摘要:

A group of 99 patients, who underwent total hysterectomy because of carcinomain situof the cervix uteri between 3 and 57 days after cervical cone biopsy, were compared with a control group of 130 patients who were subjected to hysterectomy because of uterine fibroids with no preceding biopsy. A significantly increased frequency of wound infections was found in the cone‐biopsy‐hysterectomy group, 23.2% as compared with 6.2% in the control group. Furthermore a significant increase in febrile morbidity was found in the cone‐biopsy‐hysterectomy group, 31.3% as compared with 10.8% in the control group. In the cone‐biopsy‐hysterectomy group wound infections only occurred when the time interval between the two operations was between 3 and 14 days. With an interval of 15 days or more no wound infections were found. No relationship could be established between the febrile morbidity rate and the cone‐biopsy‐hysterectomy interval. Other complications were similar in both groups. The most frequent complications were urinary tract infections and pneumonia. No deaths occurred. It is recommended that hysterectomy should not be performed until at least two weeks after a cone biopsy of the cervix, in order to avoid the risk of wound infection which was 4 times commoner than in our

ISSN:0001-6349    

DOI:10.3109/00016347209154961

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Following a dislocation of the lower edge of the nasal septal cartilage from the furrow in the pre‐maxilla and vomer (Figs. 1, 2) the cartilaginous outer nose is often twisted and the support is poor (Figs. 4a, b). In 7% of the cases no deviation is evident unless a compression‐test is carried out (Fig. 4b). This procedure is recommended in the routine examination of newborn infants. If twisting is found the infant should be examined by a specialist in ear, nose and throat diseases. 141 cases of dislocation of the nasal septal cartilage were found in a series of 9 707 living newborn infants (1.45%) (Fig. 5). However, in a series of 907 newborn infants all examined rhinologically 29 cases were found (3.19%) (Fig. 6). Two thirds of the cases are apparently caused by trauma during pregnancy and the early stages of labour. They are equally distributed between right and left. One third of the cases are caused by trauma solely during internal rotation, which in the L.O.A.‐presentation causes a dislocation of the inferior edge to the right, in the R.O.A.‐presentation to the left (Figs. 10, 11, 12). The condition occurred significantly more commonly in firstborn infants but the reason for this was not evident from the analyses of the data. It was also more common in multiparae if second‐stage of labour was prolonged beyond 15 min (Table VIII). Therefore it is suggested that the second stage should not exceed 15 min in multiparae. The dislocation does not reduce spontaneously. The results obtained after reduction according to the method of Metzenbaum (Fig. 4c) are good (Fig. 13), and the procedure can be carried out under local an

ISSN:0001-6349    

DOI:10.3109/00016347209154962

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The responses of human fetal catecholamine storing tissues, the paraganglia and adrenal medulla to severe oxygen deficiency were tested by using perfusion techniques. The changes in catecholamine content of the target organs were registered by demonstrating the formaldehyde induced fluorescence exhibited by catecholamines. A definite decrease in the intensity of the catecholamine specific fluorescence was observed regularly in the paraganglia after 10–15 min hypoxia. Only very slight changes occurred occasionally in the corresponding adrenal medullae. The role of the target organs and the catecholamine release during oxygen deficiency are discusse

ISSN:0001-6349    

DOI:10.3109/00016347209154963

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Plasma oestriol concentrations were studied in 48 women with prolonged pregnancies. In all, 177 studies were made from the 40th to 46th weeks. There was a significant fall in plasma concentration from the 40th to 46th weeks contrasting with the significant rise from the 24th to 42nd weeks of normal pregnancy. There was a correlation between the plasma concentration and urinary excretion of oestriol, as there is in normal pregnancy from the 24th to 42nd weeks, but there was a significant difference in the correlations (at these two stages) pointing to an increased renal clearance of oestriol during prolonged pregnancy. It is postulated that this phenomenon might depend on a proportionate increase in the production of the conjugate oestriol‐16‐glucosiduronate, which is more rapidly excreted by the kidneys than oestriol‐3‐sulphate, and which reflects a reduced metabolic activity. Urinary oestriol excretion, however, falls during prolonged pregnancy, despite the postulated increased clearance. It is concluded, therefore, that oestriol production, which reflects the function of the feto‐placental unit, is, in fact, reduced during prolonged pregnancy. Plasma oestriol studies would appear, therefore, to give a better physiological control of prolonged pregnancy than urinary oestrio

ISSN:0001-6349    

DOI:10.3109/00016347209154964

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

In order to assess the value of laparoscopy as a routine procedure in suspected ectopic pregnancy (E.P.) a study was made on 489 laparoscopies performed on this indication. The laparoscopy was technically successful in 478 cases (97.8%). Only one of 166 E.P. was overlooked. A false diagnosis of E.P. was made in 6 of 312 women without ectopic gestation. Thus, the total diagnostic accuracy in successful laparoscopies was 98.5%. Combining swiftness and exactitude and covering the whole field of different conditions where a suspicion of E.P. arises, laparoscopy is superior to other diagnostic procedures. It is concluded that routine use of laparoscopy in suspected E.P. is justified. Apart from fulminant cases in which it is contraindicated, laparoscopy should be regarded as the method of choice to diagnose as well as to exclude E.P.

ISSN:0001-6349    

DOI:10.3109/00016347209154965

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

In earlier investigations the author demonstrated that the head to cervix pressure both during and between contractions in labour is greatest at the equator of the foetal head and that the head to cervix pressure decreases towards the lower pole of the foetal head. These pressure conditions explain the biomechanics of cervical dilatation during labour under different conditions. The author has used small flat strain gauge receptors sited between the foetal head and the uterine wall. In the present investigation the head to cervix pressure was also measured above the equator of the foetal head. Between the contractions the head to cervix pressure decreases progressively above the equator of the head and finally the amniotic fluid pressure is measured. In some cases, especially primi‐gravidae, the head to cervix pressure curves rise very steeply at the beginning of a contraction but as the amniotic pressure approaches its maximum, the head to cervix pressure decreases and ultimately falls to the same level as the amniotic fluid pressure. In other women, especially multigravidae, the increase of the head to cervix pressure at the beginning of the contraction is less, but usually the pressure at the beginning of the contraction increases more rapidly than the head to cervix pressure below the equator. During the contractions the amniotic pressure was measured first at high level and at higher amniotic pressure successively towards the equator. The findings are supported by model experiments using a wooden sphere over which a rubber sheath has been drawn. The investigations explain the engagement of the foetal head in the lower part of the uterus. The importance of the engagement of the foetal head when the vertex presents is related to the influence upon the friction between the foetal head and the uterine wall and the mechanism of cervical dilatation. The engaged foetal head prevents the outflow of amniotic fluid after rupture of the membranes and minimises the risk of prolapse of the umbilical cor

ISSN:0001-6349    

DOI:10.3109/00016347209154966

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

This report concerns a patient with preinvasive cervical carcinoma and atypical hyperplasia in the endometrium. Separate chromosome analyses were performed on foci of moderate dysplasia and carcinoma in situ in a cone biopsy, and on material obtained from two curettage specimens. The chromosome picture in the two cervical areas differed and indicated a clonal evolution. The two curettage specimens were at variance with the cervical epithelium. The cytogenetic difference between squamous and columnar dysplasia is discussed in relation to the possible pathway of development of malignancy.

ISSN:0001-6349    

DOI:10.3109/00016347209154967

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Thirteen women with adenocarcinoma of the endometrium were treated with standardized doses of hydroxyprogesterone caproate for 3 weeks. Histological and histochemical studies of tumour tissue were performed before and after the treatment. Most of the well differentiated carcinomas showed secretory and acantho‐matous changes after the treatment, whereas such changes were more rarely seen in tumours with low degree of differentiation. There was a great variability in the enzyme pattern. Alkaline phosphatase activity seemed to decrease during the treatment, whereas acid phosphatase and adenosine triphosphatase activities were mostly unaffected. The serum levels of LH decreased, whereas the plasma level of corticoids and the urinary excretion of oestriol and pregnandiol showed no definite changes during the treatmen

ISSN:0001-6349    

DOI:10.3109/00016347209154968

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

In Denmark, 94 cases of trophoblastic disease were classified as choriocarcinoma (CHC) or “probably CHC” during the period 1940–1969. All these cases were subjected to a reappraisal in the study presented here. Based on the criteria laid down by the Armed Forces Institute of Pathology, 50 of the cases were classified as CHC, 18 as invasive moles (IM), and 26 as other trophoblastic proliferations (OTP).Among the CHC patients, 30 died of generalized disease and one from postoperative complications. Eighteen patients (36%)—10 of them with metastases—recovered. Four of these patients have been observed for 2–5 years and 14 for more than 5 years. Finally, one patient has still active disease.Forty‐four patients suffering from IM (18) or OTP (26) were cured of their disease, including 5 with metastases. Determination of chorionic gonadotrophs was performed in 88 of the 94 patients at the time of the original diagnosis. Based on the findings at the re‐evaluation, the frequencies of IM and CHC were one case per 126 000 and 49 000 births, respectively. The ratio of IM to CHC was 1 to 2.6. As compared with Norway and Sweden, Denmark seems to have the lowest incidence of these diseases. During the years 1943–1963, CHC accounted for approx. 0.03% of all malignant neoplasms in Danish females.The study reported here forms the basis of subsequent immunologic investigations into the transplantation aspe

ISSN:0001-6349    

DOI:10.3109/00016347209154969

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The concentration, composition and fatty acid components of amniotic fluid phospholipids were determined in samples obtained at term and during the second trimester of gestation. The mean concentration of total phospholipids was significantly higher at term than during the second trimester. There was also a highly significant increase in the ratio phosphatidylcholine/sphingomyelin at term. Concomitantly the proportion of palmitic acid in the phosphatidylcholines rose to very high levels. Changes in the same direction were recorded in the fatty acid composition of the phosphatidylethanolamines. The present results indicate that analysis of amniotic fluid phospholipids may be of clinical significance in determining the pulmonary maturity of the foetus.

ISSN:0001-6349    

DOI:10.3109/00016347209154970

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY