ISSN:0001-6349    

DOI:10.3109/00016348109157803

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348109157804

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The present article describes some of the factors regulating progesterone action in mammalian uterus. The main emphasis is laid on the role of cytosol receptor concentrations in the ultimate expression of progestin action. In addition, recent findings on the regulation of uteroglobin (a progesterone‐stimulated rabbit uterine protein) are dealt with, especially in the light of estrogen‐progestin interaction in this regulation. The current evidence suggests that estradiol is able to mimic and modify progesterone action in a dose‐related fashion: small doses of estradiol potentiate the progesterone effect, whereas higher concentrations of this steroid almost completely block expression of progestational response. These actions of estradiol seem to occur via mechanisms distal to progesterone receptor synthesis, since the doses of estradiol which most markedly inhibit progesterone action on uteroglobin synthesis bring about a significant increase in uterine progesterone receptor concentra

ISSN:0001-6349    

DOI:10.3109/00016348109157805

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348109157806

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348109157807

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348109157808

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Since human mammary cancer can be transplanted into nude mice, this makes possible thein vivostudy of relations between hormone dependency and the steroid hormone receptor content of the tumors. The macroscopic growth curve of the transplanted tumors during endocrine therapy will reflect the hormone dependency. The results can be compared with successive steroid hormone receptor determinations in the tumor tissue.

ISSN:0001-6349    

DOI:10.3109/00016348109157809

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

This paper reviews the theoretical background for the use of progestins in advanced breast cancer and the clinical experience obtained from 13 major studies.The average rate of response is about 30%, with somewhat higher rates when the dominant site of disease is localized to soft tissue and to bones, compared with viscera. Furthermore it seems that cross resistance between progestin therapy and other endocrine therapies is only partial. However, response rates related to previous therapy and to important prognostic variables such as age of the patient, disease‐free interval and hormone receptor content of the tumor tissue are poorly elucidated. Only limited data are available concerning response rate in relation to dose and route of administration and data from prospective randomized trials to analyze these relations are still lacking.Considering the only modest side effects of treatment with progestins and the clinical and theoretical evidence favoring a mode of action different from that of other endocrine therapies, progestins are drugs with interesting qualities. Therefore future controlled studies with progestins alone or in combination with other systemic therapies should be carried out to establish the therapeutic efficacy of progestin therapy in primary and advanced diseas

ISSN:0001-6349    

DOI:10.3109/00016348109157810

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348109157811

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348109157812

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY