摘要:

Despite the occurrence of serious side effects, the use of cyclosporin A after organ transplantation has increased because of its ability to effectively suppress allograft rejection. Its use in the treatment of ophthalmic disease has also recently increased. Central nervous system toxicity due to cyclosporin A is a significant but apparently clinically reversible side effect. A liver transplant patient in whom cortical blindness from profound neurotoxicity was the initial presentation is described. Neurologic abnormalities, including cortical blindness, resolved completely after discontinuation of cyclosporin A. However, pathologic studies performed 8.5 months after the initial transplant revealed residual central nervous system demyelination.

ISSN:0272-846X    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

Three youths with occipital seizures and intermittent visual loss are presented. All three had occipital epileptiform discharges. Visual loss occurred during seizures and improved with anticonvulsant medication. In the absence of an underlying structural lesion of the occipital lobe, occipital seizures in children often respond to antiepileptic medication and may spontaneously resolve. As occipital seizures are often associated with headaches and sometimes with vomiting, differentiating them from basilar migraine may be difficult. The possibility of ongoing seizure activity should be considered in a patient who presents with acute visual loss without an obvious cause.

ISSN:0272-846X    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

This study gives some illustrative case reports of the difficulties in the diagnosis of Leber's hereditary optic neuroretinopathy. It underlies the importance of careful family history and search for peripapillary microangiopathy in the maternal relatives of patients suspected to suffer from Leber's disease. The article casts doubt on the existence of so-called sporadic Leber's disease.

ISSN:0272-846X    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

Amiodarone has been implicated in the pathogenesis of optic neuropathy in several cases. However, that relationship is unclear, as subjects placed on amiodarone represent a high-risk group for various vasoocclusive accidents. In order to investigate the effect of amiodarone on the optic nerve, we examined histopathologically sections of the retrobulbar optic nerve obtained from an asymptomatic subject taking amiodarone. Lamellar inclusions were selectively found in the large axons. Amiodarone may have a chronic neurotoxic effect on the optic nerve via a drug-induced lipidosis. This neurotoxicity may be related to some of the acute forms of optic neuropathy described in the literature.

ISSN:0272-846X    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

Anterior ischemic optic neuropathy (AION) is primarily a disease of middle and late life. When it affects the young patient, AION is often due to a specific underlying disease process predisposing to vasculopathy. Reported here are two patients with AION in whom no evidence of associated disease was found. The tendency for recurrent attacks of disc ischemia distinguishes this clinical entity from the more common idiopathic form of AION of older individuals. Hypotheses regarding possible etiology are discussed.

ISSN:0272-846X    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0272-846X    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

The onset of the Melkersson-Rosenthal syndrome, manifested by bifacial paralysis and severe edema of the upper lip in a 25-year-old man, was followed shortly by signs of secondary syphilis.

ISSN:0272-846X    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0272-846X    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

A 51-year-old woman with Sneddon's disease presented with transient right hemifield loss of vision and transient right-sided weakness. Over the preceding decade she had experienced a slow decline in mental function. She also had hypertension, migraine, and a mixed seizure disorder. She had skin changes typical for generalized livedo reticularis but she did not have Raynaud's phenomenon or winter ulcerations. Her disease was not understood until the stroke-related symptoms were associated with the skin abnormalities. We review the neuro-ophthalmic manifestations of Sneddon's disease and add data from our case to the growing body of fact that suggests that Sneddon's disease may be an immunologically mediated vasculopathy.

ISSN:0272-846X    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

Trauma-induced superior oblique palsy usually results from contusion or avulsion of the trochlear nerve or from decompensation of a congenital trochlear nerve palsy. Severe craniocerebral trauma is often associated with the former mechanism, whereas more minor closed-head injuries can decompensate a congenital phoria. We report a patient who developed an isolated trochlear nerve palsy following minor head trauma. Investigation revealed an unsuspected tentorial vascular malformation that was compressing the trochlear nerve in its subarachnoid course. In the absence of other features (e.g., documentation of old head tilt, large vertical fusion amplitudes) that support decompensation of a congenital phoria, compressive lesions should be sought in cases of fourth cranial nerve palsies that follow minor head trauma.

ISSN:0272-846X    

出版商:OVID    

年代:1988

数据来源: OVID