摘要:

A method for determining small rates and fluctuations of flow has been applied to the uterine secretions in non‐pregnant women, the secretions being labelled by added heat, 4·10−3cal·sec−1. Base line secretory rates during consecutive phases of the menstrual cycle were determined but the main advantage of the technique is the unique possibility of studying fluctuations in the rate of flow as a measure of uterine motility, without interference from foreign bodies in the uterine cavity. The responses of the non‐pregnant human uterus in vivo to intravenously injected synthetic oxytocin and to the deposition of fluid in the posterior fornix are

ISSN:0001-6349    

DOI:10.3109/00016347209156862

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Two series of cases of umbilical cord prolapse are submitted. One comprises 97 cases and the other 64. The total corrected mortality rate was 13.0% and 34.5% respectively, the mature corrected mortality rate 1.5% and 20.0%. The total mortality for breech presentations with prolapsed cord was 19.2% and 23.8% respectively. In cephalic presentations the mortality rate was 10.3% and 54.3% respectively. This difference in mortality is explained by a more active attitude in the department having the lower mortality, where the diagnosis was more often made by vaginal examination, the delivery was more rapid, and the use of Caesarean section more common.

ISSN:0001-6349    

DOI:10.3109/00016347209156863

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

With the ultimate purpose of evaluating the accuracy and specificity of the fluorescence of acridine orange stained cells or tissues as a sign of malignancy, this compound and its binding to stain receptors have been studied with biophysical methods. The present paper describes the identification of the lines in the proton magnetic resonance spectrum of acridine orange zinc trichloride. The ring proton lines are weak but the methyl line is strong and easy to record with a high ratio of the signal‐to‐background noise. The methyl line is composed of two superimposed parts, one narrow and one broad, with the same chemical shift. The reason why the methyl line is divided into components is, however, still unkn

ISSN:0001-6349    

DOI:10.3109/00016347209156864

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Oral contraceptive treatment with a low daily dose of Norethindrone did not lower the Antithrombin‐III level in serum. This was in contrast to what was found in subjects taking estrogen‐progestogen age

ISSN:0001-6349    

DOI:10.3109/00016347209156865

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

A series of 25 healthy women, 13 of whom had a tendency to diabetes, was studied for 5 consecutive menstrual cycles, with regard to the effect of a combined oral contraceptive containing O.S mg norgestrel and 0.05 mg ethinylestradiol (Eugynon®) on the carbohydrate metabolism. The following tests were performed on these women at midcycle in the cycle prior to, in the two cycles during, and in the second cycle after administration of the drug: Fasting blood sugar, i.v. glucose‐tolerance, fasting insulin and insulin response to i.v. glucose injection. The drug was administered daily from the fifth to twenty‐fifth day of cycles two and three. Thus each subject served as her own control.The statistical analysis of the results showed no alteration in the fasting blood sugar or difference between those with a diabetic tendency and those without. Glucose assimilation was significantly improved during the second cycle of administration and the follow‐up cycle, this was not dependent on the tendency to diabetes. The women with a tendency to diabetes had a significantly slower assimilation than those with no such tendency. However, this difference remained constant throughout the period under study. The results of the fasting insulin test remained unchanged during the investigation, no difference was seen between the two groups of women, those with the tendency to the disease and those without. The insulin response test showed slightly higher values during the two cycles of administration, this increase was significant, and was seen to occur in both groups. The women with a diabetic tendency had slightly higher values in the insulin response test than those of the women belonging to the other group, the difference was not significant except in the second cycle of drug

ISSN:0001-6349    

DOI:10.3109/00016347209156866

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The content of fibrinolytic enzymes in the vessel walls in the puerperium was determined histochemically in biopsy specimens of hand veins and the release of such enzymes into the blood stream was studied after stimulation by venous occlusion of the arms. The local response of the fibrinolytic activity in the blood to such venous occlusion, which is known to be decreased during pregnancy, was almost normal as early as two hours post parlum. The fibrinolytic activity in the vessel wall was found to be normal on the 2nd‐5th day post parlum. The early return of the fibrinolytic activity in the blood and in the vessel wall is probably due to loss of the influence of placental hormones and perhaps also to the loss of a placental inhibitor of fibrinolysi

ISSN:0001-6349    

DOI:10.3109/00016347209156867

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Using a new method for estimation of cystine aminopeptidase (CAP) activity in maternal serum, serial CAP determinations have been performed in 7 women during normal pregnancy, in 7 patients after delivery, in 10 patients with pre‐eclampsia, in 5 patients with suspected placental insufficiency and in 4 multiple pregnancies. The results were as follows.The enzyme activity decreased slowly after delivery. The half‐life of the enzyme in maternal blood was calculated as 3–6 days except in one patient where only 20% of the enzyme activity was lost within 4 days. The decrease of CAP activity in serum after intra‐uterine foetal death was also very slow. In patients with uncomplicated mild toxaemia of pregnancy the CAP values were in the normal range. In patients with severe pre‐eclampsia the results varied. In one patient with acute severe pre‐eclampsia and a threatening eclamptic attack the CAP values were high, and this might be explained by the presence of non‐specific aminopeptidase activity in serum. In preeclampsia with associated retardation of foetal growth the CAP values were rather low, with decreasing values prior to foetal death. In patients with pronounced placental insufficiency the CAP values were consistently low, whereas high figures were often found in multiple pregnancy.The observations indicate that determination of CAP in maternal serum might be a valuable parameter in judging the condition of the placenta. However, the significance of CAP assays in assessing placental function cannot be established until the method is compared with other placental function tests on the same clin

ISSN:0001-6349    

DOI:10.3109/00016347209156868

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Semen samples were examined from 51 fertile men, and from the male partners in 283 infertile marriages. In addition to routine analysis, they were tested for sperm penetration through ovulatory cervical mucus, using the method of Kremer with slight modifications. Comparison of the 2 groups in regard to semen properties showed statistically significant differences between the means for density, percentage of living, motile and abnormal spermatozoa, for motility degree, and for sperm penetration. No significant difference between the means was found for volume, content of fructose and acid phosphatase in the seminal plasma. In the entire series a moderate correlation was found between sperm penetration and percentage of motile spermatozoa, motility degree, density, percentage of living and percentage of abnormal spermatozoa. A low correlation was found between sperm penetration and volume, content of fructose or acid phosphatase in seminal plasma. The variance of sperm penetration due to regression of the other semen properties was only 43%. Sperm penetration had the highest discriminant function coefficient of the tested semen properties. Semen samples from fertile men had high penetration values although other semen properties were sometimes pathological. The sperm penetration test is a most valuable supplement to routine semen analysis for male fertility estimation.

ISSN:0001-6349    

DOI:10.3109/00016347209156869

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Investigation of 31 patients who developed amenorrhoea following the use of combined oral contraceptives for a period of 3 to 84 months revealed that 55% had a variable degree of oligomcnorrhoea prior to the treatment. It is therefore concluded that an antecedent menstrual dysfunction is a relative contra‐indication to treatment with combined oestrogen‐gestagen preparations, and that another form of contraception should be recommended in these cases.In 5 of the 31 patients the amenorrhoea was associated with galactorrhea. None of these patients had any signs of a hypothalamic or hypophyseal tumour, and no explanation can be given for this phenomenon.Eighteen patients were observed without any subsequent hormonal treatment, 9 patients were treated with clomiphene alone, 1 patient with clomiphene‐HCG, 4 patients with HMG‐HCG, and in 1 patient a bilateral ovarian resection was performed. These forms of treatment resulted in ovulation in 16 patients and pregnancy in 5 patients. On the basis of both the present and previous investigations the following lines of treatment are recommended. In patients with no sterility problem the management should be expectant, whereas hormonal treatment should be initialed in patients with infertility. Clomiphene either alone or combined with HCG is the treatment of choice in patients with a normal oestrogen level, but in patients with a low oestrogen level treatment with human gonadotropins is pr

ISSN:0001-6349    

DOI:10.3109/00016347209156870

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

A double blind randomized trial was made to ascertain the effect of tranexamic acid (AMCA) (Cyklo‐kapron®) on the postoperative blood loss after conization. The case material consisted of 50 women referred to the clinic because of dysplasia or non‐invasive cancer of the cervix. Five patients were excluded for various reasons. The treatment started in the evening of the day of operation and was continued for another 12 days, the dose being three tablets every 8 hours, corresponding to 4.5 g of tranexamic acid daily when the active drug was given. During the first 7 postoperative days, when the patients were in hospital, the blood losses were determined quantitatively. Prophylactic treatment with tranexamic acid reduced the postoperative blood loss as compared with the placebo group, the blood losses being 23 ± 3.2 ml and 79 ± 20.4 ml respectively. Sudden profuse bleeding postoperatively, requiring remedial measures, occurred in 7 patients, all in the placebo group. With the exception of 1 patient in the placebo group, who complained of nausea, no side effects were re

ISSN:0001-6349    

DOI:10.3109/00016347209156871

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY