摘要:

Abstract.The orthostatic pulse reaction, physical working capacity on the bicycle ergometer, total haemoglobin content and the heart volume in the supine position were determined on two different occasions in ten primigravidae, all of whom were in the first trimester of pregnancy at the first examination. The second examination was performed 2 weeks after legal abortion. The orthostatic reaction on standing upright for a period of 8 min was more pronounced during pregnancy than following abortion. The physical working capacity at a pulse rate of 170/min was lower during pregnancy than 2 weeks after abortion. There was no difference in the heart volume in the supine position, nor in the total haemoglobin content at the times in question. The circulatory haemodynamics seem to be changed in early pregnancy so as to resemble those of the vasoregulatory asthenia syndrome.

ISSN:0001-6349    

DOI:10.3109/00016347409156881

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.Cervical blood flow was measured by the local hydrogen gas clearance method in 15 patients with untreated carcinoma of the uterine cervix and in 16 patients six to eight weeks after radium irradiation. Mean cervical blood flow was 75.5 ml/min. 100 g in the untreated group and 92.4 ml/min. 100 g in the treated group.

ISSN:0001-6349    

DOI:10.3109/00016347409156882

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.A group of 17 healthy women, of whom 9 had a predisposition to diabetes, were studied for five consecutive menstrual cycles with regard to the effect of an oral combined contraceptive containing 0.5 mg norgestrel and 0.05 mg ethinylestradiol (Eugynon®). The fasting concentration in the serum of triglycerides, free fatty acids and insulin together with the respone values during i.v. glucose toleracne for free fatty acids and insulin were estiamted. The tests were performed at midcyle n the cycle prior to, in two ycles during and in the second cycle after cessation of the drug administratino. The drug was administered daily from the fifth to twentyfifth day of the cycle in the two cycles. Thus each subject served as her own control. Statistical analysis of the results showed a significant increase in the fasting values of teh serum triglycerides during hormonal administration in those predisposed to diabetes, but unchanged values in those not so predisposed. The fasting values of the serum free fatty acids were, for the series as a whole, significantly lower in the second cycle of administration. There was no significant difference with regard to the predisposition to diabetes, but a tendeny to unchanged values in those predisposed to diabetes and lower values in those not predisposed. The fasting values of the serum insulin showed no changes and no difference with regard to predisposition to diabetes. The response to i.v. glucose injection showed, for the free fatty acids, no significant changes during hormonal administration, but the fasting values also had a tendency to unchanged values for thsoe predisposed and lower values for those not predisposed to diabetes, during hormonal administratino. The response values of serum insulin were, for the series as a whole, significantly higher during hormonal administration, those predisposed to diabetes showed 60 min after glucose injection significantly higher values than those not so predisposed during hormonal administration. The results are discussed and compared to the findings of other investigators. Possible modes of action with regard to the increase in triglycerides in thsoe predisposed to diabetes are discussed. The study indicates, but does not prove, that in women predisposed to diabetes there is an increased risk of the development of hypertriglyceridaemia and consequent disease with the administration of the oral contraceptive studied

ISSN:0001-6349    

DOI:10.3109/00016347409156883

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.The side chain cleavage of cholesterol and of pregesterone in rat testis preparations is stimulated in vitro by 0.5–2.0 × 10−3M clomiphene citrate. The mechanism is thought to be analogous with that demonstrated by Hagerman and co‐workers (1966) for the stimulation of placental ring A aromatization. The results seem to give additional support to the possibility of direct action of the drug on the steroidogenic organs i

ISSN:0001-6349    

DOI:10.3109/00016347409156884

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.Twenty‐four full‐term nulliparae and their babies were studied. Twelve received lumbar epidural analgesia with bupivacaine (Marcain‐adrenalin®) and twelve conventional obstetrical analgesia with meperidine (Petidin®), chlorpromazine (Hibernal®), nitrous oxide and a pudendal nerve block with prilocaine (Citanest®). The acid‐base balance was determined in fetal and maternal blood during labour and in neonatal blood after birth. The newborn infants were placed in incubators after birth and several clinical parameters were recorded during the first two hours. Epidural analgesia to the mothers resulted in a lower degree of metabolic acidosis than conventional obstetrical analgesia. The clinical and blood‐chemical parameters recorded in this study indicated no harmful effects on the newborn infants after epidural analgesia t

ISSN:0001-6349    

DOI:10.3109/00016347409156885

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.Blood sugar determinations were made four times daily on non‐diabetic pregnant and non‐pregnant women admitted to hospital for reasons not supposed to influence carbohydrate metabolism. All blood sugar values were found to decrease during pregnancy. The fasting blood sugar decreased from 78 to 65 mg%, and the daily mean value from 99 to 80 mg%. The increase in blood sugar after the main meal of the day was found to be smallest in late pregnancy. The results indicate a progressive change in carbohydrate tolerance during pregnancy. Some implications of the results on the management and outcome of diabetic pregnancy are discus

ISSN:0001-6349    

DOI:10.3109/00016347409156886

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.Norepinephrine (NE) metabolism in 18 fresh, healthy and full‐term placentas was studied. It was found that, in vitro, metabolism takes place in an oxygen atmosphere mainly through the action of monoamineoxidase (MAO). A reduction in the oxygen component pressure weakened the activity of MAO but not significantly that of catechol‐O‐methyltransferase (COMT). Increase in acidity also reduced MAO activity, but its fall to a level as low as pH 8.4 did not significantly affect the activity of either enzyme. After the addition of MgCl2and Sadenosyl methionine a significant increase in the NMN share during 10 min incubation was noted. However, these additions did not improve the decomposition of NE but reduced the proportion of DOMA. Pyrogallol failed to inhibit COMT but produced a significant reduction in the proportion of dihydroxymandelic acid (DOMA). Increase in acidity and CO2and the fall in O2content, all found in the placenta in connection with foetal asphyxia, individually reduced the decomposition

ISSN:0001-6349    

DOI:10.3109/00016347409156887

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.The content of the low‐molecular weight protein β2‐microglobulin and albumin was measured by immunochemical methods in amniotic fluid from 136 patients in the 13th to the 43rd week of pregnancy. Parallel estimations of β2‐microglobulin in maternal plasma were made in the majority of patients. Some samples of cord serum and urine from the newborn were also analysed. In normal patients the levels of β2‐microglobulin followed the albumin pattern with a peak value around the 24th week and a gradual decrease during the last trimester. In contrast to other proteins β2‐microglobulin showed higher levels in amniotic fluid than in maternal plasma. During the last trimester levels in maternal plasma exhibited a significant increase. Levels in cord serum were higher than in amniotic fluid. Urine from the newborns contained at least 5 times the amount previously found in adults. The results indicate that β2‐microglobulin in amniotic fluid is largely derived from the fetus itself. Patients with pregnancies complicated by haemolytic disease showed significantly higher levels in amniotic fluid than normal patients for comparable periods but the levels showed no close correlation with the degree of fetal involvement. The ratio of β2‐microglobulin to albumin in amniotic fluid was elevated in patients with fetal haemolytic disease. The albumin content showed no significant differences between the clinical groups but tended to decrease more rapidly during the last weeks of pregnancy in patients with fetal haemolytic disease. Further studies of β2‐microglobulin might supply important information about the transfer mechanisms of amniotic fluid proteins and also permit studies of some physiological and pathological

ISSN:0001-6349    

DOI:10.3109/00016347409156888

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.The “pregnancy zone” protein (PZ) was demonstrated in the sera of 311 out of 350 pregnant women at term (88.9%). The lack of demonstrable PZ was studied in relation to parameters reflecting fetal maturity (birth weight, placental weight and gestational age). Birth weight was significantly lower among infants of women lacking PZ, while for placental weight and gestational age no significant correlation was found with PZ. Furthermore no apparent correlation was found between the lack of PZ in maternal serum and maternal age, parity and previous abortion. The results indicate that lack of PZ in the serum of pregnant women at term is a normal phenomenon compatible with normal pregna

ISSN:0001-6349    

DOI:10.3109/00016347409156889

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.The occurrence of ovulation was determined in 21 healthy women after full term delivery by quantitation of the serum progesterone, basal body temperature and cervical mucous ferning tests. The basal body temperature was recorded daily starting during the first week postpartum and serum progesterone estimations and cervical mucus ferning tests were performed at weekly intervals starting after the first month postpartum. All patients were followed until the first postpartum menstruation, and thereafter 18 women continued the study till the second menstruation. The women investigated breast‐fed their infants for periods ranging between one and 14 weeks. Ovulation during lactation occurred in none of the cases. After weaning, when menstruation was resumed, ovulation occurred less frequently in patients who lactated for a short period as compared to those who lactated for relatively longer. When the duration of postpartum amenorrhoea was short ovulation preceded the first menstruation less frequently than in women with relatively longer postpartum amenorrhoea. The incidence of ovulation before either the first or the second menstruation was lower in primiparae than in multi‐parae. None of 12 women aged 25 years or less ovulated before the first menstruation while 7 ovulated before the second menstruation. In women above 25 years of age, ovulation occurred in 6 out of 9 before the first menstruation and in 5 out of 6 before the second menstruation. The basal body temperature and the cervical mucous ferning tests were equally adequate to detect ovulation as the serum progesterone concentrat

ISSN:0001-6349    

DOI:10.3109/00016347409156890

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY