摘要:

Abstract.This study presents four cases of fetal softtissue malformations diagnosed during pregnancy by ultrasonic scanning and amniography. The series comprises two fetal teratomas, one case of fetal ascites, and one case of a partial mole with coexistent fetus. Diagnostic and differential diagnostic problems are illustrated by a fifth case where the final diagnosis was a big maternal ovarian cyst‐adenoma coexistent with a normal fetu

ISSN:0001-6349    

DOI:10.3109/00016347609156912

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Estimations of serum HCT, HTSH, T4, T3, PBI, ETR, Triosorb, TBG‐binding capacity, BMR and urinary total estrogen were made simultaneously in 160 women in normal pregnancy. TRH stimulation tests were made in 20 cases in each trimester of pregnancy. HCT was detectable even in early pregnancy, tending to increase gradually toward the terminal stage of pregnancy as serum thyrotrophin bioactivity showed. On the other hand, serum TSH level measured by radio‐immunoassay remained essentially the same throughout the course of pregnancy as in the nonpregnant state, moreover, it was suggested by the TRH stimulation test that pituitary TSH secreting function of pregnant women was similar to that of the non‐pregnant. These findings suggest that thyroid hyperfunction during pregnancy which is shown by progressively increased T3, T4, and PBI may not be due to high estrogen‐high TBG binding capacity‐low free thyroxinenegative feed back‐high TSH secretion but to HCT originating from placenta. In spite of thyroid hormone increase, it is true that the clinical picture of hyperthyroidism is not manifest among normal pregnant women, and ETR remained within the non‐pregnant range throughout the course of pregnancy. We have also demonstrated that Triosorb decreased progressively. This may be interpreted to be due to the increase of TBG binding capacity which is increased progressively and binds more of free thyroxine during pregnancy. Such a change in TBG binding capacity is well known to be caused by the effect of estrogen which is progressively increased during pregnancy. In a word, it is possible to say that there is a placento‐thyroidal system in pregnancy; HCT elevates thyroid function and TBG increased by estrogen carries thyroid hormone

ISSN:0001-6349    

DOI:10.3109/00016347609156913

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.This is a study of heat‐stable alkaline phosphatase (HSAP65°C) concentrations in the serum of pregnant women with hypertension (42 cases), mild preeclampsia (40 cases) and severe pre‐eclampsia (22 cases). The results are seen in relationship to the occurrence of intrauterine fetal death, growth retardation, intrauterine and neonatal asphyxia as well as the respiratory distress syndrome (RDS) in the newborn. The importance of a precise clinical classification of the patients is stressed. Pathological HSAP values are those which lie either over or under the normal range for HSAP activity. In addition “zig‐zag” curves with values within the normal range are characterized as abnormal. Thus, serial estimations give the most reliable results. Serial estimations of HSAP are especially valuable in severe pre‐eclampsia. Abnormal HSAP values in the 28th–38th week of pregnancy are a serious prognostic sign. False abnormal HSAP results were found in all 3 patient groups. One possible false normal HSAP curve

ISSN:0001-6349    

DOI:10.3109/00016347609156914

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The serum lipid values at different stages of pregnancy in twenty‐six pregnant diabetic women attending a special antenatal clinic at the Department of Obstetrics and Gynecology, were compared with the corresponding values in four control series composed of non‐diabetic pregnant women. Control series were studied at weeks 10, 22, 34 and after delivery, respectively. Serum triglycerides were higher in the diabetic women at week 10 (p>0.01), week 34 (p>0.05) and after delivery (p>0.05). Furthermore, in the diabetic women, infant birth weights were correlated (r=0.52,p=0.05) with maternal serum triglyceride values at week 31. Women with the highest serum triglyceride values (0.001) in mothers with intra‐uterine deaths. Elevated plasma free fatty acids (FFA) in the diabetic mother would be a possible cause for elevated serum triglycerides through increased liver triglyceride synthesis, while in the fetus an excess of plasma FFA (passing through the placental barrier) together with normal or elevated plasma insulin would be a likely explanation for increased triglyceride synthesis in adipose tissue and thereby of increased fat depots and body

ISSN:0001-6349    

DOI:10.3109/00016347609156915

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.With the use of a technique, which permits the study of fibrinolytic enzymes and inhibitors in organ culture, human decidua was found to produce inhibitors capable of inhibiting plasminogen activation induced by urokinase as well as activators released from kidney explants. Also the medium in which rat and human decidua had been cultured was found to inhibit fibrinolytic activity of the rat ovum. The inhibitors emanating from the decidua are presumably of importance for facilitating the implantation of ova.

ISSN:0001-6349    

DOI:10.3109/00016347609156916

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Results from a prospective study in Malmö performed in 1963–65 are used to discuss the possible role of hormonal drugs in human fetal maldevelopment. Appr. 2 per cent of all women that had a child born were treated with gestagens during early pregnancy and slightly more had used Primodos as a pregnancy test. No harmful effect on embryonic development can be demonstrat

ISSN:0001-6349    

DOI:10.3109/00016347609156917

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Amniotic fluid phospholipid concentrations measured in 104 samples from 65 diabetic patients have been related to gestational age, the state of diabetes according to White's classification, and the development of the respiratory distress syndrome (RDS). There is statistically significant evidence of accelerated surfactant production in White classes D, F, from 34 to 37 weeks gestation. Classes A, B, C, have phospholipid concentrations not significantly different from a reference series. RDS occurred in 26% and was frequently associated with mature phospholipid concentrations. There was a significant correlation between low Apgar scores and subsequent development of RDS.

ISSN:0001-6349    

DOI:10.3109/00016347609156918

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Eighty‐seven cases of secondary amenorrhoea of more than 6 months' duration developing after treatment with oral contraceptives (group I) were compared with 227 cases of secondary amenorrhoea not preceded by treatment with combined tablets (group II). The two groups were collected during the same period. The average age of the patients was 4 years higher in group I than in group II. Oligomenorrhoea had previously occurred in 30% of group I and in 46% of group II. Pronounced predisposing factors, such as psychogenic trauma and stress with or without considerable change in body weight, were encountered in 26% in group I and 56% in group II. The incidence of increased urinary output of 17‐keto steroids, 17‐ketogenic steroids and of hirsutism was slightly higher in group II. The percentage of eosinophilic cells in vaginal scrapings was low in 20% in group I as compared with 46% in group II. Spontaneous return of pituitary‐ovarian function occurred in 40% in both groups. Patients recovering spontaneously in group I presented a maximum during the first few months, followed by a steady and fairly uniform decline. Spontaneous recovery in group II was more or less independent of time. It seems reasonable to believe that oral contraceptives did promote or contribute to the development of secondary amenorrhoea in about 50%, representing cases with various predisposing factors. A causal relation between oral contraceptives and secondary amenorrhoea was indicated in the remaining 50% because of perfectly normal ovarian function before treatment and absence of predisposing

ISSN:0001-6349    

DOI:10.3109/00016347609156919

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The concentrations of progesterone, estrogens, luteinizing hormone and follicle stimulating hormone were measured in samples of plasma taken frequently during normal menstrual cycles in fourteen Chinese women. Each of the menstrual cycles was characterized by hormonal changes which were comparable to those previously reported in Caucasian subjects.

ISSN:0001-6349    

DOI:10.3109/00016347609156920

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Amniotic fluid samples were collected aseptically from 29 normal pregnancies, between the 38th and 41st week of gestation and checked for sterility in the laboratory, in order to investigate in vitro the effect of the liquor on the growth of E. coli. Brain Heart Infusion (B.H.I.) and Ringer solution were used as controls. E. coli cultures were inoculated in amniotic fluid, B.H.I., Ringer solution and amniotic fluid plus B.H.I. and incubated at 37°C for 48 hours. At 0, 1, 3, 6, 12, 24, 36 and 48 hours of incubation, surface viable counts were performed to estimate the number of E. coli viable cells. The growth of E. coli in B.H.I. started during the 1st hour after inoculation and continued over 48 hours; in Ringer solution the mean growth curve was almost identical to that of B.H.I. In amniotic fluid the growth of E. coli began from the 1st hour of inoculation but the growth curve was much lower, became static in 24 hours and a permanent inhibition was observed thereafter. The addition of a small amount of B.H.I. in amniotic fluid enhanced the growth of E. coli, but the growth curve was lower in comparison to the curves of the two controls studied. In conclusion, after 48 hours of inoculation in amniotic fluid, 26 of the 29 cases showed bacteriostatic or bactericidal activity of the liquor upon the growth of E. coli

ISSN:0001-6349    

DOI:10.3109/00016347609156921

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY