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| 1. |
Clinical trial networksA unique opportunity for critical care |
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Critical Care Medicine,
Volume 26,
Issue 4,
1998,
Page 625-626
James E. Calvin,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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| 2. |
Corticosteroids in septic shockResurrection of the last rites |
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Critical Care Medicine,
Volume 26,
Issue 4,
1998,
Page 627-630
Idit MD Matot,
Charles L. Sprung,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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| 3. |
Glucocorticoid treatment of sepsis and acute respiratory distress syndromeTime for a critical reappraisal |
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Critical Care Medicine,
Volume 26,
Issue 4,
1998,
Page 630-633
G. Umberto Meduri,
Siva Kanangat,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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| 4. |
Survivors, beware of posttraumatic stress disorderWhat shall we tell the Men in Black |
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Critical Care Medicine,
Volume 26,
Issue 4,
1998,
Page 634-635
David R. Coursin,
Douglas B. Coursin,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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| 5. |
Prophylactic granulocyte colony-stimulating factor in critically ill patientsNot time yet |
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Critical Care Medicine,
Volume 26,
Issue 4,
1998,
Page 636-637
Claire Esposito,
Steven M. Banks,
Peter Q. Eichacker,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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| 6. |
Inhibition of nitric oxide synthesis in sepsisA promising strategy |
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Critical Care Medicine,
Volume 26,
Issue 4,
1998,
Page 638-639
Steven M. Hollenberg,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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| 7. |
Pneumocystis pneumonia in the intensive care unitLocation, location, location |
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Critical Care Medicine,
Volume 26,
Issue 4,
1998,
Page 640-641
Robert Walker,
Robert J. Kaner,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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| 8. |
Unintended consequences |
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Critical Care Medicine,
Volume 26,
Issue 4,
1998,
Page 642-643
Thomas J. Papadimos,
Michael J. Murray,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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| 9. |
TracheobronchographyOld is not necessarily outdated-Especially for the young |
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Critical Care Medicine,
Volume 26,
Issue 4,
1998,
Page 643-644
Brahm Goldstein,
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ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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| 10. |
Reversal of late septic shock with supraphysiologic doses of hydrocortisone |
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Critical Care Medicine,
Volume 26,
Issue 4,
1998,
Page 645-650
Pierre-Edouard Bollaert,
Claire Charpentier,
Bruno Levy,
Marc Debouverie,
Gerard Audibert,
Alain Larcan,
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摘要:
ObjectivesPreliminary studies have suggested that low doses of corticosteroids might rapidly improve hemodynamics in late septic shock treated with catecholamines. We examined the effect of hydrocortisone on shock reversal, hemodynamics, and survival in this particular setting.DesignProspective, randomized, double-blind, placebo-controlled study.SettingTwo intensive care units of a University hospital.Patients48 hrs.InterventionsPatients were randomly assigned either hydrocortisone (100 mg iv three times daily for 5 days) or matching placebo.Measurements and Main Resultsor=to24 hrs without catecholamine or fluid infusion. Of the 22 hydrocortisone-treated patients and 19 placebo-treated patients, 15 (68%) and 4 (21%) achieved 7-day shock reversal, respectively, a difference of 47% (95% confidence interval 17% to 77%; p=.007). Serial invasive hemodynamic measurements for 5 days did not show significant differences between both groups. At 28-day follow-up, reversal of shock was higher in the hydrocortisone group (p=.005). Crude 28-day mortality was 7 (32%) of 22 treated patients and 12 (63%) of 19 placebo patients, a difference of 31% (95% confidence interval 1% to 61%; p=.091). Shock reversal within 7 days after the onset of corticosteroid therapy was a very strong predictor of survival. There were no significant differences in outcome in responders and nonresponders to a short corticotropin test. The respective rates of gastrointestinal bleeding and secondary infections did not differ between both groups.Conclusions96 hrs resulted in a significant improvement in hemodynamics and a beneficial effect on survival. These beneficial effects do not appear related to adrenocortical insufficiency. (Crit Care Med 1998;26:645-650)
ISSN:0090-3493
出版商:OVID
年代:1998
数据来源: OVID
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