摘要:

AbstractMice with Niemann‐Pick disease were treated with bone marrow transplantation. The loss of Purkinje cells remained unchanged, but the accumulation of sphingomy elin and cholesterol was reduced in the visceral organs, especially in the spleen, three weeks after marrow graft. The activity of acid sphingomyelinase was increased in the grafted liver of mice, and in the spleen this activity was elevated to normal level

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1985.tb00617.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1985.tb00618.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1985.tb00619.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1985.tb00620.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

AbstractIn pediatrics, the offending microorganisms in lower respiratory infections have not yet been established. Our data based on 1,898 patients with lower respiratory tract disorders in children (1965–1979) demonstrated that washed sputum is of practical value in establishing the etiological diagnosis of bronchopulmonary infections in children. The criteria for the determination of the dominant or offending pathogens are presented.H. influenzae was found to be the leading organism, especially in patients having a recurrent or protracted course: its incidence was 64.1% in chronic bronchitis, 24.5% in recurrent or protracted bronchitis, 21.7% in pneumonia and 15.0% in acute bronchitis. H. influenzae seemed most significant in aggravating the signs and symptoms accompanying the infection. Recent bacteriological study of washed sputum (1980–1981) revealed an increasing frequency of H. influenzae as a causative agent.Ampicillin‐resistant H. influenzae strains have been demonstrated since 1976, and constituted 13.5% of 154 strains, while chloramphenicol‐resistant strains remained at 2.5% in 1982. The biotypes of ampicillin‐sensitive and resistant strains included not only types I and II but types

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1985.tb00621.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

AbstractThe fetal mortality, neonatal mortality and developmental outcome of 690 less than 1,500 gram infants born during 1974–78 in Denver, Colorado, USA, was studied. Comparisons were made of 393 babies born at University Hospital (UH) where an intensive intrapartum care program was established and 297 babies born in five metropolitan Denver hospitals (MDH) who did not have intensive care capability. They were usually transported to The Children's Hospital (CH), Denver, for neonatal intensive care. Fetal mortality was lower in the UH population than the MDH population; neonatal mortality in the UH and. MDH babies was not different above 700 grams; neonatal delay was least(8%) in the babies born to mothers transported to UH for delivery (UH‐MT) and highest (21%) in the MDH babies who were transported to CH for neonatalintensive care. The authors conclude that fetal survival improved at UH andthat mental delay is least in babies born to mothers who are transported to UH for perinatal intensive c

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1985.tb00622.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

AbstractThe incidence of periventricular‐intraventricular hemorrhage (PVH/IVH) in small premature infants diagnosed by computerized tomographic scanning (CT) is 40–50%. Ultrasound brain scanning is now emerging as an alternative modality for diagnosing PVH/IVH as early as the first day of life. Portability of the equipment and lack of ionizing radiation make this method ideal for studying newborn infants in intensive care units.In the present study the diagnosis of PVH/IVH was made using CT and ultrasound. Infants with PVH/IVH were then compared with infants in whom no bleeding was detected. The relationship between selected obstetric, neonatal, asphyxia1 and therapeutic factors and PVH/IVH was studied in a group of small premature infants. Statistically significant associations with respiratory distress, ventilator therapy, low Apgar score and metabolic acidosis were observed, lending support to their role in the pathogenesis of PVH/IVH.The prognosis of small premature infants suffering from post‐hemorrhagic hydrocephalus is probably related to the extent of the first insult and hemorrhage and the rate and extent of the development of subsequent hydrocep

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1985.tb00623.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

AbstractThe new diagnostic technique, positron emission tomography with18F‐DG, was used to obtain qualitative estimates of regional cerebral glucose metabolism in newborn infants with perinatal asphyxia, cerebral hemorrhage or focal motor seizures. Glucose metabolism of gray and white matter structures in the brain could be differentiated clearly. Decreased glucose metabolism was identified in regions of the brain shown by CT scan to be structurally abnormal. A localized increase in glucose metabolism was demonstrated in the contralateral cerebral hemisphere of a newborn with focal motor seizures. Positron emission tomography is a promising new diagnostic tool for study of newborn infants with supected abnormalities of brain functio

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1985.tb00624.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

AbstractSerum IgM and IgG antibodies against mumps virus and rubella virus were quantitated serially by enzyme‐linked immunosorbent assays in 15 children with Kawasaki disease. IgM antibody against mumps virus and IgG antibody against rubella virus were increased significantly in children with Kawasaki disease who had no previous history of mumps virus or rubella virus infection. Booster‐like effect in IgG antibody levels against mumps virus was observed in children with Kawasaki disease who had a previous history of exposure to mumps virus. Since none of the patients manifested clinical symptoms of mumps or rubella, the increased antibody levels against mumps and rubella may represent a part of the nonspecific increase in serum immunoglobulins in children with Kawasaki dise

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1985.tb00625.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

AbstractImmunoglobulin‐bearing peripheral blood lymphocytes were measured serially in 15 patients with Kawasaki disease. IgG‐bearing lymphocytes and IgMbearing lymphocytes were increased significantly during the acute phase of the disease (p

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1985.tb00626.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY