摘要:

AbstractMicrocomputers have been used in our hospital for the past five years to summarize data from patients and to remind us to carry out routine tests. Recently, we have shown computer data on the screen to patients; this helps us to explain and discuss the monitoring of their condition with them.Unlike some other systems, general data as well as data on self‐monitored blood glucose levels are recorded in our computer system. The data consist of five categories: personal profile, treatment, etiological research, indices of control and data for checking complications.The analysis and evaluation of our system are done by the modes of display, statistical calculations, early detection of complications and graphics.The system is compatible with input from a keyboard, optical character readers and interface to a glucose meter with a memor

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00335.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00336.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractWe studied 65 insulin‐dependent diabetic children and adolescents diagonosed during the period 1976–86 to find out the occurrence and duration of postini‐tial remission, the relationship between the remission behaviour and the initial treatment introduced by continuous subcutaneous insulin infusion (CSII), the favoring factors and the prognostic value of remission. A postinitial remission occurred in 36 patients (55.4%) being complete in only two boys (3.1%). The mean duration was 10.8 months and median was 7.8 months: the shortest period one month and the longest 36 months. On the other hand, remission occurred in 16 out of 19 patients (84.2%) with CSII and 15 out of 37 patients (40.5%) with conventional treatment (CT) as initial treatment. The mean duration of remission was 14.6 ± 10.6 months in the CSII group and 6.8 ± 4.7 months in the CT group. Further, our study proved a significant increase of urinary C‐peptide excretion in the patients with CSII during their remission. Through our study in comparison with CT, we were able to see an improvement in the remission rate by introducing the CSII for a short term in the initial treatment and it led us to realize that what caused it was the recovery of endogeneous insulin secretion

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00337.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractIt is recognized that residual pancreatic /3‐cell function may play a role in the control of blood glucose in patients with insulin‐dependent diabetes mellitus (IDDM). Since modern therapy is concerned with the possibility of recovery of pancreatic β‐cell function, we need to identify the secretagogue of choice in the various phases of IDDM.Eleven patients with IDDM underwent four different stimulation tests of (3‐cell function over two weeks. The tests were i.v. arginine (ATT), oral glucose (o‐GTT), i.v. glucagon (GCT) and i.v. tolubutamide (TTT). One patient had the tests repeated four times over two years after the onset.Among the tests, ATT and o‐GTT produced the largest response ofC‐peptide. The response to GCT was small in comparison. TTT had no significant effect. The present study suggests that ATT or o‐GTT or both are useful in the evaluation of endogenous insulin secretion during follow‐up of IDDM. On the other hand, GCT can only be used as a simple screening method for residual ß‐cell function and is not sufficient for quantitativ

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00338.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractBecause of various circumstantial evidence, we have been asserting the streptococcal etiology of mucocutaneous lymph node syndrome (MCLS), although there has been no recoveryof Streptococcus pyogenesfrom the patients at any site.The present study was designed to provide a satisfactory explanation for the failure to isolate these bacteria from patients with MCLS, by electron microscopic observation of group A ftera‐hemolytic streptococci which had been inoculated intramuscularly into mice.“Spherical bodies” were detected in biopsy specimens obtained from the infection sites from 10 – 14 days onward after infection; these were spherical, 0.5–1.5yuain diameter, devoid of cell walls, perhaps uncultivable on any culture medium, and undistinguishable from those discovered in the buffy coat from peripheral blood of MCLS patients and described as ruined etiological microorganisms by Ueno et al.The implications of these findings, particularly in terms of the etiology of MCLS, were

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00339.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractThe absence of seroconversion to streptolysin O in convalescent patients with mucocutaneous lymph node syndrome has been a perplexing problem for investigators who are in favor of a streptococcal etiology of the disease. In the present studies, mice subjected in the newborn period to an infection with a strain ofStreptococcus pyogenes, which fails to confer cellular immuno‐responsiveness even in adult mice, and then reinfected four to six weeks later with another strain of the same species, which has an intrinsic ability to render mature murine hosts sensitive to streptococcal antigens, expressed an enhanced cell‐mediated immunity coupled with a lack of humoral responsiveness to the same antigens. Such immunological characters are an exact counterpart of those of MCLS patients. The involvement of these immunological characters in the pathological process of the disease is discus

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00340.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractDimethylsulfoxide (Me2SO) increased acid sphingomyelinase activity in cultured skin fibroblasts (Sakuragawa N et al., Biochem Biophy Res Comm 1985; 126: 756–762). Various drugs were examined to find related compounds showing the same phenomenon as Me2SO, including other dipolar aprotic substances, various inhibitors of DNA and RNA synthesis, phorbol esters, vitamin E and its derivatives and other miscellaneous agents. Several dipolar aprotic substances, such as Me2SO, dimethylacetamide, tetramethylurea and hexa‐methylene‐bisacetamide, increased the acid and Mg‐independent neutral sphingomyelinase activity in human cultured skin fibroblasts. These dipolar aprotic substances also increased acid and Mg‐independent neutral sphingomyelinase activities in Niemann‐Pick cells, type C, to 300 to 700% of those of untreated controls, repairing their enzyme deficiency. Other lysosomal hydrolases increased to a slightly lesser extent than sphingomyelinase. Dipolar aprotic substances could be used as therapeutic drugs for Niemann‐Pick di

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00341.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractFive former patients cured from acute lymphoblastic leukaemia (ALL), four women and one man, have six healthy children: three girls and three boys. The children were born in the period from 13 to 24 years since the beginning of the disease, and five to 16 years after therapy cessation. The treatment of the patients lasted eight to nine years.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00342.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractWe described the general clinical course of histidinemia in a previous report. Here, we report on five patients having particular problems in the developmental aspects.Case 1 was found to have histidinemia at the age of 3 years during a clinical survey of the nature of his neurological symptoms. He has been followed up for seven years. He developed poorly in verbal expression.Case II was detected by newborn mass screening. The psychomotor development was apparently normal, but in detail, the development of fine motor and cognitive function was insufficient during the follow‐up period. Consequently, a developmental lag in visual perception, visual motor perception and spatial perception were noted in this case.Cases III, IV and V were each 3 years old, and were also diagnosed as histidinemic by newborn mass screening test; scanty attachment and various kinds of autistic behavior were noted during their clinical course.These five cases were clinically different from other non‐symptomatic patients with histidinemia.It is important to study the pathogenesis of such psychomotor abnormalities from the viewpoint of psychological care for the child

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00343.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00344.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY