ISSN:0001-6349    

DOI:10.3109/00016347709156334

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016347709156335

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016347709156336

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.Peripheral plasma from four postmenopausal women was analysed for oestrone (E1) and oestradiol (E2) during 48 hours after oral intake of a single tablet of 2 mg Progynon®(oestradiol valerianate). Plasma levels of E1, E2and d‐norgestrel were analysed daily in five postmenopausal women during treatment with tablet Cyclabil®(oestradiol valerianate in a biphasic preparation with dl‐norgestrel) in 21 days. Radioimmunoassay (RIA) was utilized for the quantifications. Pretreatment plasma levels of E1were about 20 pg/ml and E2about 12 pg/ml. It is concluded that oestradiol valerianate is rapidly absorbed from the gastrointestinal tract and converted to E1. This is reflected by plasma levels of E1considerably higher than those of E2. The E2levels found were in the range of those in ovulatory women, while the oestrone levels were h

ISSN:0001-6349    

DOI:10.3109/00016347709156337

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.The bioavailability of 17 ß‐estradiol valerate, free 17 ß‐estradiol and Premarin was studied in 24 subjects suffering from secondary amenorrhea. 17 ß‐estradiol and estrone were determined by specific radioimmunoassay systems. All estrogens were administered as single oraldoses. Theamounts applied were 2 and 10 mg of 17 ß‐estradiol valerate or equivalent amounts of the free estradiol and Premarin, respectively. No elevations of 17ß‐estradiol serum levels were recorded at the lower dosages, whereas the increases of estrone serum levels were approximately tenfold over basal levels. Similar data were recorded in a group of 3 women with normal cycles after the ingestion of 2 mg of 17ß‐estradiol valerate. All subjects responded to the higher doses of estrogens with a moderate increase of 17ß‐estradiol serum levels, but with much higher elevation of estrone levels. These data suggest a rapid conversion of 17ß‐estradiol into estrone. The biological activity of 2 mg 17ß‐estradiol valerate is discussed on grounds of a possible metabolism of estrone sul

ISSN:0001-6349    

DOI:10.3109/00016347709156338

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.The effects of a 2‐phase preparation on the parameters of cycle function were studied in 14 normally menstruating women. The preparation, Cyclabil®, administered in a series of 11 tablets with 2.0 mg oestradiol valerate and 10 tablets with 2.0 mg oestradiol valerate in combination with 0.5 mg D,L‐norgestrel. The cervical function, the spinnbarkeit of the cervical mucus and its crystallisability and, by means of RIA, FSH, LH, 17ß‐oestradiol and the progesterone serum levels were determined continuously in a control cycle before the treatment, in the first and third treatment cycles and in a subsequent control cycle. The results show that no impairment of the normal cycle function were found during cyclical administration of the 2‐phase preparation in 13 women. Two pregnancies occurred during the therapy. The process of ovulation was inhibited in one subject during the medication.20 other women with pronounced premenopausal deficiency symptoms and cycle irregularities were treated with the 2‐phase preparation for 6 months. Apart from the good cycle regulation. the deficiency symptoms were eliminated completely in 19 women and almost completely in I woman. Checks of the FSH, LH, 17ß‐oestradiol and oestrone serum levels conducted at random during a medication cycle showed only a slight influence on the gonadotropin level. During the medication, E2can be demonstrated in comparison to E1at a

ISSN:0001-6349    

DOI:10.3109/00016347709156339

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016347709156340

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.In 6 groups of peri‐and post‐menopausal women, there was an inverse relation between the urinary sediment smear maturation value and the fasting urinary hydroxyproline/creatinine ratio. Administration of ethinyloestradiol and Progynova both reduced urinary hydroxyproline into the pre‐menopausal range, the fail being proportional to the starting value. Oestrogen therapy also produced a significant fail in plasma ionised calcium. In a prospective trial, oestrogen therapy prevented post‐menopausal bone loss but calcium therapy was less effective. It is suggested that a high fasting urinary hydroxyproline/creatinine ratio might be taken as an indication for oestrogen therapy in post‐menopausal women. In established post‐menopausal osteoporosis, pre‐disposing risk factors appear to be low calcium intake, malabsorption of calcium and low oestrogen status. These patients appear to represent the fast bone‐losers in the postmenopausal population. The accelerated bone loss can be wholly or partially corrected by hormone replacement therapy and by calcium supplements given to those with normal absorption only. These therapies also prevent loss of height due to further crush fractures. The malabsorption of calcium is very resistant to vitamin D therapy but responds to α‐OHD3. Balance data suggest that the most effective therapy may be a combination of lα

ISSN:0001-6349    

DOI:10.3109/00016347709156341

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.Substitution treatment with a biphasic hormone combination (Cyclacur®) was administered to twenty women in menopause. Nine of these had undergone hysterectomy and/or ovarectomy. The experimental cycle consisted of a daily dose of 2 mg estradiol valerianate as estrogen for 11 days, the identical dose of estrogen plus 0,5 mg dl‐norgestrel as gestagen for 10 days, and a 7‐day medication‐free period. An initial placebo cycle was administered, followed by 7 experimental cycles and one final placebo cycle. Laboratory tests were carried out regularly. There were no significant changes during the investigation in serum lipids, blood sugar values, or serum enzyme tests used as parameters of hepatic function. Of the hematological parameters a moderate rise in hematocrit was observed. There was no change in serum protein‐boun

ISSN:0001-6349    

DOI:10.3109/00016347709156342

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016347709156343

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY