摘要:

Abstract.The methyl line of the proton magnetic resonance spectrum of acridine orange zinc trichloride, dissolved in heavy water, has been studied. This line consists of two overlapping components with different widths. A mathematical technique has been developed to resolve the two components quantitatively. Their relative proportion depends on the acid‐base state of the molecular environment. If the stain is adsorbed on albumin the narrow component quickly disappears, while adsorption on RNA gives rise to a broadening of the narrow line. With large amounts of albumin or RNA, both components disappear. DNA strongly adsorbs acridine orange with complete disappearance of all NMR spectral lines. Mitochondria, submitochondrial particles and microsomes cause some broadening of the narrow component of the methyl line. Due to the obvious alterations of the NMR spectrum, in the circumstances mentioned, this type of spectroscopy may be used for the biophysical characterization of interaction mechanisms between acridine orange and various proteins, nucleic acids and cell fraction

ISSN:0001-6349    

DOI:10.3109/00016347309158480

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Abstract.The seminal properties and female fertility factors were studied in 45 couples where homologous in‐ seminations were performed. For 10 couples (group I) normal coitus was impossible. In this group there were 8 normal pregnancies and 1 miscarriage. For 35 couples (group 11) the postcoital test showed persistently reduced penetration because of poor semen quality or hostility of the cervical mucus. In this group there were 10 concep tions, 4 normal pregnancies and 6 miscarriages. The semen quality was a more important prognostic than pathological findings in the women. In vitro sperm penetration of cervical mucus seemed to be the best criterion for judging the prognosis. Homologous insemination can be of value in the treatment of infertility, but careful selection of patients is neede

ISSN:0001-6349    

DOI:10.3109/00016347309158481

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Abstract.The intra‐uterine volume of 10 obstetrically normal nulliparous midtrimester patients was increased by the intra‐amniotic instillation of 350 ml Macrodex. There were 2 treatment failures due to the rupturing of the fetal membranes within 2 hours of the instillation. In all the remaining 8 patients the intra‐uterine pressure increased gradually, following volume increase. However, it only reached the magnitude demanded for clinical abortion

ISSN:0001-6349    

DOI:10.3109/00016347309158482

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Abstract.This investigation was carried out to determine whether paracervical block (PCB) has any effect on the duration of the first stage of labour, relating the speed of cervical dilatation to uterine activity. Uterine activity was measured by internal tocometry and calculated in Montevideo units (MU).Fourty patients were selected and allocated in random manner to a PCB or a control group, the patients in the latter receiving other kinds of analgesia. Oxytocin was given when required, to assure a steady and fairly high degree of uterine activity. Four patients were excluded.The mean duration of the first stage of labour, from cervical dilatation 2 to 10 cm, was 161 minutes in the PCB group, 237 minutes in the control group.Uterine activity, calculated as total MU needed for each cm of cervical dilatation, was reduced after PCB, the differences being statistically significant for increments from 3 to 8 cm cervical dilatation inclusive.PCB caused a transient reduction in frequency of contractions, and a relative fall in amniotic pressure between contractions.It is concluded that PCB facilitates cervical dilatation by inhibiting muscular contraction in the lower uterine segment.

ISSN:0001-6349    

DOI:10.3109/00016347309158483

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Abstract.The effects of an oral combined contraceptive (OC) (norethisterone + mestranol) on plasma levels of glucose, free fatty acids (FFA), glycerol, D‐β‐hydroxy‐ butyrate and triglycerides in 39 healthy women were followed. Plasma samples were collected before and during the end of the first and second cycles of OC administration. OC caused a significant increase in triglycerides while the levels of glucose, FFA, glycerol and β‐B‐ hydroxybutyrate were

ISSN:0001-6349    

DOI:10.3109/00016347309158484

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Abstract.In a previous study on diamine oxidase activity of amniotic fluid (4) it was questioned whether enzyme inhibition with an intramuscular injection of aminoguanidine sulphate was due to a passage of the inhibitor to the amniotic fluid or was secondary to enzyme inhibition in the maternal blood. In the present investigation amniotic fluid was sampled from 23 women in the second trimester of gestation. In 15 cases, aminoguanidine sulphate was given 1 hour before sampling. In 5 cases aminoguanidine sulphate was detected in the amniotic fluid by thin layer chromatography and a subsequent staining technique. In 10 cases the presence of a diamine oxidase inhibitor in the amniotic fluid was shown by observing the effect of this amniotic fluid on venous plasma with a high diamine oxidase activity. When aminoguanidine sulphate was not given, the amniotic fluid did not show such inhibitory effects. Nor did the incubation itself inhibit the enzyme.

ISSN:0001-6349    

DOI:10.3109/00016347309158485

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

ISSN:0001-6349    

DOI:10.3109/00016347309158486

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Abstract.17α‐hydroxyprogesterone caproate (Proluton Depot®, Schering AG, Berlin) was given after ovulation in a dose of 500 mg intramuscularly to four women with normal menstrual cycles. The plasma levels of progesterone and oestradiol were measured and compared to the levels found during previous control cycles of the same women. In the four normal women a small reduction of the plasma levels of progesterone and oestradiol was found after the injection of 500 mg of 17α‐hydroxyprogesterone caproate. However, the number of days with progesterone concentrations above the mean level of the follicular phase was not changed. The menstrual bleeding was delayed and appeared to be a withdrawal bleeding from 17α‐hydroxyprogesterone caproate rather than from prog

ISSN:0001-6349    

DOI:10.3109/00016347309158487

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Abstract.Electronic FHR‐monitoring is, like monitoring of the heart in adults, combined with artefacts. In the fetus interpretation of artefacts and diagnosis of cardiac disease are facilitated, if the filtered R‐wave is presented simultaneously with FHR. Changes in rate depending on artefacts can be misinterpreted with commercial instrumentations as depending on “fetal distress” which can be avoided with the equipment described in this paper. Filter properties and further reduction of noise are di

ISSN:0001-6349    

DOI:10.3109/00016347309158488

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Abstract.Maternal and fetal acid‐base changes in a series of 56 normal cases from Edmonton, Canada, are compared with a similar series from Lund, Sweden, published by Jacobson. During labour, pH in the mother and in the fetus falls in Lund, but not in Edmonton. The mothers labour hard in Lund and are more sedated in Edmonton. The pH difference (δpH) between the maternal and fetal blood is about 0.10 in both series.In another series of 61 cases classified as abnormal because of changes in fetal heart rate or meconium staining of the amniotic fluid, the mean δpH was 0.15. δpH was correlated to the fetal scalp pO2and oxygen saturation and there was a significant drop in fetal oxygenation when ≤pH increased.It is suggested that fetal preacidosis be redefined as δpH 0.15–0.19 and acidosis δpH≤0

ISSN:0001-6349    

DOI:10.3109/00016347309158489

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY