ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00867.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00868.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

To examine the effects of E‐64 (a thiol protease inhibitor) on the development of rat embryos, pregnant Wistar rats were injected with 10–30 mgkg of E‐64 intra‐peritoneally on days 9 and 10 of gestation. On day 21, the rats were killed and the fetuses were examined for malformations. When 30 mgkg of E‐64 was administered, the incidence of resorptions and malformations was 25.7% and 60.4%, respectively, The most common malformations were hydrocephaly, exencephaly, anophthalmia, microphthalmia, hydronephrosis and renal hypoplasia. “hew results suggest that thiol protease inhibitor is teratogenic during early rat em

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00869.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Sodium valproate was administered to Jc1:ICR mice in order to evaluate its teratogenicity. A single dose of 600 mg/kg of sodium valproate was injected intrapentoneally on gestational day 6, 7, 8 or 9. On day 18 of gestation, dams were laparotomized, and live fetuses were inspected for the presence of external and internal abnormalities. Exencephaly and urogenital abnormalities showed the highest frequency in the group treated on day 8, being recognized in about 60% and 10% of live fetuses, respectively. Cardiovascular abnormalities were found in the highest frequency in the group treated on day 7 (in about 30% of live fetuses). Incidence of tail abnormality was found to increase with delay in day of drug administration. Other abnormalities observed were cleft palate and digital malformation. Our study showed that a constellation of major abnormalities similar to the congenital valproate syndrome suspected in humans could be produced in the Jc1:ICR mouse fetus.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00870.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Many toxic neutrophils, characterized by cytoplasmic swelling, vacuolization and toxic granulation, can be seen in the acute phase of Kawasaki Disease (KD; mucocutaneous lymph node syndrome). Polymorphonuclear neutrophils (PMNs) of 36 patients with acute and convalescent phase KD were studied with reference to their morphological characteristics. The percentage of toxic neutrophils in the acute phase tended to be higher in the group with coronary artery lesions (CAL) than in the group without CAL. The results suggest that observation of toxic neutrophils in the acute phase of KD may be useful in predicting a high risk of CAL.In vitrocultivation studies of PMNs from healthy persons, in the presence of diverse hematopoietic colony‐stimulating factors (CSF), revealed that GM‐CSF (granulocyte‐macrophage‐CSF) and G‐CSF (granulocyte‐CSF) participated in the induction of cytoplasmic vacuolization of PMNs, and that the healthy PMNs morphologically mimicked peripheral PMNs seen in the acute

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00871.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Thirty‐six (17.8%) of 202 children with acute lymphoblastic leukemia (ALL) and 2 (3.7%) of 54 children with acute nonlymphoblastic leukemia (ANLL) had a platelet count over 150 times 109/1 at diagnosis. Children with ALL and a platelet count over 150 times 109/1 were analysed in detail. The ALL patients without thrombocytopenia tended to be male predominant and had less frequent bleeding manifestations (p<0.01).These patients without thrombocytopenia had also significantly less marked leukocytosis (p<0.01), less severe anemia (p<0.05) and lower percentages of bone marrow blasts (p<0.05) than those with thrombocytopenia. In addition, ALL patients without thrombocytopenia had a significantly higher probability of continuous complete remission than those with thrombocytopenia (p<0.01

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00872.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Plasma catecholamine concentration (CAT: adrenalin and noradrenalin) and plasma renin activity (PRA) were measured in 26 children, aged 10 to 15 years, who had difficulty waking up in the morning. CAT, which was examined only in the supine position in control children, and PRA, which was examined before and after standing for 15 min, were significantly lower than in age‐matched control children. These results suggest that low CAT and PRA may contribute to difficulty waking up in the morning in childhoo

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00873.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

We recently found many cases of gastroenteritis involving older children and sometimes other members of their families. We suspected epidemiological infiltration of an atypical rotavirus (RV). PAGE analysis of 130 cases in 1985 and 1986 revealed that the RNA profiles were similar to that of group C RV in 12 cases. We performed IEM analysis on one of the strains and found it to be group C. The group C RV was detected for 2 months toward the end of the outbreak of group A RV infection. The ages of the group C RV infected patients were 4 years or older. We also studied the prevalence of antibody to group C in the stored sera that had been collected since 1971. Antibody was seldom found in the sera of patients under 3 years of age but it was found in 20–40% of those who were 4 years or older. The clinical manifestations of the group C RV infection were similar to those of group A, except that body temperature was slightly lower and other symptoms were generally milde

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00874.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The purpose of this study was to determine whether left ventricular (LV) diastolic function in children with high blood pressure (BP) is abnormal. We measured the corrected LV isovolumic relaxation time (IRT), peak velocity of increase in LV dimension (dD/dt) and the LV muscle volume in a high systolic BP tracking group (10 boys and 22 girls) and a low BP tracking group (22 boys and 11 girls) at 3‐year intervals from the ages of 6 to 15. The corrected IRT of the high BP tracking group was significantly longer than the low BP tracking group. Left ventricular dD/dt/D of the high BP tracking group was significantly lower than the low BP tracking group from the ages of 12 in boys and 9 in girls. The left ventricular muscle volume index of both groups, however, was not significantly different. Both corrected IRT and dD/dt/D were well correlated with diastolic BP. These data suggest that children in the high BP tracking group might have LV diastolic abnormalities from age 12 or 15, in contrast to children of the low BP tracking group, without increased LV muscle volume. Therefore, it might be useful to examine BP and LV function of children from ages 12 or 15 for prevention of hypertensio

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00875.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Serum levels of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL‐C), low density lipoprotein cholesterol (LDL‐C) and fructosamine (FA) were determined in thirty–three children with malignant diseases and twenty healthy controls aged 1–14 years. Of them, FA was the parameter measured in children with malignancy for the first time. Mean serum TC, HDL‐C, LDL‐C and FA showed statistically significant decreases in malignancy compared to healthy children, whereas a statistically significant increase was observed for TG concentrations in serum. From these data, we conclude that significant relations between serum lipids and lipoproteins and the state of malignancy exist in the children studied, and it should be remembered that serum FA concentrations are affected by abnormal serum protein turnover when one deals with any type of neoplas

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00876.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY