摘要:

Abstract.Dyre Trolle was born in Copenhagen on 27th. Feb. 1914. He started to study medicine in 1932, and qualified as a doctor in 1939. He became a specialist in gynaecology in 1950 and in obstetrics in 1952. Dyre Trolle became associate professor in gynaecology and obstetrics at the University of Copenhagen in 1956, and professor at the same school in Feb. 1962.

ISSN:0001-6349    

DOI:10.3109/00016347409157183

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.In three centers in Copenhagen prenatal chromosome analysis has been carried out on 93 fetuses. Forty patients had earlier born a child with Down's syndrome. One had a 47, XY,+D trisomy fetus. Twenty were 40 years of age or more. Two fetuses in this group had 47, XY,+21 trisomy and one patient had a spontaneous abortion, which was found to have the same constitution. in four of five pregnancies with familial translocations the fetus was a translocation heterozygote. in five cases with relatives affected with Down's syndrome, in seven where the mother had earlier born a child with a chromosome anomaly not being +21 trisomy and in seven at risk of various inborn errors of metabolism, the fetuses were normal with regard to the chromosome constitution. Seven of nine cases, which were at risk of having an X‐linked disease, were males. Five of these were therepeutic aborted, one denied abortion and had an affected male child. One male fetus had a haemophilic father and the family did not want another carrier femal

ISSN:0001-6349    

DOI:10.3109/00016347409157184

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.Quantitative and qualitative data on alkaline phosphatase from 108 samples of amniotic fluid, and from maternal serum, cord serum, chorionic and amniotic membranes, placenta and meconium, are reported. a significant difference was observed between the amniotic enzymatic activity in early and late pregnancy. by exclusion fetal skin and urogenital tract are proposed to be the source of amniotic fluid alkaline phosphatase as the enzyme patterns obtained by starch‐gel electrophoresis and thermal inactivation of amniotic fluid enzyme are different from the corresponding patterns obtained from other source

ISSN:0001-6349    

DOI:10.3109/00016347409157185

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.The concentration of oestriol in the amniotic fluid during the last trimester of normal pregnancy was studied. by transabdominal amniocentesis in 98 pregnant women 144 samples of amniotic fluid were collected. Only women with uncomplicated pregnancies, giving birth to normal infants at term, were included. the results and conclusions were as follows:1)a calculation of mean levels and upper and lower 95 % probabiliy limits was done for each gestational week in the last trimester. 2) Based on this a smooth curve, indicating the normal concentration area of amniotic fluid oestriol, was drawn. 3) the amniotic fluid oestriol concentration showed little variation before the 33rd gestational week (mean 86‐145 μg/l). During the subsequent period the concentration increased to a mean between 559‐881 μg/l and a lower limit between 294 and 464 μg/l at term (38—<42 weeks).4)Between the amniotic fluid oestriol concentration and the urinary oestriol excretion there was a highly significant correlation. Likewise, serial analyses of amniotic fluid and urinary oestriol showed the same increasing tendency during gestation.5)Between the amniotic fluid oestriol concentration on the one hand and the infant's birth weight or sex or the weight of the placenta on the other hand there was no significant correlation.6)Our method is suitable for clinical use, and on the basis of the normal concentration area described we intend to judge the clinical significance of the amniotic fluid oestriol assay as a measure of foetal we

ISSN:0001-6349    

DOI:10.3109/00016347409157186

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.In the present study the amniotic fluid oestriol concentration was correlated to the condition of the foetus and newborn in pathological pregnancies and compared with the urinary excretion of oestriol. by transabdominal amniocentesis in 58 pregnant women 83 specimens of amniotic fluid were collected. Our method and normal concentration area has been described in a previous report. the results and conclusions were as follows:1)in pregnancies complicated byperinatal deathof the foetus or newborn the amniotic fluid oestriol levels were low. However, when the amniotic fluid was contaminated with meconium, the urinary oestriol assay reflected the condition of the foetus in a better way.2)in connexion withanencephaliaof a living foetus the amniotic fluid oestriol concentration was very low.3)Amniotic fluid oestriol assays reflectedperinatal morbiditysuch as asphyxia and respiratory distress of the newborn, remarkably well and better than urinary oestriol assays.4)Amniotic fluid oestriol assays predictedsigns of intrauterine malnutrition(»small for dates» and/or dysmaturitas of the newborn) just as well as urinary oestriol assays.5)Fourteen out of seventeen women with pregnancy complications such as preecclampsia or hypertension, but giving birth tohealthy infantspresented normal oestriol concentrations in amniotic fluid. in this group too there was a good correlation between the condition of the newborn and the concentration of oestriol in amniotic fluid as well as the urinary excretion of oestriol.—It seems reasonable to conclude that the amniotic fluid oestriol assay has its advantages in preference to urinary oestriol assay. However, it was our impression that the two assays were complementary to one another in a favourable way. Thus the findings of the present study speak in favour of a more widespread combined use of the two oestriol ass

ISSN:0001-6349    

DOI:10.3109/00016347409157187

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.Serial maternal serum α1‐fetoprotein (AFP) quantitations were carried out in legal induced first and second trimester abortions by both a double antibody radioimmunoassay (RIA) and by a simple radioimmunoelectrophoretical (RIEP) technique. in seven cases of first trimester abortions carried out by suction curettage a marked immediate increase in maternal AFP was found in four cases. No change was observed in the remaining three. in six cases of legal second trimester abortions induced by instillation of 20 per cent sodium chloride solution a marked increase in maternal serum AFP was found in all cases. the increased AFP concentration found in induced second trimester abortions took place before death of the fetus and reached a maximum value a few hours after delivery of the fetus. As expected a rapid fall in the serum concentration of HPL and progesterone is seen when suction curettage is used. However, by instillation of a 20 per cent sodium chloride solution only a slight initial decrease is found for both HPL and progestero

ISSN:0001-6349    

DOI:10.3109/00016347409157188

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.A hemagglutination‐inhibition reaction (HAIR) for semiquantitative determination of human placenta lactogen hormone (HPL) in serum or whole blood from pregnant women is presented.The lower level of HPL concentration in serum for a positiv reaction of the test was found to be 2,3 mg/liter, making it suitable for determinations after the 32nd week of pregnancy.A microtechnique for combined sampling and dilution of capillary blood makes the assay suitable as a screening procedure in places with limited laboratory facilitie

ISSN:0001-6349    

DOI:10.3109/00016347409157189

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.So far no information is available as to whether a relationship exists between the concentration on the maternal plasma oestrogens and the birth weight of the newborn and its sex. Using a gaschroma‐tographic method (5) the maternal plasma concentrations of oestriol, oestrone and 17β‐oestradiol were measured in normal pregnancies. From their values the regression line for each oestrogen was calculated in the individual case. the hormone value on the regression line corresponding to the 40th week of pregnancy is correlated to the birth weight and the sex of the infant. the series comprises 20 normal pregnant women delivering 20 normal infants with birth weights ranging between 2700‐4100 g. As far as oestriol is concerned the series include a further 10 pregnancies, where nine of the babies born were small for dates. the correlation between plasma oestriol and birth weight is not statistically significant (0.10>P>0.05). the relationship of plasma oestrone and 17β‐oestradiol to birth weight is far from being significantly correlated. Concerning the sex of the infants, the mean values of plasma oestriol and 17β‐oestradiol of 10 women with female fetuses do not differ from the mean values of 10 women with male fetuses. the mean value of plasma oestrone in the first group, however, is twice the value in the second group, yet the difference is not statistically significant (

ISSN:0001-6349    

DOI:10.3109/00016347409157190

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.An investigation has been carried out to assess the accuracy by which the diurnal urinary excretion of oestriol (dU‐oestriol) in pregnant women can be estimated from urine specimens collected in periods less than 24 hours. Night urines (9 h) are not recommended as a substitute for diurnal urines (24 h). Even correlation of the oestriol output from the night urines with the output of creatininium gives day by day variations which are significantly greater than the corresponding variations of the diurnal urines. in cases where the collection of a correct diurnal urine specimen (24 h) is difficult to obtain and it is important to get a quick answer it is recommended to use a single voided urine specimen and to calculate the diurnal excretion of oestriol by means of the creatininium outpu

ISSN:0001-6349    

DOI:10.3109/00016347409157191

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Abstract.A method is described by which it is possible to record the pressure and frequency of labour pains, and the action of the foetal heart, using a single miniature pressure transducer introduced between the amniotic membrane and the uterine wall.

ISSN:0001-6349    

DOI:10.3109/00016347409157192

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY