strains did not spread to new susceptibles and only a few persisted in follow-ups of carriers. Selective treatment of group C carriers with minocycline and rifampin temporarily reduced the carrier rate in the treated men. Although a high percentage of group C carriers were cured by treatment with minocycline or rifampin, group C meningococci ultimately infected the same proportion of men as before treatment. Group C reacquisitions and spread of group C organisms to non-carriers rapidly overcame the curative effect of minocycline. Rifampin, however, was somewhat more successful in allowing non-group C to predominate in this population.

ISSN:0002-9629    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Fulminant pneumococcal meningitis was the presenting manifestation of a chromophobe adenoma of the pituitary in an asymptomatic healthy young man. Routine skull radiography revealing an enlarged destroyed sella turcica identified the primary pathology. Erosion into the sphenoid sinus, presumably by opening up a portal of entry for pyogenic bacteria into the cranial cavity, resulted in one of the rarest modes of presentation of pituitary neoplasm. The importance of corticosteroids in therapy is discussed.

ISSN:0002-9629    

出版商:OVID    

年代:1972

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1972

数据来源: OVID

摘要:

Eighteen medium-sized mongrel dogs were used to study experimental enterococcal endocarditis. Aortic valve Injury was accomplished by needle punctures through a catheter in the left carotid artery. Thirteen dogs survived the procedure and one week later received a suspension of 107enterococci intravenously. In 10 dogs a sustained bacteremia of 102organisms per milliliter of blood or greater occurred within one week and rose to 103in all but one animal shortly before death or sacrifice. Necropsy was performed in the dogs from 3 to 103 days after inoculation. Vegetative endocarditis involving both aortic and mitral valves occurred in 9 of 10 canine subjects. Bacterial counts on affected valves ranged from 107to 109per gram of tissue. Thromboembolic and hemorrhagic lesions were noted in the kidneys, myocardium, spleen, and lungs. The simplicity of this technique should prove this a useful model for therapeutic and patholophysiologic studies.

ISSN:0002-9629    

出版商:OVID    

年代:1972

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1972

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1972

数据来源: OVID