ISSN:0001-6349    

DOI:10.3109/00016348409156970

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348409156971

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348409156972

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Abstract.A histochemical method for the detection of steroid‐binding sites in very small tissue specimens was evaluated. Competitive binding experiments proved the method to be sufficiently specific. When applied to endometrium and endometriotic tissue obtained simultaneously from the same patient, a distinct binding was found both in the epithelial structures and in the stroma. The binding pattern in endometriotic glands resembled that in the endometrium. The study seems thus to support the conclusion that endometriotic lesions contain specific binding sites for estrogen and progesterone and that their distribution seems to be similar to that found in the endometrium from the same patien

ISSN:0001-6349    

DOI:10.3109/00016348409156973

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348409156974

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Abstract.To study peritoneal fluid (PF) prostaglandin (PG) in infertile women, 6‐keto‐PGFla (a breakdown product of prostacyclin) and thromboxane B2 (T × B2) (a metabolite of T × A2) were assayed with radio‐immunoassays from PF samples collected at laparascopy from patients with endo‐metriosis (n = 29), unexplained infertility (n = 13) and from women with normal pelvic organs (n = 25). The concentrations of 6‐keto‐PGFla and T×82 in PF were increased (p<0.05) in endometriosis and unexplained infertility, as compared with the corresponding levels in the controls. In patients with endometriosis, both 6‐keto‐PGFla and T × B2 increases were related to the severity of the disease. There was no relationship between 6‐keto‐PGF1α × B2 in PF, and day of menstrual cycle. It is suggested that endometriotic tissue and peritoneal macrophages may contribute to these prostanoids in PF. The smooth muscle activities of PF prostacyclin and T × A2 may be involved in infertility by inter

ISSN:0001-6349    

DOI:10.3109/00016348409156975

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348409156976

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Abstract.Previous studies have demonstrated a hereditary tendency to develop endometriosis and the incidence of the disease varies in different ethnic groups. The genetic background to these differences has not been clearly explained. The present investigation was performed to seek a possible association between certain HLA antigens and endometriosis. One hundred patients were typed for HLA‐A, ‐B and ‐C, and of these 24 were also typed for HLA‐DR. No significant deviations from the antigen frequencies in a normal population were found. We conclude that the development of endometriosis does not seem to be associated with HLA‐A, ‐B, ‐C or

ISSN:0001-6349    

DOI:10.3109/00016348409156977

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348409156978

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016348409156979

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY