摘要:

AbstractThe frequencies of pre‐B cells and B lymphocytes subpopulations were studied in 43 cord blood and 21 adult peripheral blood samples using a direct immunofluorescence double staining method.We found pre‐B cells in 40 out of 43 cord blood samples studied, a rate of 93%, and in 16 of 21 adult blood samples, a rate of 76%. The mean frequency of pre‐B cells in cord blood lymphocytes was 0.7%, while that in adult blood lymphocytes was 0.2%. The pre‐B cells in both groups were all small pre‐B cells.The mean frequency of B lymphocytes in cord blood was 11.4%, higher than that in adult blood (5.4%). The difference in B lymphocyte frequency between cord blood and adult blood was exclusively due to high frequency of surface IgM‐positive and IgD‐positive B lymphocytes in t

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00032.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractImmunoreactive polymorphonuclear leukocyte elastase (iPMN elastase) was measured by ELISA in 36 patients with Kawasaki disease and in 41 patients with anaphylactoid purpura and other infectious diseases of childhood. The iPMN elastase level was very high in Kawasaki disease compared with other diseases. There was no significant correlation in iPMN elastase levels in Kawasaki disease between the complicated and non‐complicated groups in the acute period. The iPMN elastase in the non‐complicated group fell below 250 4g/1 at 20 days from the onset of the illness. However, iPMN elastase in the complicated group (coronary aneurysm or dilatation) tended to remain high above 500ligjlat 20 days from the onset. We suggest that increased iPMN elastase levels in Kawasaki disease reflect stronger enhancement and stimulation of PMN than in other disea

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00033.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractLymphokine‐activated killer (LAK) activity was studied in 29 children with acute lymphoblastic leukemia (ALL). Peripheral blood lymphocytes of the patients and normal volunteers were cultured in the presence of recombinant‐interleukin 2 (R‐IL2) for five days, and assayed for their LAK activities by51Cr release assay using Raji cells as a target. At the time of onset, LAK activity was 4.3±2.6% (mean±SD, n=6) compared to the normal value. During remission LAK activity improved to 49.6±30.2% (n=16, p<0.01). After cessation of therapy LAK activity further improved to 97.3±21.2% (n=7, p<0.01). The conventional anti‐leukemic agents appeared to be suppressive for LAK activityin vitro.Of the patients in remission for more than one year, three with depressed LAK activity relapsed one to four months after the assay. Although it still remains undetermined whether the depression of LAK activity is responsible for the subsequent relapse, the application of adoptive immunotherapy using LAK and R‐IL2 is of clinical interest because it can be expected to enhance the activity of LAK. As compared with natural killer cell activity in childhood ALL, LAK activity showed a prompt improvement af

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00034.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractTesticular volumes of Japanese males from birth to adolescence were studied in cross‐sectional series. Maturational events of testicular volumes occurred in the two periods during early infancy and adolescence. The testicular volumes during the first three months of life were slightly greater than later in infancy. Thereafter there was very little increase in testicular volumes from the age 1 to 10 years. After 11 years there was a sudden increase in size. The mean volumes increased from 6.5 cm3at the age of 11 years to 36.7 cm3at 14 years. The largest increment was observed between 13 and 14 years of age and between pubic hair stages I and II. Reaching testicular volumes of 6.5 cm3was found to be a landmark of the earliest sign of puberty. The age at which pubertal development was initiated varied between the ninth and the fourteenth year of lif

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00035.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractPenile lengths of Japanese males from birth to adolescence were studied in cross‐sectional series. The mean length of the penis in 5 days term newborn was 2.9 ± 0.5 cm (M ± SD). There was a gradual increase in penile length from the age 1 to 11 years. After 12 years of age there was a sudden increase in length. The mean length increased from 5.5 ± 1.5 cm at the age of 12 to 8.3 ± 0.8 cm at 14 years. The largest increment was observed between the age of 13 and 14 years. Mean penile length increased from 4.9 ± 0.8 cm at stage I of pubic hair development to 7.2 ± 1.4 cm at stage II and 9.0 ± 1.0 cm at stages IV‐V. The largest increment was observed between stage I and stage II of pubic hair development. This new reference of penile length can be helpful in those cases in which the children is suspective of having genitals of abn

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00036.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractTo investigate the relationship between histidinemia and developmental disorders, a longitudinal study was performed in 26 patients. Neuropsychological and psychological testing was carried out. The results indicate the range of DQ and IQ for these subjects, and suggest an autistic tendency and poor language/ visual abilities. Abnormal EEG patterns were observed.The relationship between histidinemia and brain dysfunction is descussed.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00037.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractIn 1984, Peter Dunn postulated that infants from 28 weeks ‘gestation till 18 weeks’ postnatal age who grow normally have almost identical potential growth velocities, regardless of racial and geographic differences. He suggested that the straight line growth curve in this period could be used as a perinatal growth chart for international reference. We composed biological growth curves for Japanese fetuses by eliminating data with risk factors for fetal growth, and compared them with the curves of Dunn. Our conclusions are as follows:1) Japanese population fetal growth curves correspond with the curve of Dunn between 28 and 38 weeks' gestation.2) Even in ideal conditions, flattening of fetal growth after 38 weeks' gestation always occurs.3) In the early postnatal period, infants grow with the same straight line velocity as during fetal growth between 28–38 weeks' gestation. Infants from 28 weeks' gestation to 18 weeks' postnatal age have an almost identical growth potential in spite of some degree of growth constraint in utero after 38 weeks' gest

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00038.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractThe rates of behavioural deviance in Japanese children attending school in England were investigated. A cross‐cultural comparison using the Rutter teachers' questionnaire was made between these Japanese children and some English children, which showed considerable similarity between the two sets. Possible additional ways teachers might identify Japanese children with deviant behaviour were described. These included teachers' ratings of “school failure,”“nurse's room user” and “not being liked by others.” The self‐concept of these Japanese children was also explored using the Piers‐ilarris children's s

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00039.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractAn electrocardiographic measurement useful in the diagnosis of right ventricular overload, involving precordial T waves, is presented. The longest Q(R) to T peak interval from V3Rto V4(V5) was longer than or identical with the same interval in both V5and V6(V7) when hemodynamic right ventricular overload was present. Sensitivity was greater when volume overload was present than with pure pressure overload. In contrast to the non‐specificity of the vectorcardiographic horizontal T loop, inscription and contour, the newly presented corresponding electrocardiographic parameter proved to be a simple, sensitive and specific discriminator of right ventricular overload. Discrepancy in diagnostic usefulness between the two systems (EKG versus VKG) is discussed in terms of proximity effects in precordial lead

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00040.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractLeigh's syndrome is a clinically heterogeneous disorder with a variety of biochemical bases. It is classified as one type of the mitochondrial encepha‐lomyopathies (MEMs). Serial auditory brainstem responses (ABRs) in eight patients with clinically diagnosed Leigh's syndrome are reported. Abnormalities of ABRs were detected in the early stages of the disease in all patients. Severely abnormal wave configuration associated with prolonged wave latency was detected in patients with apnea and/or other symptomatology involving the brainstem. Patients with cortical involvement had markedly abnormal ABRs in which only waves I and/or V were present. In those patients whose clinical symptoms were less severe, the ABR was mildly abnormal. Changes in the ABR did not consistently reflect clinical exacerbations and remissions. ABRs were useful in the classification of Leigh's syndrome and in judging the severity of the disease process. ABRs can be used as a supplementary diagnostic procedure in Leigh's syndrom

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00041.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY