摘要:

Abstract.In a prospective randomized study spontaneous and oxytocin induced labor “for convenience” have been compared with respect to uterine activity, duration of labor, the condition of the fetus and the newborn infant. The study consists of 84 normal patients, of whom 43 were induced at full term by amniotomy and oxytocin infusion using the Cardiff Infusion System Mark II; 41 patients served as controls. No difference in maternal age, number of previous pregnancies and pelvic score one week before the day of delivery were found between the groups. The following parameters were calculated: duration of labor, uterine activity, amount of bleeding in the third stage of labor, number of early and late decelerations as well as number of episodes of bradycardia in the CTG‐recordings, birth weight, Apgar score one and five minutes post‐delivery and blood gases in mother and child 60 seconds after delivery. No significant differences between the two groups were found. It is concluded that there are no increased risks to mother or fetus compared to normal labor provided that there is cephalic presentation and normal pregnancy, careful selection with respect to the length of pregnancy and the condition of the cervix and that the Cardiff infusion system is used with intrauterine pressure recording and continuous fetal heart mon

ISSN:0001-6349    

DOI:10.3109/00016347909154610

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.Fetal systolic time intervals (FSTI) were derived from the externally recorded electrocardiogram and phonocardiogram in 74 women during late pregnancy. The FSTI of the first 43 patients were recorded as a control. In the others FSTI were registered before and after intravenous injection of atropine to the mother to increase the range of fetal heart rate. Two patients in the atropine group were excluded.Correlation was found between the duration of the heart cycle (R‐R interval) and the mechanical systole (S1‐S2interval) before and after atropine.The amplitude of the initial part of the first heart sound (S1a) increased after atropine, when postatropine tachycardia evidenced significant placental transfer of the drug.After atropine some fetuses showed initial bradycardia or bradycardia without following tachycardia. In such periods of bradycardia S1aamplitude was reduced.During the initial period of postatropine tachycardia short periods of constant R‐R interval combined with varying S1aamplitude and S1‐S2interval occurred. A close correlation was then present between S1aamplitude and S1‐S2interval.The time from electrical to mechanical start of ventricular systole was measured as the R‐S1interval; it did not vary with heart rate in the control group or in the atropine group before atropine was given. Atropine shortened the R‐S1interval; no correlation was found between shortening and tachycardia.It is concluded that in the fetus, changes of FSTI can be observed from the externally recorded electrocardiogram and phonocardiogram. Signs of peripheral circulatory change after atropine were not found.The changes observed after atropinization can be explained as a reduction of vagal tonic inhibition of cardiac chronotropism and inotropism. Atropine also may cause a decrease of mitr

ISSN:0001-6349    

DOI:10.3109/00016347909154611

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.The serum level of an estrogen‐inducible plasma protein was followed by a radioimmunoassay in groups of women during treatment with various estrogens. After an initial increase, the mean value for the serum concentration was stable. The plateau level after six months of treatment was taken as a parameter of estrogenic potency. Eleven different hormonal preparations were compared and an estrogen index was constructe

ISSN:0001-6349    

DOI:10.3109/00016347909154612

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.The renal clearance of amylase, expressed as a proportion of simultaneous creatinine clearance (Cam/‐Ccr), was determined in 131 women in various stages of pregnancy. No abnormal serum levels of amylase were found. A moderate but significant increase in Cam/Ccr occurred during the last 15 weeks of pregnancy. Possible causes for this change were investigated in smaller groups of subjects. No increase in rapidly cleared isoamylase could be detected. No modification in renal tubular handling of protein could be evidenced, as assessed by measurements of the renal clearance of β2microglobulin, expressed as a proportion of simultaneous creatinine clearance. An increased glomerular permeability to amylase probably accounts for elevated Cam/Ccr in pregnan

ISSN:0001-6349    

DOI:10.3109/00016347909154613

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.DNA and RNA assayed in the placentae of three groups of pregnant women: normal second trimester (16–28), normal third trimester (28 weeks up to term) and in preeclampsia. The protein level in the placentae of the three groups was also assayed.The proteins, DNA and RNA all decreased after 28 weeks and up to term in normal pregnancy.In pre‐eclampsia DNA and RNA showed a significant increase compared with cases of normal third trimester pregnancy. Whereas the proteins also showed an increased level, this was still less than its concentration during the second trimester of pregnancy.Protein/DNA and RNA/DNA ratios were calculated for the three groups. These ratios showed a gradual decrease during normal pregnancy from 16 weeks up to term, but with a sharper decrease in pre‐ecla

ISSN:0001-6349    

DOI:10.3109/00016347909154614

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.The purpose of this study was to demonstrate if decreased fertility could be shown in women whose previous pregnancy had been terminated by a legally induced abortion.In 7 270 pregnant women fertility was measured as the time elapsed from the couple started sexual intercourse without using contraception to the present pregnancy. This interval was called “the latent period” and fertility was defined as reduced if it was longer than one year.In women whose previous pregnancy had been terminated by legally induced abortion subsequent decreased fertility could not be shown when compared with women whose previous pregnancy had ended in a live birth, the frequency of a latent period longer than one year not differing between these groups.When induced abortion had been complicated by pelvic inflammatory disease the frequency of a latent period more than one year was found to be higher than in women without this complicat

ISSN:0001-6349    

DOI:10.3109/00016347909154615

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.Cell suspensions from nine human ovarian primary cancers, their metastases and ascitic cells were treatedin vitrowith amethopterin and melphalan. Effects were measured by incorporation of H3‐TdR or H3‐UdR into the cells. There was significant heterogeneity of cytostatic effects on cells from the three sources in a given patient. Ascitic cells did not represent a “mean” of the cancer cell clones. The implications of these findings should be considered if cytostaticin vitroprediction tests are used to guide cytostatic treatment of p

ISSN:0001-6349    

DOI:10.3109/00016347909154616

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.In twelve women, in whom labor was induced by oxytocin infusion, intra‐uterine pressure (IUP) was recorded by micro‐transducers, and simultaneously the diameter of the uterine cavity was estimated by means of ultrasound. Myometrial tension was calculated according to the law of Laplace. In the ten women who were delivered within eight hours after the start of induction, myometrial tension was clearly higher than in the two in whom induction failed. No technical problems were encountered during the registrations, which in some cases lasted for more than five hours. It is suggested that with the described technique, a more accurate determination of myometrial activity is possible than with the generally used methods for IUP recording. The technique might facilitate evaluation of drug effects on the uterus during labor, and improve the IUP‐part of intrapartum clinical mon

ISSN:0001-6349    

DOI:10.3109/00016347909154617

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.The method hysterometry has been designed for the study of the effect upon the uterine muscle of pharmacologically active agents. Hysterometry has earlier been used on the pregnant uterus and is now described for the non‐pregnant situation. The capacity of the technique is exemplified with results achieved in a study of the effect of prostaglandin synthetase inhibitors and β‐receptor stimulating agents during dysmenor

ISSN:0001-6349    

DOI:10.3109/00016347909154618

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.Quinacrine hydrochloride, mainly used as an antimalarial, has been used as a nontoxic chemosterilant in a transvaginal procedure in the human female. Clinical experiments indicate that Quinacrine acts as a powerful obstructive agent exclusively on the epithelium of the intramural portion of the tube without alterating the histology of the endometrium.The precise mechanism of Quinacrine's obstructive action on the mucosa of the uterotubal junction is unknown.Its possible mode of action is binding to epithelial DNA thus forming a clot of granulomatous tissue, as Quinacrine is known to form adhesions when used in the control of neoplastic effusions.Zinc is known to inhibit Quinacrine‐DNA binding. The human endometrium, rich in Zinc is unaffected by Quinacrine, whereas the tubal cornua, with little Zinc promote the obstruction by Quinacrine DNA bondage.The procedure is effective in 90 per cent of the cases with two instillations of Quinacrine. Further studies are essential to find agents that would potentiate the action of Quinacrine on the human Fallopian tube epitheliu

ISSN:0001-6349    

DOI:10.3109/00016347909154619

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY