ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00818.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00819.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Increased production of active oxygen species from activated neutrophils is postulated to contribute to endothelial damage in Kawasaki disease, leading to the formation of coronary aneurysms. To determine wheather an altered oxidant‐antioxidant balance exists in acute phase of Kawasaki disease, antioxidant enzymes in peripheral blood cells and Plasma lipid peroxide were measured in patients. The two isoenzymes of intracellular superoxide dismutase were assayed by specific radioimmunoassays. Lipid peroxide in plasma and manganese superoxide dismutase in both polymorphs and lymphocytes were increased in the acute phase of Kawasaki disease. The erythrocyte alutathione peroxidase and catalase were also increased. On the other hand, copper zinc superoxide dismutase in polymorphs, lymphocytes and erythrocytes was unaltered. Acute infections did not appear to modify the levels of either antioxidant enzymes or lipid peroxide in blood. These results suggest that increased oxidative stress in Kawasaki disease evokes a reactive increase in antioxidant enzymes, and that this response in the defense system is related ot the reversible nature of the tissue damage in most patients with Kawasaki diseas

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00820.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The serum levels of glycated albumin (GA) in 83 non‐diabetic children and 26 children with insulin‐dependent diabetes mellitus (IDDM) were measured by high‐performance liquid chromatography (HPLC). In non‐diabetic children over one year, the GA levels were found to be uninfluenced by age, while the fructosamine (FRA) levels increased with age. The mean level of GA in IDDM children was 39.1±9.1%, which was significantly higher than in non‐diabetic children with values of 16.1±.1% (p<0.01). The GA levels of non‐diabetic and IDDM children did not overlap, whereas their FRA levels did overlap. The GA levels correlated with HbAlc levels (r=0.74, p<0.01) and FRA levels (r=0.66, p<0.01) in IDDN children. The GA levels were more closely correlated than the FRA levels with the blood glucose two and three weeks previously. Thus, the GA level is a useful indicator of shortterm control in diab

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00821.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The urinary excretion of dicarboxylic acids in X‐linked adernoleukodystrophy (X‐ALD) was studied. The dicarboxylic acid profile in X‐ALD did not show any specific pattern, unlike Zellweger syndrome and neonatal adernoleukodystrophy. Medium‐chain dicarboxylic acids with an even number of carbon atoms (adipic, suberic, sebacic) and an odd number of carbon atoms (pimelic, azelaic) were excreted within the normal ranges. Dicarboxylic acids with more than 10 carbon atoms were not found. Thes findings may be due to the normal beta‐oxidation system of dicarboxylic acids

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00822.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Xeroderma pigmentosum complementation gropu A(XPA) is one of the DNA repair deficient syndromes. The cell biological features of XPA were examined by flowcytometry using Epstein Barr (EB) virus‐transformed lymphoblastoid cells. Cellular sensitivity to vincristine (VCR), etoposide (VP‐16) and methotrexate (MTX) were assayed by DNA pattern changes by flowcytometry. Recently, ataxia‐telangiectasia (AT), one of the same kindof disorder, has been reported to have an increased sensitivity to VCR and VP‐16. Howerver, AT showed some resistance ot MTX according to other reports. Our results showed that XPA had an; increased sensitivity to VCR and also to VP‐16. Moreover, different from AT, XPA showed some sensitivity to MTX. Thus there is some cell biological similarity between XPA and AT, as well as some difference of the abnormality in the DNA repai

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00823.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

In order to estimate the prevalence ofparagonimus westermaniamong the school children in Ulchin county, Kyungpook Province, five primary schools were selected for sampling. The children were first examined using an intradermal test withParagonimusantigen, Lot No. 890417, and then examined forParagonimuseggs from suuta and stools collected from the intradermal‐positive cases. In a total of 382 children examined, 53 cases or 13.9 percent revealed positive reactions forParagonimus westermani. The sex specific rate of infection was a little higher in boys than in girls. The age specific rate ofParagonimus westermaniinfections varied from age to age.Paragoniums westermaniwas most prevalent in the 8‐year‐old group in both sexes and showed about the same proportion among boys and girls of each age group. A comparison of the reliability for the detection ofParagonimuseggs from intradermal positive cases in this study showed that the sputum test was more sensitive than the stool test. Summarizing the results, this study indicates that the prevalence ofParagonimus westermaniis still high and the endemic foci of the fluke exists in Ulchin county, Kyungpook Province,

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00824.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

We analyzed the relations between blood pressure in sitting and supine positions, left ventricular mass (LVM) and Doppler aortic, pulmonary and mitral flow velocity measurements in 163 healthy school children. Systolic blood pressure in a supine position correlated significantly with aortic acceleration (ATc) and ejection time)ETc), corrected by the square of R‐R interval, pulmonary AT and peak flow velocities. Moreover, the systolic blood pressure in a sitting position correlated with pulmonary AT and LVM. LMV correlated with pulmonary ATc, the ratio of AT to ET andaverage acceleration, and aortic ETc and peak flow velocity. These data suggest the following: (1) the posture influences the relation between blood pressure and flow velocity, (2) pulmonary hemodynamics are influenced by systemic blood pressure in healthy children and (3) the development of LVM may be dependentnot only on blood pressure but also on cardiac work in childhoo

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00825.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

We investigated the changes of left ventricular isovolumic relazation time (LVIRT) with growth and the factors influencing them during childhood, in a 10‐year follow‐up stury.We measured the body height(BH), body weight (BW), lean body weight (LBW), heart rate (HR), Blood pressure (BP), left ventricular muscle volume index (LVMVI), and LVIRT corrected by the preceding R‐R interval) IRT/R‐R), of 187 healthy children at 3‐year intervals (6,9,12,15 years old). IRT/R‐R were prolonged with growth in boys and girls. At the ages of 12 and 15, the IRT/R‐R of girls were longer than those of boys. Significant correlation coefficients for IRT/R‐R on systolic and diastolic, BW and LVMVI were 0.28, 0.31, 0.20, 0.28, respectively. These data suggest that(1)IRT/R‐R is mainly determined by the diastolic BP,(2) left ventricular diastolic function of children develops with growth of body size, especially BW, and(3) left ventricular early diastolic function in adolescents isrelated to

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00826.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

(1) Continuous intravenous infusion (2–10 μ/kg/min) of nitroglycerin (TNG) was administered to 20 neonates consisting of 17 with refractory congestive heart failure and 3 with PFC (Persistent Fetal Circulation). (2) AT doses of 2–4 μ/kg/min, there were no significant changes in heart rate or systemic blood pressue. (3) At doses of 2–4 μ/kg/min, the CVP was significantly reduced and urnary output increased. (4) Echocardiograms revealed a significant decrease in LVS at 4 – 5 μ/kg/min. In addition, the EF and cardiac output were significantly increased at 2 – 5 μ/kg/min. (5) The right ventricle systolic time interval (STI) was reduced significantly at 2 μ/kg/min. The left ventricle STI was not reduced below doses of 4 μ/kg/min. (6) In the dose range 2 – 5 μ/kg/min, TNG is an effective and safe vasodilator in the treatment of refractory congestive heart failure

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1990.tb00827.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY