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21. |
Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis |
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Critical Care Medicine,
Volume 24,
Issue 12,
1996,
Page 2059-2070
Richard D. Piper,
Deborah J. Cook,
Roger C. Bone,
William J. Sibbald,
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摘要:
ObjectivesTo discuss theoretical and practical aspects relating to the design of animal studies investigating the efficacy of novel therapeutic agents for the treatment of sepsis, and to make explicit the process whereby these studies can be evaluated for the purpose of designing clinical trials in humans.Data SourcesRelevant articles from the pertinent literature were reviewed.Study SelectionStudies relevant to an evidence-based assessment of clinical studies on therapeutic efficacy, and studies relevant to the design of animal models of sepsis were selected.Data ExtractionConcepts relevant to an evidence-based assessment of the animal literature were extracted.Data SynthesisArticles were reviewed and an evidence-based framework for the assessment of animal studies was developed. In this process, we discuss the steps that are necessary to assess the internal validity of an individual study and review topics relevant to the application of animal data to the design of clinical trials.ConclusionsThe success of clinical trials of sepsis therapies is predicated on the generation and interpretation of sound preclinical data. In this review, we have attempted to outline an evidence-based approach to the assessment of preclinical animal studies evaluating novel therapeutic interventions in sepsis. (Crit Care Med 1996; 24:2059-2070)
ISSN:0090-3493
出版商:OVID
年代:1996
数据来源: OVID
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22. |
Measuring the Total Expiratory Time Constant |
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Critical Care Medicine,
Volume 24,
Issue 12,
1996,
Page 2071-2072
Josef X. Brunner,
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ISSN:0090-3493
出版商:OVID
年代:1996
数据来源: OVID
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23. |
Treating Hypertensive Patients With Intracranial Pathology |
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Critical Care Medicine,
Volume 24,
Issue 12,
1996,
Page 2072-2073
Michael M. Hirschl,
Markus Mullner,
Michael Binder,
Anton N. Laggner,
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ISSN:0090-3493
出版商:OVID
年代:1996
数据来源: OVID
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24. |
Treating Hypertensive Patients With Intracranial Pathology |
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Critical Care Medicine,
Volume 24,
Issue 12,
1996,
Page 2073-2074
Jeffrey R. Kirsch,
Charisse S. Tietjen,
Patricia D. Hurn,
John A. Ulatowski,
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ISSN:0090-3493
出版商:OVID
年代:1996
数据来源: OVID
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25. |
Handbook of Clinical Automation, Robotics, and Optimization |
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Critical Care Medicine,
Volume 24,
Issue 12,
1996,
Page 2074-2075
Robert C. Rock,
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ISSN:0090-3493
出版商:OVID
年代:1996
数据来源: OVID
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26. |
History of the Disorders of Cardiac Rhythm |
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Critical Care Medicine,
Volume 24,
Issue 12,
1996,
Page 2075-2075
G. Thomas Evans,
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ISSN:0090-3493
出版商:OVID
年代:1996
数据来源: OVID
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