ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

Megestrol acetate given orally has been assessed in its effect on sicklingin vitro.Per cent sickling rates were reduced by the drug compared to placebo. The results indicate the need for further assessing the clinical advantage of oral progestins in patients with sickle cell disease which may also be relevant to their use as contraceptives.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

Two screening tests by means of subjective responses of patients with active rheumatoid arthritis are described. In both, daily telephone interviews were used to gather data concerning drug preference or a comfort index. These studies adhered to the requirements for meaningful evaluations of subjective data. In the first study, one drug—aspirin or fenoprofen (dl-2-[3-phenoxyphenyl] propionic acid)-and placebo were compared over a four-day interval. The interpretations of the results of this study were supported by those of the second study in which each medication was given continuously for seven days. The patients preferred aspirin and fenoprofen to placebo, and reported placebo to provide less comfort than either of the other medications.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

The pulmonary diffusing capacity (DL) has been exhaustively studied in various body positions. Data are available for standing, seated, 60° head-up tilt, and supine positions. Observations in the completely inverted position (head-down), however, are lacking. The purpose of this study was to evaluate DLin this position and to compare it with DLin other positions. Breath-holding DLCO was determined in 22 normal male and female subjects in standing, seated, 45° head-down tilt, supine, and inverted positions. Mean DLCO in the inverted position was significantly higher than in the standing position (p<0.001) and seated position (p<0.001 for male and p<0.05 for female). Mean DLin the inverted position was also significantly higher (p<0.05) than the 45° head-down tilt position (Fowler's) in female subjects, but not significantly different in male subjects. This study suggests that the inverted (head-down) position has the same effect as the supine position on pulmonary diffusing capacity and supports the view that its effect is due to the gravitational adjustments to circulation and ventilation acting on the lungs.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

Unequal distribution of ventilation, perfusion, and ventilation-perfusion ratios is recognized as the primary alteration of physiology in patients with emphysema and/or chronic bronchitis. A study was performed to see how the interaction of these inequalities is reflected in the results of more commonly used tests of pulmonary function. Sixteen patients with emphysema and chronic bronchitis combined were studied by a single breath test monitored by a respiratory mass spectrometer. Increased unevenness of ventilation, found in all patients, correlated negatively with arterial oxygen saturation and positively with arterial carbon dioxide tension to a significant degree (p<0.05). The early and predominant role of unequal ventilation in chronic bronchitis with emphysema and the usefulness of the single breath method of assessment were substantiated. Inequalities of perfusion correlated to a significantly positive degree (p<0.01) with unevenness of ventilation. This finding is consistent with a widening of differences in perfusion as a result of the increasing unevenness of ventilation. Negative correlation of arterial oxygen saturation with perfusion inequalities (p<0.05) would indicate that noncompensatory vascular changes predominate. However, a relatively low mean value for ventilation-perfusion ratio inequalities suggests a tendency for vascular alteration to compensate for unevenness of ventilation.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

A patient with Wegener's granulomatosis with nasal, cutaneous and pulmonary granulomas developed rapidly progressive renal failure which progressed despite one week's therapy with prednisone and three days' therapy with prednisone and azathioprine. In view of the presence of material with the tinctorial characteristics of fibrin in the renal biopsy and of elevated levels of fibrin split products in the serum, a prolonged infusion of heparin was administered which resulted in a rapid remission of her renal failure and a progressive improvement in renal function over a ten-week period. The remission has been maintained for the 21 months since heparin was stopped, azathioprine and low dosage prednisone being administered during this time.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

Circulating anticoagulants directed against factor V are thought to be rare and only five well-documented cases are recorded in the literature. A sixth case, differing in several respects from the previously published cases, is reported here in a 44-year-old woman in whom multiple episodes of life-threatening hemorrhage occurred, sometimes into unusual sites, such as the pleural space. Active pulmonary tuberculosis was present at the time of onset of the acquired bleeding disorder. The circulating inhibitor had the physicochemical characteristics of an IgG immunoglobulin. The presence of the inhibitor was not immediately apparent on mixing the patient's plasma and normal plasma, but required a period of incubation. The circulating anticoagulant has been persistently present over a 23-month period of observation despite therapy with prednisone and azathioprine. While no effect on the prothrombin time or factor V concentration was evident during steroid therapy, withdrawal of prednisone was repeatedly associated with recurrent bleeding.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID

摘要:

Severe narrowing, consistent with spasm, producing nearly total occlusion of a minimally diseased segment of the right coronary artery was demonstrated by selective coronary arteriography in a patient with Prinzmetal's variant angina. ST segment elevation occurred in the inferior leads with reciprocal ST depression in the lateral leads during periods of chest pain often precipitated by emotional upset. Similar nocturnal changes were associated with rapid eye movement (REM) sleep from which the patient would sometimes awaken with chest pain. Treatment with propranolol resulted in greater intensity and duration of the chest pain; sublingual isosorbide dinitrate completely abolished the chest pain. The response to treatment was consistent with the possibility that excessive response of the mildly diseased arterial segment to catecholemines may have caused the localized coronary artery spasm.

ISSN:0002-9629    

出版商:OVID    

年代:1973

数据来源: OVID