ISSN:0001-6349    

DOI:10.3109/00016349209021047

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016349209021048

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Torsion of the pregnant uterus is defined as rotation more than 45° around the long axis of the uterus. Uterine torsion is observed in all age groups of the reproductive period, in all parity groups, and at all stages of pregnancy. Torsion from 60° to 720° has been described. It is not possible to clarify why uterine torsion occurs, but numerous abnormalities have appeared with uterine torsion; most often, abnormal fetal presentation, myoma uteri and uterine malformations. The most usual symptoms of uterine torsion are birth obstruction, abdominal pain, vaginal bleeding, shock, and urinary and intestinal symptoms. Elcvcn percent arc asymptomatic. The treatment in the earlier months of pregnancy is immediate laparotomy and detorsion of the uterus and, if practicable, adjunct surgery to climinatc the possible etiologic factors. Near term or during labor ccsarcan section is carried out, and elimination of the possible etiologic factors.The fetal and maternal mortality rates since 1976 arc 12% and 0% respective

ISSN:0001-6349    

DOI:10.3109/00016349209021049

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Changes of energy inctaholism in maternal leukocytes were studied longitudinally in 33 normal term pregnancies at 12, 20 and 36 weeks of gestation and 40 days post partum. Nutrient intakes were calculated from 3‐day weighed food records at the same periods. Women tended to decrease their mean dietary intakes of energy and of most nutrients from early to late pregnancy. Glucose‐6‐P dehydrogenase (G6P‐DH), pyruvic kinase (PK) and adenylate kinase (AK) activities rose significantly after the 12th week of pregnancy, reaching maximal values at week 20. The following period up to week 36 showed a significant decrease that continued in the puerperium, when their values were lowest. Adenine nucleotidc contents and protein/DNA ratio followed a different pattern. A significant increase was also observed from weeks 12 to 20, remaining without changes during the second half of gestation, and falling at puerperium. The PK and AK activities showed a positive correlation with energy intake at 36 weeks of gestation and AK activity was negatively correlated with folic acid intake in the middle of pregnancy. At week 20, PK activity showed a positive correlation with both head circumference and body mass index of the newborn. There was also a correlation between protein/DNA ratio and head circumference at the 36th week of gestation. These findings may suggest a relationship between the metabolism of maternal leukocytes, and fetal development i

ISSN:0001-6349    

DOI:10.3109/00016349209021050

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

From 1983 to 1989, 147, 068 pregnancies were analyzed for allo‐immunization against erythrocyte antigens. Approximately half of the cases were due to immunization against factor D and the others were due to allo‐immunization against other antigens (K, c, E, etc.). In 61 cases exchange transfusion of the newborn was needed and in 115 cases diagnostic amniocentesis was done during pregnancy. Intrauterine transfusions were performed in 10 cases. Fetal and neonatal mortality was 4% in these moderate to severe cases, all due to immunization against D. Immunization against D was due to failure to give immunoglobulin anti‐D in about 2/3 of the cases. Systematic prophylactic treatment with anti‐D during pregnancy would probably not be cost‐effective in this p

ISSN:0001-6349    

DOI:10.3109/00016349209021051

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We report the results of a large‐scale trial with mifepristonc (RU 486) followed by the administration of a prostaglandin (PG) analogue for the medical termination of early pregnancy. Altogether, 16,173 patients from 300 centers were evaluated. 48 women (0.3%) were lost to follow‐up prior to, and 416 (2.6%) after the PG administration, and therefore the efficacy was evaluated in 15,709 women. Overall. the success rate was 95.3%. with no statistical difference regarding the nature and dose of PG used. The median duration of bleeding was 8 days, being 12 days or less in 89.7% of the women. Bleeding was significant cnough to necessitate a vacuum aspiration or a dilatation and curettage in 0.8% of the cases. A blood transfusion was necessary in 0.1% of the women (11 patients). Serious cardio‐vascular side‐effects were reported in 4 cases after the PG (sulpro/tonc) injection: they consisted of one acute myocardial infarction attributed to a coronary spasm. and in marked hypotension in the other 3 woman. All patients recovered uneventfully. In conclusion, RU 486 followed by a PG analogue provides an efficient and safe medical alternative to surgery for early pregnancy termination, provided that the recommended protocol is adequately followed and the contraindications to prostaglandins are re

ISSN:0001-6349    

DOI:10.3109/00016349209021052

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

420 pregnancies were recorded between 1962 and 1987 among 202 women working for at least one month in day nurseries during 1984. During that time 230 pregnant mothers had worked as childminders in day nurseries (‘exposed’ pregnancies). The remaining 190 pregnancies were classified as ‘unexposed’. 27 spontaneous abortions were exposed and 7 unexposed corresponding to abortion rates of 11.7% and 3.9%, respectively, which is a significant difference. Also ‘threatened’ abortions during the first trimester of pregnancies ending up in live‐born children were accumulated in exposed pregnancies, and the miscarriage rate was possibly increased in unexposed pregnancies of women with their own children in day nurseries. Significant differences were not observed with regard to premature birth, congenital malformations, number of live‐born children and sex ratio of live‐born children. The cause of the increased frequency of spontaneous and ‘threatened’ abortions in exposed pregnancies could

ISSN:0001-6349    

DOI:10.3109/00016349209021053

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Chemotherapy was given as initial therapy to 23 patients with previously untreated early and advanced cervical carcinoma. A combination of cisplatin and VP‐16 was given in squamous cell carcinoma, and cisplatin, cpirubicin and cyclophoshamide in adcnocarcinoma in one to three courses at 4‐week intervals. The overall clinical response rate to initial chemotherapy was 78% (80′% in early and 78% in advanced disease). A complete response was achieved in 3 (13%) and a partial response in 15 (65%) patients. To obtain independent information on treatment response serial tumor marker determinations were used in patients with elevated pretreatment levels. Squamous cell carcinoma antigen (SCC) responded to chemotherapy by decreasing levels in 91% of the cases. carcinoembryonic antigen (CEA) in 33%, CA 125 in 83%, and tumor‐associated trypsin inhibitor (TATI) in 50%, respectively. These results show that cervical carcinoma is a drug‐responsive tumor and that SCC and CA 125 can be used as an aid in the cvaluation of response to chemotherapy. Initial chemotherapy appears be of value by reducing tumor volume thus providing better conditions for surgery and rad

ISSN:0001-6349    

DOI:10.3109/00016349209021054

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We report a rare case of non‐Hodgkon lymphoma located in the vulva. The diagnosis was supported by the cytological anomalies in material obtained by fine needle aspiration. The tumor was removed with wide excision, and the paticnt was alive and in good health ten months after surger

ISSN:0001-6349    

DOI:10.3109/00016349209021055

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Three cases of pheochromocytoma associated with pregnancy are reported. Two patients had adrenal pheochromocytoma coexistent with normal pregnancy and one patient had a bladder pheochromocytoma coexistent with molar pregnancy (gestational trophoblastic disease). The diagnosis was made antenatally in the two normal pregnancy patients, both underwent planned tumor resection, one at mid‐trimester, complicated by postoperative miscarriage, while the other had tumor resection during cesarean section at term. Bladder pheochromocytoma, preoperatively mistaken for invasive trophoblastic tumor, was resected at the time of planned abdominal hysterectomy for molar pregnancy, pheochromocytoma was recognized only after microscopic study of the rcscctcd bladder tumor. The three patients survived with no evidence of diseas

ISSN:0001-6349    

DOI:10.3109/00016349209021056

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY