摘要:

Abstract.The urinary excretion of histamine and its metabolites, methylhistamine, methylimidazoleacetic acid and imidazoleacetic acid, was measured under standardized dietary conditions in 24 women with normal pregnancies and in eleven patients with toxaemia of pregnancy. in addition, histamine metabolism was studied in five healthy women at delivery and in four other healthy pregnant women during treatment with aminoguanidine, which is an inhibitor of diamino oxidase (histaminase). A slight increase in the urinary excretion of methylimidazoleacetic acid was observed in normal pregnancy as well as in toxaemia of pregnancy compared to non‐pregnant women. in two toxaemic patients and in one of the healthy subjects the urinary excretion of unmetabolized histamine was moderately increased. Despite the very high diamino oxidase activity in the plasma and in the uterus during pregnancy, there were no signs of altered catabolism of endogenous histamine in the pregnant women. Smoking increased the urinary excretion of the quantitatively dominant histamine metabolite, methylimidazoleacetic acid, in pregnant subjects as it also does in nonpregnant subjects. the necessity of standardized dietary conditions in the study of histamine metabolism in man was again emphasize

ISSN:0001-6349    

DOI:10.3109/00016347709158346

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.In 76 women with spontaneous labour or labour induced with oxytocin or PGF2a, intra‐uterine pressure was recorded during the first stage of labour. A statistical analysis was performed of the intensity and frequency of contractions, the total uterine activity and the variability of peak‐to‐peak intervals and amplitudes of contractions. the duration of the latent phase was shortened by 50% in induced labour compared with spontaneous, while the active phase was less affected. However, the intensity and frequency of contractions and the uterine activity in Montevideo Units were of the same magnitude in spontaneous as in induced labour, apart from two cases of hyperactivity found in the induction groups. the variability of intervals between contractions and amplitudes of contractions were also of the same degree in all groups and no overall tendency towards greater regularity was seen during progress of labour. If irregular intervals between contractions were noted, when active cervical dilatation had begun, the progress of labour was slower and more uterine work was needed for dilatation than when the uterine activity was more re

ISSN:0001-6349    

DOI:10.3109/00016347709158347

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.The basic levels of the pregnancy zone protein (PZ) were measured by a radio‐immunoassay, in 270 women of various age. All women were apparently healthy taking no drugs. Values were correlated to age, parity, gonadotropins and estrogens. A significant age dependent increase was found for PZ while no influence could be attributed to the other factors studied. the present results emphasize that the age dependent variation of PZ concentration should be considered when clinical data of this protein are evaluate

ISSN:0001-6349    

DOI:10.3109/00016347709158348

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.A total of 244 pregnant women, 172 in the first and 72 in the third trimester, were screened for genital herpes simplex (HSV) and cytomegalovirus (CMV) infections using virus isolation, cytological examination and serological studies. in addition, immuno‐fluorescence staining of exfoliated cervical cells was used for the detection of HSV infections. Herpes simplex virus (HSV) could not be isolated and no characteristic HSV altered cells were found in cytological (PAPA) smears. Cytomegalovirus was isolated four times but PAPA smears obtained from these patients were also normal. in 34 (14%) patients HSV antiserum detected immunofluorescence positive exfoliated cervical cells. Overall, 14% of patients had HSV‐2 antibodies and 71% CMV antibodies. No differences between the first or third trimesters in these respects were no

ISSN:0001-6349    

DOI:10.3109/00016347709158349

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.During the years 1956–69, 74 cases of invasive cervical carcinoma treated by simple hysterectomy were referred to the Norwegian Radium Hospital. the 5 year survival for those with free operative borders was 77.1% as compared with 30.7% for those cases in which the tumour was transected during operation. Before operation for a supposed benign condition, cancer should always be ruled out. If simple hysterectomy is performed and cervical cancer found in the specimen, immediate postoperative megavoltage radiotherapy affords the best chance of cur

ISSN:0001-6349    

DOI:10.3109/00016347709158350

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.741 women suspected of placenta praevia were submitted to ultrasonic scanning during the second and/or third trimesters of pregnancy. in 61 an abnormal placental site was diagnosed. During Caesarean section, carried out in 46 of these cases, the location was compared with the ultrasound findings. the scanning diagnosis during the last trimester correlated with the findings at delivery. At scanning after the 35th week the diagnosis differed in only 4 cases. in all 4 there was a question of a low‐lying placenta versus partial placenta praevia. During the second trimester diagnoses of low‐lying placenta were revised in several cases at later scans. It is discussed whether these early diagnoses of an abnormal placental site, which later becomes normal, indicate a migrating placenta and/or an uncertainty of the scanning method. Early diagnosis of low‐lying placentae should be checked by repeat

ISSN:0001-6349    

DOI:10.3109/00016347709158351

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.Fifty‐six cervical smears originally classified as Pap. I, from women in whom cervical cancer of stage I to IV was detected within 4 to 5 years after the cytological check, were re‐examined in order to estimate the screening error and sampling failure. At the review, 35 smears were classified as Pap. II to V. the incidence of changed classification of the smears obtained from population screening was 70% and that of the smears taken at private specialists or at hospitals was about 50%. the influence of sampling failure on the evaluation of the smears classified as Pap. II should be considered. On 14 slides, correctly interpreted as negative, there were no columnar cells present, a fact that may indicate inefficient sampling of cells from the squamo‐columnar jun

ISSN:0001-6349    

DOI:10.3109/00016347709158352

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.The placenta was chosen as a possible model for evaluating the vascular injury and tissue injury provoked by tobacco smoking in the human body. Full term placentas from 4 smokers and 3 non‐smokers were studied in the transmission electron microscope. Pronounced changes were found in the group of smokers. the characteristic findings were broadening of the basement membrane of the placental villus, increase in collagen content of the villus, decrease in vascularisation and intimal changes in the villous capillaries and arterioles, with pronounced intimal oedema. Since similar changes have been reported previously from human umbilical arteries, and since these changes also can be induced in animal arteries by exposure to carbon monoxide or perfusion with nicotine, this study supports the concept that tobacco smoking is harmful to the human vascular system and tissue

ISSN:0001-6349    

DOI:10.3109/00016347709158353

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.Electrophysiological parameters were studied in 32 gynecological patients before and after major gynecological surgery. No changes in maximal nerve conduction velocity or simple reaction time could be found after either hysterectomy or ovariectomy. of the 20 ovariectomized patients, 3 developed subjective symptoms and electrophysiological signs of the carpal tunnel syndrome within a few months after surgery. Thus the carpal tunnel syndrome, which is common in women of menopausal age, seems to be precipitated also by iatrogenic menopause. the present findings indicate that ovarian relaxin overproduction cannot be the basis of the carpal tunnel syndrome, but they are consistent with the view that the syndrome is a sign of hypothalamic‐hypophyseal overactivity or imbalanc

ISSN:0001-6349    

DOI:10.3109/00016347709158354

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract.Ureteral peristalsis in five pregnant patients with signs of acute renal outflow obstruction was studied with the aid of a new technique for recording intraureteral pressure (ureterometry). with this technique it is possible to record the intraureteral pressure at three different levels in the ureter simultaneously. the rate of propagation and direction of the peristaltic waves can thus be determined. Retrograde peristalsis was found in three of the five patients and in one patient no peristaltic activity was present at all. the fifth patient demonstrated normal antegrade peristalsis. the findings at renography in the acute stage were in accordance with the ureterometric data.

ISSN:0001-6349    

DOI:10.3109/00016347709158355

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY