ISSN:0001-6349    

DOI:10.3109/00016349209021066

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016349209021067

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016349209021068

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The aim of this study was to compare the macroscopic evaluation of peritoneal abnormalities suspected of endometriosis with the histologic examination of the tissue. Peritoneal biopsies from 152 patients investigated for gynecological problems (94) or undergoing tubal sterilization (58) were taken from macroscopically abnormal peritoneum, and examined for the presence of endometriosis. Endometriosis was histologically confirmed by the presence of both endometrioid glands and stroma. Endometriosis was confirmed in 78 of the patients (51%). If the diagnostic criteria were extended also to include endometrioid stroma lacking glands, but containing iron pigment and/or hemorrhage, 82 patients (54%) were positive for endometriosis. Endometriosis was histologically confirmed in 76% of pigmented lesions, in 57% of clear or red papules, in 12% of peritoneal pockets, and in 16% when only fibrosis or scarring was observed. Half of the samples with confirmed endometriosis exhibited cyclic activity. The reproducibility of the histologic evaluation was satisfactory. A high rate of negative biopsies emphasizes the need of taking biopsies from peritoneal lesions suspected of endometriosis for confirmation of the diagnosis.

ISSN:0001-6349    

DOI:10.3109/00016349209021069

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Urinary albumin concentration (UA) and albuminlcreatinine ratio (UA/UC) in early morning specimens were assayed in 225 consecutive pregnant women at 20, 26, 28 and 30 weeks of gestation. 193 did not develop preeclampsia (control group), 14 developed preeclampsia later (preeclamptic group), Y were excluded and Y dropped out. Reference intervals of UAand UA/Ucof healthy pregnant women (wk 20–30) was obtained. A statistically significant increase in urinary albumin excretion was observed with increasing gestational age as a normal phenomenon. There was no significant difference in the values of UAand UA/UCin the preeclamptic group when compared with the control group at the same stage of gestation. This indicates that microalbuminuria cannot be used as a predictor of preeclampsi

ISSN:0001-6349    

DOI:10.3109/00016349209021070

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The management and outcome of 46 pregnancies, 37 triplets, 7 quadruplets and 2 quintuplets, were analysed. Management of pregnancies, initiated upon diagnosis of multiple pregnancy, included bed rest, β‐mimetic agents, dexamethasone late in the second trimester and selective cerclage. The mean gestational age at labor was 235 days in triplet pregnancies, 241 for quadruplets and 220 days for quintuplets. Fifty‐four percent of the deliveries were by cesarean section and the remainder per vaginam. The mean weight of the neonates was 1809 g for the triplets, 1837 g for quadruplets and 1284 g for the quintuplets. The mean overall Apgar score was 8.13, total perinatal mortality 14.8% and 9.4% in cases more than 28 weeks. There was no statistically significant difference in the outcome for triplets born vaginally or by cesarean section. In recent years there has been a pronounced reduction in neonatal mortality, dropping from 17.3% during 1970–78 to 5.9% from 1979 to 1983 (p<0.05), probably due to the improved neonatal tre

ISSN:0001-6349    

DOI:10.3109/00016349209021071

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Thirty term pregnant women with one previous cesarean section and with unripe cervices were given 0.5 mg prostaglandin E2in gel strictly intracervically for cervical ripening and labor induction. Fifteen out of these 30 women (50%) were vaginally delivered within 24 hours. The cervical ripeningllabor induction was considered a failure in two women. In one woman, an episode of hypercontractility was registered. After tocolytic therapy the uterine activity was normalised and the woman had a normal vaginal delivery. The frequency of cesarean sections was 8/30 (27%). At the operations no insufficencies in the uterine scars were noted. Conclusively, strict intracervical application of 0.5 mg prostaglandin E2in gel can be used for cervical ripening and labor induction also in women with one previous cesarean section.

ISSN:0001-6349    

DOI:10.3109/00016349209021072

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A questionnaire was sent to every tenth (n= 302) general practitioner in Norway. The physicians were to indicate their choice of antibiotic regimen for the treatment of genital chlamydial infections in women. Sixty‐nine percent of the practitioners responded. The choice of treatment varied widely between the respondents. Forty‐two different regimens were used for chlamydial cervicitis, 34 for cervicitis in pregnancy and 63 for probable pelvic infection. Of the prescribed treatments for these three diagnoses 14%, 5% and 46%, respectively, were compatible with the advice of the World Health Organization or the Centers for Disease Control. For the three previously mentioned diagnoses 49%, 79% and 43%, respectively, of the practioners would prescribe an antibiotic in either smaller doses, fewer daily doses or shorter duration than recommended. There is an urgent need to improve and standardize Norwegian general practitioners' treatment of chlamydial infection in wo

ISSN:0001-6349    

DOI:10.3109/00016349209021073

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Fifty‐one consecutive, previously untreated patients with FIGO stage III or IV epithelial ovarian carcinoma were enrolled in a prospective study over a period of 7 years (1981–1988). Significant improvement has been noted in patients with advanced ovarian cancer following the administration of modified PAC 1 (adriamycin, cytoxan and cyclophospha‐mide) immediately following primary debulking surgery (within 24 hours) and repeated for 11 monthly cycles. A second look operation was found as an important prognostic indicator. Thirty‐one patients (all Stage III) completed the chemotherapy course and were eligible for second look operation. Of these, 21 patients (68%) showed negative second look. Of the patients with negative second look, 17 of 21 (81%) are alive with a mean survival of 61 months (range 19–103 months) after diagnosis. Among those with positive second look only 3 of 10 are alive with a mean of 41 months after diagnosis. The remaining 20 patients (13 stage III and 7 stage IV) did not undergo second look laparotomy. Only 2 of these 20 patients are alive with a mean of 35 months after diagnosis. Other factors of significant importance were: age and completion of chemotherapy course. Patients appeared to benefit from the combined regimen of optimal debulking surgery, completion of 12 courses of chemotherapy with the first course administered immediately after surgery and second look operation. Tumor type or histologic gradc did not seem to influence results. The early use of chemotherapy was well tolerated and toxicity was minimal and a

ISSN:0001-6349    

DOI:10.3109/00016349209021074

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Aim and objective: Because the findings of epidemiologic studies of the relationship between oral contraceptive use and cervical cancer have not been consistent, we reanalyzed the relationship.Design: Meta‐analysis of studies published to date.Setting and subjects: Papers were located by searching the MEDLINE data base, supplemented by a hand search of all the references in the articles recovered.Measurements: Studies were graded as to quality. Two meta‐analyses were performed: one including all the studies gathered and one including methodologically acceptable studies only. The method of Woolf was used to combine relative risks. Heterogeneity of the effect was assessed.Main results: Fifty‐one published studies were collected: 21 case‐control, 18 cross‐sectional, and 12 cohort designs. Twenty‐one of these were considered as methodologically acceptable, but only 18 could be pooled. The main results observed were: relative risks was 1.52 (1.3–1.8) for dysplasia, 1.S2 (1.3–1.8) for carcinoma in situ, and 1.21 (1.1–1.4) for invasive cancer. A significant linear dose‐response effect was observed in dysplasia, carcinomain situ, and invasive cervical cancer. Heterogeneity of the effect was present in some of the former estimates.Conclusions: Oral contraceptive use may be a risk factor for all stages of the natural history of cervical cancer, which may imply an initiator effect. Limitations to this res

ISSN:0001-6349    

DOI:10.3109/00016349209021075

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY