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11. |
Intraosseous vascular accessFrom the archives to the ABC |
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Critical Care Medicine,
Volume 27,
Issue 6,
1999,
Page 1053-1054
Desmond Bohn,
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ISSN:0090-3493
出版商:OVID
年代:1999
数据来源: OVID
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12. |
Bacterial peritonitisInnovative experimental treatment |
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Critical Care Medicine,
Volume 27,
Issue 6,
1999,
Page 1055-1056
Arthur P. Wheeler,
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ISSN:0090-3493
出版商:OVID
年代:1999
数据来源: OVID
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13. |
Divalent cations and bronchodilation in asthma |
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Critical Care Medicine,
Volume 27,
Issue 6,
1999,
Page 1056-1057
W. Michael Alberts,
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ISSN:0090-3493
出版商:OVID
年代:1999
数据来源: OVID
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14. |
The effect of 21-aminosteroids on endotoxin-induced TNF-alpha release |
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Critical Care Medicine,
Volume 27,
Issue 6,
1999,
Page 1058-1059
Robert E. Kimura,
David W. A. Beno,
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ISSN:0090-3493
出版商:OVID
年代:1999
数据来源: OVID
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15. |
NO good-or not? |
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Critical Care Medicine,
Volume 27,
Issue 6,
1999,
Page 1059-1060
Paul G. Smith,
Jeffrey Blumer,
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ISSN:0090-3493
出版商:OVID
年代:1999
数据来源: OVID
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16. |
Reversal of fortune? Respiratory failure after bone marrow transplantation |
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Critical Care Medicine,
Volume 27,
Issue 6,
1999,
Page 1061-1062
Thomas Bojko,
Daniel A. Notterman,
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ISSN:0090-3493
出版商:OVID
年代:1999
数据来源: OVID
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17. |
Nitric oxide production in neonatal and pediatric sepsis |
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Critical Care Medicine,
Volume 27,
Issue 6,
1999,
Page 1063-1065
Joseph A. Carcillo,
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ISSN:0090-3493
出版商:OVID
年代:1999
数据来源: OVID
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18. |
SCCM INAUGURATES TOLL-FREE PHONE ACCESS TO MEMBER SERVICE CENTER |
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Critical Care Medicine,
Volume 27,
Issue 6,
1999,
Page 1065-1065
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ISSN:0090-3493
出版商:OVID
年代:1999
数据来源: OVID
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19. |
Fluconazole prophylaxis prevents intra-abdominal candidiasis in high-risk surgical patients |
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Critical Care Medicine,
Volume 27,
Issue 6,
1999,
Page 1066-1072
Philippe,
Eggimann Patrick,
Francioli Jacques,
Bille Remy,
Schneider Mei-Miau,
Wu Germain,
Chapuis Rene,
Chiolero Andre,
Pannatier Julian,
Schilling Stefanos,
Geroulanos Michel P.,
Glauser Thierry,
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摘要:
ObjectiveTo evaluate the efficacy and safety of intravenous fluconazole for the prevention of intra-abdominal Candida infections in high-risk surgical patients.DesignRandomized, prospective, double-blind, placebo-controlled study.SettingTwo university-affiliated hospitals in Switzerland.PatientsForty-nine surgical patients with recurrent gastrointestinal perforations or anastomotic leakages.InterventionsProphylaxis with intravenous fluconazole (400 mg per day) or placebo continued until resolution of the underlying surgical condition.Measurements and Main ResultsPatients were evaluated daily, and specimens for culture were obtained three times per week during prophylaxis. The primary study end points were the frequency of and the time to intra-abdominal Candida infections. Secondary end points were the frequency of candidiasis (intraabdominal and extra-abdominal) and the emergence or persistence of Candida colonization. Among patients who were not colonized at study entry, Candida was isolated from surveillance cultures during prophylaxis in 15% of the patients in the fluconazole group and in 62% of the patients in the placebo group (relative risk, 0.25; 95% confidence interval, 0.07 to 0.96; p = .04). Candida peritonitis occurred in one of 23 patients (4%) who received fluconazole and in seven of 20 patients (35%) who received placebo (relative risk, 0.12; 95% confidence interval, 0.02 to 0.93; p = .02). In addition, one catheter-related Candida albicans sepsis occurred in a fluconazole-treated patient. Thus, overall, candidiasis developed in two fluconazole patients and seven placebo patients (relative risk, 0.25; 95% confidence interval, 0.06 to 1.06; p = .06). C. albicans accounted for 87% of the Candida species isolated before or during prophylaxis, and all C. albicans strains were susceptible to fluconazole. Fluconazole was well tolerated, and adverse events occurred at similar frequencies in both treatment groups.ConclusionsFluconazole prophylaxis prevents colonization and invasive intra-abdominal Candida infections in high-risk surgical patients. (Crit Care Med 1999; 27:1066-1072)
ISSN:0090-3493
出版商:OVID
年代:1999
数据来源: OVID
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20. |
ATTENTION |
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Critical Care Medicine,
Volume 27,
Issue 6,
1999,
Page 1072-1072
&NA;,
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ISSN:0090-3493
出版商:OVID
年代:1999
数据来源: OVID
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