摘要:

AbstractWe succeeded in the early diagnosis of pneumoperitoneum in a low birth weight infant with neonatal necrotizing enterocolitis by transillumination. Transillumination is a simple and noninvasive technique which can be used in the evaluation in risk infants to detect pneumoperitoneum at the earliest possible time. In the large series of 296 neonates admitted to NICU over a period of 3 years, there was a sharp increase in the incidence of abdominal distension and/or intestinal bleeding with decreasing birth weight and gestation, indicating that neonatal necrotizing enterocolitis is dependent on the degree of prematurity. We therefore postulate that the disease could be termed “Enteropathy of Prematurity”. In infants with abdominal distension and/or intestinal bleeding, the routine use of transillumination may help the early detection of penumoperiton

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00527.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstructBy using McDonald's pressure transient method, damping of the various systems of manometry at various frequencies was evaluated from the view point of amplitude and phase lag. Damping expressed by the natural frequency (ωo) of vibration of the system of pressure measurement and the relative damping (β) varied widely depending on the combinations of various catheters and connectors. Damping increased as the radius of the catheter decreased and by the attachment of the three way stop‐cock.In view of the fact that intracavitary pressure is composed of the sum of the first 5 to 6 harmonics of the fundamental frequency (heart rate), the degree of damping by two different catheter manometer systems was compared with each other (one with a 5F size NIH catheter, another with a 8F size NIH catheter) using the rectangular pressure contour as a reference input.Based on these results, importance was emphasized of giving sufficient consideration to the kind of catheter and type of connector used in cardiac catheterization of child

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00528.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractA total of 21 patients with linear growth retardation were treated with low doses of oxandrolone for a period of 8 to 41 months. Nine of the patinets had chromosomal disorders. The other 12 had no chromosomal abnormalities.The effect of oxandrolone on the ultimate adult height was assessed by changes in the ratio of the height age and the bone age, (δHA/δBA), and by the adult height prediction (AHP). In the non‐chromosomal group, the ultimate height prediction improved in patients whose initial bone age was greater than 8 1/2 years. In the group with chromosomal disorders, no change in ultimate height prediction occured. In Turner's syndrome, the adolescent growth spurt is much less than in normal children. Therefore, the data were interpreted to signify probable beneficial response to therapy. Evidence suggests that low dose oxandrolone treatment does not compromise ultimate height. Since it may induce an acceleration of growth rate on a short term basis, it can help ameliorate psychological problems due to poor body image in these short patie

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00529.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00530.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractA patient whose tuftsin‐activities of serum and PMN had been found to be deficient was reported in 1975 by us. After the elapse of 4.5—5.5 years, tuftsin‐activity in addition to chemotactic, bactericidal and NBT‐reducing activities of the the patient's PMN were investigated. The tuftsin and bactericidal activities againststaphylococcusof the patient's PMN fell within the normal range. However, as to the NBT‐test and chemotaxis, the patient and her sister who had suffered from similar symptoms in infancy were found to have lower activities. In addition, the serum IgE level of the patient was slightly higher.It is obscure as to why the patient's tuftsin‐activity recovered to a normal level, although she has not received γ‐globulin therapy for 5.5 years.It is conceivable that the patient suffers from a dysfunction of PMN, but it is impossible at the present time to make a defi

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00531.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractPulse‐mode methylprednisolone therapy was instituted in the treatment of idiopathic thrombocytopenic purpura (ITP), both acute and chronic forms. This regimen induced a rapid increase in the platelet count in a short time and was less toxic than the conventional mode of therapy, i.e. oral steroid hormone administration. This regimen is of value in the management of patients with ITP who are at the substantial risk of fatal hemorrhage. And this is also useful as a short‐term presplenectomy preparation or as a “medical splenectomy” program. Impressive responses in our experience encouraged us to evaluate this mode of

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00532.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractSince prostaglandin E1>(PGE1) has been used for congenital cyanotic heart diseases of PDA‐dependent type due to its ductus dilatation effect, it is now possible to perform shunt operations with recovery of the general condition. Simultaneously, however, various side effects have been reported. In recent years, periosteal hypertrophy has been attracting attention as a side effect after long‐term administration of PGE1. In this study, the authors administered 0.03 μg/kg/min of PGE1intravenously to an infant with a single ventricle and pulmonary atresia from the 7th day after birth.On the 9th day after the onset of administration, swelling and pain appeared in the lower limbs and later in the upper limbs. X‐rays of the lesions revealed hypertrophy of the periosteum. After administering PGE1for 98 days, a shunt operation was performed, and a biopsy of the right tibia was conducted. Microscopic examination of the biopsy specimen showed marked new osteogenesis due to woven bones, and resorption, including osteoclasts, presumably attributable to a reaction specific to woven

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00533.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractHistopathological changes were studied in renal biopsy specimens from a ten‐year‐old boy diagnosed as having Alport's hereditary nephritis with the nephrotic syndrome. Biopsy specimens of the kidney showed mild hypercellularity with an increase of mesangial matrix, irregular thickening of the capillary walls in the glomeruli, and numerous clusters of interstitial foam cells by light microscopy.Granular deposits of IgG, IgM, C3 and fibrinogen were seen along the capillaries and partially in the mesangium by immunofluoroscopy.Ultrastructurally, the lesions had various abnormalities of the glomerular basement membrane, including splitting, thinning, disruption, reticulation and irregular thickening. The mesangial matrix was increased and intramembranous deposits were observed. Foam cells were seen among both tubular and interstitial ce

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00534.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00535.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractThe heredity of hypohidrotic ectodermal dysplasia (HED) has been considered to be X‐linked recessive, autosomal recessive or autosomal dominant. In this report, a genetic analysis was carried out on a total of 57 patients with HED including 6 patients recently examined by the present authors and 51 patients reported in Japan before May, 1980.The morbidity varied depending on sexes, being significantly higher in men than in women (p<0.001). Consanguinity was positive in 12.8% of the patients. The segregation ratio calculated, however, suggested that an autosomal recessive trait did not account for all the cases. The pedigree analysis and the segregation ratios revealed that HED was probably not autosomal dominant. It is finally pointed out that the heredity of all the patients with HED reported in Japan might be X‐linked recess

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00536.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY