ISSN:0001-6349    

DOI:10.3109/00016348109162176

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract.From 1969 to 1976, 101 patients with St. Ia‐IIb cervical carcinoma were treated with the Cathetron (C) and 84 patients with radium (R). Surgery was carried out on 56.4% of the patients in group C and 60.7% in group R two weeks after the intracavitary radiotherapy and 51.5% of the patients in group C and 45.2% in group R received external irradiation with or without an operation. There was no statistical fifference in the survival between the two treatment groups, the 5‐year crude survival rate being 81.6% for group C and 78.6% for group R and the 3‐year crude survival rates 85.1% and 83.3% respectively. Local recurrence of tumour was more frequent in group R (10.7%) than in group C (3.0%) (p=0.03). There were more early complications during or after the Cathetron (10.9%) than radium treatment (3.6%), without any statistical significance, however. No differences were found in operative difficulties or early postoperative morbidity between the two groups during or after radical operations after intracavitary radioth

ISSN:0001-6349    

DOI:10.3109/00016348109162177

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract.A study was made to compare the incidence, quality and aetiology of complications after low and high dose‐rate intracavitary radiotherapy for St. Ia‐IIb cervical carcinoma in 185 patients, of whom 84 were treated with radium (R) and 101 with afterloaded Co60(Cathetron, C), from 1969 to 1976. the frequency of surgery and external irradiation was similar in both groups. There were more (p=0.01) complications in group C (27.7%) than in group R (13.1%). However, when the single fractions in the Cathetron treatment were lowered from 10 Gy to 7.5 Gy each in 1972, the incidence of complications decreased from 42.4% to 20.6% (p=0.02) and the latter incidence was not statistically different from group R. Intestinal complications were more frequent than urological ones in both groups. Low weight was significantly (p<0.025) correlated with the development of complications and previous laparotomy (p=0.0001) with the development of fistulae in grou

ISSN:0001-6349    

DOI:10.3109/00016348109162178

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract.From 1970 to 1976, 91 patients with St. I‐II endometrial carcinoma associated with a small uterine cavity (≤9 cm) were treated with the Cathetron (C) and 125 with radium (R). Surgery was carried out on 59.3% of the patients in group C and 80.0% in group R two weeks after the intracavitary radiotherapy and 56.0% of the patients in group C and 39.2% in group R received external irradiation with or without an operation. There was no statistical difference in the survival between the two treatment groups, the 5‐year crude survival being 79.4% for group C and 82.4% for group R, and the 3‐year crude survival rates 82.4% and 88.0% respectively. There was no statistically significant difference in the local recurrence of tumour between group C (3.3%) and R (0%); nor were the rates of early complications different, 3.3% in group C against 4.0% in group R. No differences were found in operative difficulties or early postoperative morbidity between the two groups during or after hysterectomies and bilateral salping‐ooophorectomies after intracavitary rad

ISSN:0001-6349    

DOI:10.3109/00016348109162179

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract.Complications after low and high dose‐rate intracavitary radiotherapy for St. I‐II endometrial carcinoma associated with a small (≤9 cm) uterine cavity were analysed, and comparisons of their incidence, quality and aetiology were made. the material comprised 216 patients treated from 1970 to 1976, of whom 125 were treated with radium (R) and 91 with afterloaded Co60(Cathetron, C). No significant difference was found in the incidence of complications between group C (14.3%) and group R (8.0%). When the single fractions in the Cathetron treatment were lowered from 10 Gy to 7.5 Gy each in 1972, the incidence of complications decreased significantly (p= 0.04) from 33.3% to 11.4%. Intestinal complications occurred more frequently than urological ones both in group C and R. Vascular disease was significantly (p=0.03) correlated with the development of complications in group R, while age, weight or previous laparotomies were not correlated with complications in either

ISSN:0001-6349    

DOI:10.3109/00016348109162180

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract.TDF (time‐dose factor values for both low (radium) and high dose‐rate (Co60, Cathetron) intracavitary regimes in the treatment of cervical and endometrial carcinoma were calculated. Although some statistical differences were found between the TDF values of patients with and without complications, individualization of the treatment is of utmost importance in preventing radiation‐induced complications. Patients treated by the Cathetron with single fractions of 10 Gy each had statistically more complications and higher TDF values than patients treated with fractions of 7.5 Gy each. Optimum TDF values for low and high dose‐rate treatments are given although it is shown that the TDF system overestimates the required dose at high dose‐rate by approximately 33%. Therefore a new normalizing constant of 1.18, instead of 1.57 as used so far, is

ISSN:0001-6349    

DOI:10.3109/00016348109162181

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY