ISSN:0001-6349    

DOI:10.3109/00016349009013294

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016349009013295

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016349009013296

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

This study describes the association of a risk factor model for complicated delivery, perinatal morbidity and perinatal mortality with each of various types of delivery complications, types of perinatal morbidity and causes of perinatal mortality. The material comprises a total cohort, 4,066 pregnant women with singletons in a Danish county, and their newborn infants, of whom 494 (12%) had clinical morbidity during the first 5 days of life; 28 (0.7%) died perinatally. A set of 20 risk factors, identifiable before pregnancy, at any time during the pregnancy or at term, was devised by joining existing models for prediction of complicated delivery and of perinatal morbidity and mortality. Metabolic and disproportion‐related events were well predicted by the model, inertia‐related ones less so, and placental conditions not at all, except for abruption. All types of neonatal morbidity (except sepsis) were well predicted, as were deaths. The strongest predictors of perinatal death were signs of hydramnios (RR=16.1) and growth retardation (RR=7.2). The 20 risk factors affected 43% of the population, predicting 57% of the unfavorable perinatal eve

ISSN:0001-6349    

DOI:10.3109/00016349009013297

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

During a 4‐year period, 163 patients conceived after treatment of their infertility due solely to a female factor. They were divided into two groups, 108 patients treated medically (Group 1) and 55 treated surgically (Group 2). At the time of conception, the mean age in Group (1) was 24.9 ± 5.7 years while in Group (2) it was 31.2 + 6.1 years. The difference was statistically significant (p<0.01). The duration of infertility prior to pregnancy and the treatment‐to‐pregnancy interval were both significantly longer in Group (2) (p<0.05). The rates of miscarriage, multiple pregnancy, and preterm labor were higher in Group (1), though the differences were statistically not significant. In contrast, the rate of ectopic pregnancy was significantly higher in Group (2) (p<0.05), as was the need for elective cesarean section (p<0.01). Despite these differences, both groups had nearly the same perinatal o

ISSN:0001-6349    

DOI:10.3109/00016349009013298

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

To study the occurrence and significance of pregnancy‐associated hypertension and pre‐eclampsia in systemic lupus erythematosus (SLE), we studied retrospectively 34 pregnancies in 27 SLE patients in 1981‐87. Eleven pregnancies (32%) were hypertensive (group A). The remaining 18 patients during their 23 pregnancies had a normal blood pressure (group B). Previous nephritis was slightly more common in the hypertensive group (54.5% vs. 26.1%, NS). Preeclampsia was present in seven of the pregnancies (21%) and of whom four were superimposed. Flare‐ups of the disease were more common in the non‐hypertensive group (30.4%) than in group A (9.1%) (NS). Duration of pregnancy was the same in the two groups. Intra‐uterine growth retardation was present in 27.3% of the pregnancies in group A and in 13.0% of group B (NS). Fetal loss occurred only in 2 patients of the non‐hypertensive group; one patient had excacerbation of SLE and the other (with two stillbirths) high anticardiolipin antibodies. Our data suggest that pregnancy‐associated hypertension and pre‐eclampsia do not cause increased fetal loss in pregnancies affected by SLE. There seem to be other factors that are more important, such as antiphospholipid antibodies and flare

ISSN:0001-6349    

DOI:10.3109/00016349009013299

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Lysosomal cysteine proteinases (cathepsin H, B + L) and metallopro‐teinase (MMP7‐ase) activities were measured from early gestational period (6‐12 weeks) in frozen, non‐cultivated chorionic villi. The mean activity of cathepsin H was 50.99 mU/mg protein, of cathepsin B + L, 71.16 mU/mg protein, and of MMP7‐ase, 16.16 mU/mg protein. The MMP7‐ase enzyme activities showed a correlation with gestational age. There was a significant correlation between the activities of cathepsin H a

ISSN:0001-6349    

DOI:10.3109/00016349009013300

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The transfer of prostaglandin E2 (PGE2) across intact fetal membranes (amnion‐chorion‐decidua) obtained before and after the onset of labor was investigated using a novel system for in vitro fetal membrane culture. Studies using physiological concentrations of PGE2 showed that very little PGE2 will cross the membranes without being metabolised, before or after the onset of labor. It was only when pharmacological concentrations of PGE2 were used that the enzyme activity of the chorion was no longer able to prevent transfer of PGE2 without conversion to inactive metabolites. These results suggest that only small amounts of PGE2 from amnion are normally transferred across the chorio‐decidua before or after the onset of labor, but the metabolism of PGE2 subsequent to transfer across the fetal membranes requires further asses

ISSN:0001-6349    

DOI:10.3109/00016349009013301

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The effect of bacteria on the production of prostaglandin E2 (PGE2) and PGE2 metabolites by fetal membranes has been investigated. Live bacteria stimulated a large increase in the levels of PGE2 metabolites, but only a small increase in the levels of PGE2 on the fetal side of the membranes. No significant changes in the levels of PGE2 or its metabolites were found on the maternal side. Bacteria may therefore stimulate PGE2 production by fetal membranes during short‐term incubations, but it seems that the metabolic capacity of the chorion was so high that no change in PGE2 levels was detectable on the maternal side of the fetal membranes. This was confirmed by the finding that<1 % of3H‐PGE2 added to the fetal side of the membrane reached the maternal side without being metaboli

ISSN:0001-6349    

DOI:10.3109/00016349009013302

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The frequency of moderate and severe hot flushes was investigated in a group of women (n=142) who took part in organized physical exercise on a regular basis, and a control group of all women 52 and 54 years old in the city of Linkoping, Sweden (n = 1,246). Only women with natural menopause and without a history of hormonal replacement treatment were statistically compared in the study. It appeared that moderate and severe vegetative symptoms with hot flushes and sweatings were only half as common among the physically active postmenopausal women (21.5%) as in the control group (43.8%). Although this could be due to a positive selection of these physically active women, it might also be due to the fact that exercise may affect the mechanisms that elicit hot flushes in peri‐ and postmenopausal wome

ISSN:0001-6349    

DOI:10.3109/00016349009013303

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY