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31. |
EDITORIAL APPROACH |
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Critical Care Medicine,
Volume 26,
Issue 9,
1998,
Page 1586-1586
Joseph E.,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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32. |
Cost of extracorporeal life support in pediatric patients with acute respiratory failure |
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Critical Care Medicine,
Volume 26,
Issue 9,
1998,
Page 1587-1592
Atul,
Vats Robert,
Pettignano Steven,
Culler Jean,
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摘要:
ObjectivesTo determine the impact of extracorporeal life support (ECLS) on mortality in pediatric patients with acute hypoxemic respiratory failure (AHRF) at our institution; and to calculate the hospital charges associated with the use of ECLS.DesignRetrospective review of medical records and hospital charges.SettingPediatric intensive care unit (ICU) of a university-affiliated children's hospital.PatientsTwenty patients admitted to the pediatric ICU between 1991 and 1995 for AHRF who received ECLS as a part of their hospital course.InterventionsPredicted mortality was calculated using the Pediatric Respiratory Failure score and was compared with survival at the time of hospital discharge. Hospital charges were used as a proxy for resource utilization. Cost-per-life-year-saved calculations were performed based on a normal life expectancy for survivors.Measurements and Main ResultsTwenty patients were identified. The median age was 4.83 yrs. The median duration of ECLS was 9 days, with 19.5 days in the pediatric ICU and 23.5 days for the entire hospital length of stay. The observed mortality rate for these patients was 20%. Median predicted mortality rate based on the Pediatric Respiratory Failure score calculation was 83%. The hospital charges incurred by these patients was a median of $199,096. Based on a normal life expectancy for survivors, this results in a cost of $4,190/life-year.ConclusionsECLS for the pediatric patient with AHRF is done at a considerable cost. However, ECLS affects survival favorably, and compares favorably when considering cost/life-year calculations. The data presented in this study may serve as a benchmark for comparison with newer therapies (i.e., liquid ventilation, nitric oxide). These data also provide a framework for cost-based analyses at other ECLS institutions. (Crit Care Med 1998; 26:1587-1592)
ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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33. |
DESIGN AWARD FOR NEONATAL AND PEDIATRIC INTENSIVE CARE UNITS |
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Critical Care Medicine,
Volume 26,
Issue 9,
1998,
Page 1592-1592
&NA;,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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34. |
A report of the use of the Dynamic Objective Risk Assessment (DORA) score in the changing pediatric intensive care environment |
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Critical Care Medicine,
Volume 26,
Issue 9,
1998,
Page 1593-1595
Christopher M. B. Heard,
James E. Fletcher,
Michele C. Papo,
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摘要:
ObjectiveTo assess the clinical use of the Dynamic Objective Risk Assessment (DORA) severity of illness score in a site remote from its development.DesignProspective chart review.SettingTertiary referral pediatric intensive care unit (PICU).PatientsOne hundred sixty consecutive admissions Involving 621 patient days.InterventionsNone.Measurements and Main ResultsPediatric Risk of Mortality (PRISM) scores were collected daily for all PICU patient days. Collection of data was performed by a physician not directly involved in the ordering of vital signs or laboratory data. The daily DORA score was calculated from the previous day's PRISM score and the admission PRISM score according to a previously described formula. The DORA score determines the patient's risk of mortality for the next 24 hrs. Also documented were the tests not ordered for each patient day. The sensitivity and specificity of the DORA score in our patient population were very similar to that previously reported using the previously described 1% cutoff for predicted mortality. We also noted that the tests ordered were related to the physician's perception of the patient's degree of sickness, and were themselves predictive of outcome.ConclusionAn outcome scoring system created in one group of PICUs can be applied to patients in another PICU remote from where the scoring system was developed with similar ability to predict outcome. (Crit Care Med 1998; 26:1593-1595)
ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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35. |
Evaluation of Institutional Review Board review and informed consent in publications of human research in critical care medicine |
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Critical Care Medicine,
Volume 26,
Issue 9,
1998,
Page 1596-1602
Idit Matot,
Reuven Pizov,
Charles L. Sprung,
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摘要:
ObjectiveTo examine the frequency of obtaining Institutional Review Board (IRB) approval and informed consent in critical care research.Data Sources and Data ExtractionOne-year retrospective review of original critical care research in humans published in seven journals, including American Journal of Respiratory and Critical Care Medicine, Chest, Critical Care Medicine, Intensive Care Medicine, The Journal of the American Medical Association, Lancet, and The New England Journal of Medicine. Studies were examined for general information (country/state where the research was performed, affiliation of the hospital to a medical school, and whether the work was supported by a grant and specifically by a pharmaceutical company), approval by IRB, method of consent, design of research, and interventions involved in the study.Data SynthesisTwo hundred seventy-nine studies were reviewed, 124 (44%) of which were conducted in the United States. Two hundred forty-three (87%) studies were performed in a university institution, 96 (34%) studies were supported by a grant, and 23 (24%) studies were supported by a pharmaceutical company. In 66 (24%) studies, there was no evidence of IRB review and informed consent approval. IRB approval was obtained but the method of consent was not specified in 36 (13%) studies. No significant differences were found in obtaining IRB approval and informed consent between research conducted in the United States (n = 71, 57%) or outside the United States (n = 92, 59%). Grant support was obtained in ten (9%) of the 116 studies not fully approved, compared with 70 (50%) of the 140 studies that obtained full approval (p<.05). All studies (23) supported by the pharmaceutical industry were fully approved.ConclusionsMany published studies in critical care lack IRB approval and/or informed consent. All research supported by the pharmaceutical industry was fully approved. The findings raise ethical concerns about critical care research. (Crit Care Med 1998; 26:1596-1602)
ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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36. |
Understanding articles describing clinical prediction tools |
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Critical Care Medicine,
Volume 26,
Issue 9,
1998,
Page 1603-1612
Adrienne G. Randolph,
Gordon H. Guyatt,
James E. Calvin,
Gordon Doig,
W. Scott Richardson,
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摘要:
ObjectivesClinical prediction rules and models are developed by applying statistical techniques to find combinations of predictors that categorize a heterogeneous group of patients into subgroups of risk. Our goal is to teach clinicians how to evaluate the validity, results, and applicability of articles describing clinical prediction tools.Clinical ExampleAn article describing a rule to predict the need for intensive care unit care admission in patients presenting to the emergency room with chest pain.RecommendationsValid clinical prediction tools are developed by completely following up a representative group of patients, by evaluating all potential predictors and testing the independent contribution of each predictor variable, and by ensuring that the outcomes were independent of the predictors. To evaluate the results of an article describing a clinical prediction tool, clinicians need to know what the prediction tool is, how well it categorizes patients into different levels of risk, and what the confidence intervals are around the risk estimates. Valid prediction tools are not applicable in every patient population. Before patient care application, the clinician should ensure that the tool maintains its prediction power in a new sample of patients, that the patients are similar to patients used to test the tool, and that the tool has been shown to improve clinical decision-making.ConclusionsThere has been an increase in the development and validation of clinical prediction rules and models. It is important to evaluate the validity and reliability of these prediction tools before application. (Crit Care Med 1998; 26:1603-1612)
ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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37. |
Principles and Practice of Intensive Care Monitoring |
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Critical Care Medicine,
Volume 26,
Issue 9,
1998,
Page 1613-1614
Christopher W. Bryan-Brown,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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38. |
Cardiac Bioassist |
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Critical Care Medicine,
Volume 26,
Issue 9,
1998,
Page 1614-1614
Steven Edbril,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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