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| 1. |
A comparative Study on the Influence of Prostaglandin E1, Oxytocin and Ergometrin on the Pregnant Human Uterus |
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Acta Obstetricia et Gynecologica Scandinavica,
Volume 49,
Issue S5,
1970,
Page 1-7
U. Roth‐Brandel,
M. Bygdeman,
N. Wiqvist,
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摘要:
The influence of prostaglandin E1(PGE1), oxytocin and methyl ergometrin maleate (Mether‐gin®) on the contractility of the pregnant human uterus was compared in in vivo experiments on 8 early pregnant and 14 midpregnant women. The substances were administered intravenously in separate injections. With the doses used PGE1and oxytocin caused a marked elevation of tone whereas Methergin® had a less significant effect. The duration of the elevation of tone after PGE1was approximately three times longer than that after oxytocin but considerably shorter than after Methergin®. The motility pattern following Methergin® was characterized by small irregular contractions which differed completely from that after PGE1and oxytocin. The pharmacological effect of PGE1on the midpregnant uterus suggests that this substance might reduce blood loss and shorten the period of time for placental separation during the third stage of labour. However, this assumption could not be confirmed as judged from a small clinical pilot study carried out on 188
ISSN:0001-6349
DOI:10.3109/00016347009158013
出版商:Blackwell Publishing Ltd
年代:1970
数据来源: WILEY
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| 2. |
An Evaluation of the Possible use of Prostaglandin E1, E2and F2αfor Induction of Labour |
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Acta Obstetricia et Gynecologica Scandinavica,
Volume 49,
Issue S5,
1970,
Page 9-17
U. Roth‐Brandel,
M. Adams,
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摘要:
The stimulatory effect on uterine contractility of prostaglandin E1, E2and F2αwas studied in 29 term pregnant women and 4 midpregnant volunteers admitted for therapeutic abortion. The substances were administered intravenously and uterine contractility recorded by measuring the amniotic pressure. In a careful analysis of the quantitative tracings it was found that suitable doses of the prostaglandins induce efficient uterine contractions. However, these contractions are characterized by a comparatively low intensity in relation to frequency and also occurrence of incoordinated contraction complexes. The results do not support the opinion that the prostaglandins are superior to oxytocin for induction of labour at term pregnancy
ISSN:0001-6349
DOI:10.3109/00016347009158014
出版商:Blackwell Publishing Ltd
年代:1970
数据来源: WILEY
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| 3. |
Effect of Intravenous Administration of Prostaglandin E1and F2αon the Contractility of the Non‐Pregnant Human Uterus in Vivo |
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Acta Obstetricia et Gynecologica Scandinavica,
Volume 49,
Issue S5,
1970,
Page 19-25
U. Roth‐Brandel,
M. Bygdeman,
N. Wiqvist,
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PDF (458KB)
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摘要:
The effect on uterine contractility of prostaglandin E1(PGF2α) and F2α(PGF2α) was studied in 19 non‐pregnant women. Uterine motility was recorded by the micro balloon method and the prostaglandins administered by single intravenous injections in increasing doses.1Doses above threshold levels of both PGE1and PGF2αalways resulted in stimulation of the uterus primarily in terms of tone elevation.2A short drop of tone during 40–60 seconds immediately following the injection was obtained in a few experiments after high doses of PGE1. This response preceeded the normal stimulatory effect.3The threshold dose for PGE1was approximately 20 μg and that for PGF2αaround 50 μg or lower.4The non‐pregnant uterus is probably more sensitive to PGF2αthan the midpregnant uterus.5The number of experiments were too few to allow conclusions as to differences in uterine sensitivity during the various phases of the menstrual cycle.6Administration of oxytocin and vasopressin did not enchance the uterine sensitivity to stimul
ISSN:0001-6349
DOI:10.3109/00016347009158015
出版商:Blackwell Publishing Ltd
年代:1970
数据来源: WILEY
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