摘要:

The results of various forms of primary treatment of cancer of the vulva during the decade 1958‐1968 in the Radium Centre, Århus Municipal Hospital, University of Århus, are submitted. The series consists of 67 patients classified by the T‐N‐M system (U.I.C.C. 1967). Comparison of 29 patients treated by vulvectomy and node dissection with 26 patients treated by less extensive surgery without node dissection showed a 19% higher corrected 4 year survival and a 14% lower nodal recurrence rate in the former group although according to the T‐N‐M classification it must be presumed to have contained rather more advanced cancers. There was quite a marked difference between the clinical assessment of the regional lymph nodes and the histological findings at dissection. This applied to the histologically positive as well as negative lymph nodes. A review of the literature shows that the present results are in keeping with previous publications which have shown that the treatment of choice in cancer of the vulva is still total vulvectomy with routine dissection of the superficial and deep inguinal lymph nodes, supplemented by dissection of the iliac lymph nodes, if histological examination during the operation shows positive lymph nodes in the ingu

ISSN:0001-6349    

DOI:10.3109/00016347209154003

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

During the years 1957‐1966 nineteen patients with advanced carcinoma of the vulva were selected for external radiotherapy using cobalt‐60 irradiation. All patients belonged to clinical stage T4, according to UICC proposed TNM‐classification of carcinoma of the vulva in 1967. No other treatment could be given in these advanced cases. Biopsies were taken and thin‐needle aspiration biopsies were performed from suspicious inguinal nodes. The local tumour dose was in the range 5 200 rad in 37 days to 6 900 rad in 45 days. The inguinal regions were irradiated in 11 of the 19 patients. Four of the 19 patients have a symptom‐free survival time of more than 5 years. Six patients had cytologically verified lymph node metastases in one or both groins; two of these patients have no signs of tumour growth in the inguinal regions after over 6 years. We recommend the use of super‐voltage treatment for patients with advanced tumours in the vu

ISSN:0001-6349    

DOI:10.3109/00016347209154004

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

An assay technique is described which permits the estimation of nanogram amounts of progesterone in tissues. After primary extraction of the tissue homogenate, the extract is purified by means of thin layer and column chromatography. Progesterone is then measured by competitive protein binding. With this technique it is possible to determine the amount of progesterone in less than 1 gram of myometrial or endometrial tissue.

ISSN:0001-6349    

DOI:10.3109/00016347209154005

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The histological changes in the placenta after intra‐amniotic injection of hypertonic saline for induction of abortion were compared with those after extra‐amniotic injection. In both groups a thin zone of necrotic villi was found immediately beneath the membranes. The necrotic zone was sharply demarcated from the underlying villi, which were microscopically intact. The decidual cells underneath Nitabuch's membrane showed extensive degenerative alterations. It is suggested that decidual changes rather than damage to trophoblast play a role in the induction of abortion. The mechanism by which these changes may lead to abortion is discus

ISSN:0001-6349    

DOI:10.3109/00016347209154006

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

A technique for dynamic studies of the mechanics of the uterine musculature in vivo is described, based on the registration of pressure responses to sinusoidally imposed changes in volume. The final amplitudes are varied between 1 and 9 ml and the frequency of volume changes is selected between 0.005 and 0.1 Hz. Having defined the frequency of the spontaneous activity of the uterus, end pressure, area of hysteresis and distance between the limbs of the loop are used as parameters to characterize the mechanical properties of the myometrium. The potential of the method includes the study of the effect upon the myometrium of pharmacologic agents with oxytocic and relaxant effects.

ISSN:0001-6349    

DOI:10.3109/00016347209154007

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The absorption of radio frequency energy emitted by a small intrauterine coil has been used for intrauterine scanning in order to localize intrauterine pathology, especially cancer. In order to improve the method the distribution of RF field intensities around coils of different geometries has been measured. Ringshaped coils have longer axial effective fields than other coil geometries, probably allowing diagnosis of more deeply lying processes. Still deeper processes may be reached by two‐coil systems of special design. The RF absorption has been shown to follow the squared value of RF field intensit

ISSN:0001-6349    

DOI:10.3109/00016347209154008

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Legal abortion by means of vacuum aspiration has been carried out in 78 primigravid women. The amount of blood lost per operation has been estimated. The mean hemoglobin loss during aspiration was 18.6 g. In the 35 cases where the hemoglobin percentage of peripheral blood had been determined before operation the total blood loss during the aspiration was calculated to 175 ml. There was a significantly higher hemoglobin loss at an aspiration in the 11th week of gestation than in the 10th week. No difference was found between operations in the 12th and 13th week. As a result of the above findings, which indicate only a small risk of major blood loss, we suggest that vacuum aspiration in primigravid women might be performed as an out‐patient procedure before the 11th week of gestation. In weeks 11‐13 the patients should be admitted to hospital but the operation still has more advantages than extra‐ or intra‐amniotic NaCl‐injections, at least in the hands of an experience

ISSN:0001-6349    

DOI:10.3109/00016347209154009

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Ureteric dilatation was established by intravenous pyelography in the early puerperium in 78% of the 41 patients and 4‐6 months post partum in 32% of the 18 patients examined. The change occurred in the early puerperium in 90% of the patients after a normal and in 67% after a preeclamptic pregnancy. The statistically almost significant difference was attributed in preeclampsia to the reducing effect it exerts on uterine circulation. Dilatation was more common on the right than on the left side.Pre‐eclampsia or dilatation of the upper urinary channels did not affect the ratio of the roentgenologic area of the renal pelves and the kidneys.The length of the kidneys for the group examined 4‐6 months post partum was 0.7 cm shorter on the right and 0.7‐0.9 cm shorter on the left side than for the patients investigated in the early puerperium.Ureteric compression caused by venous dilatation from the intensified uterine blood flow during pregnancy was considered to have an important role in the etiology of ureteric dilatation in pr

ISSN:0001-6349    

DOI:10.3109/00016347209154010

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Three cases in which pregnancy occurred in a non‐communicating rudimentary uterine horn are reported. Prior to operation in two of the cases a false diagnosis of ovarian cyst complicating the pregnancy was made. In the third case an uncomplicated missed abortion was assumed at first, but with the experience of the first two reported cases the correct diagnosis was made pre‐operatively. The functioning of the rudimentary horn before the pregnancy and the migration of the sperm, and the transport and nidation of the fertilized ovum are discus

ISSN:0001-6349    

DOI:10.3109/00016347209154011

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Serum ceruloplasmin, α1‐antitrypsin, α2‐macro‐globulin and the iron and T3binding proteins were studied in six women during abortion induced by hypertonic saline. After correction of the results for total serum protein changes (15%), no significant variations in the concentrations of the proteins studied could be observed within 48 hours following saline treatment. The insensibility of specific serum proteins as indicators of the welfare of the fetoplacental unit is di

ISSN:0001-6349    

DOI:10.3109/00016347209154012

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY