ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00503.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractFor the prosperity of Japan in the 21st century, we pediatricians play a very important role in securing the health of future adults. Although our infantile death rate has become one of the worlds lowest recently, the number of neonatal deaths can further be reduced by preventing infections and accidents. Because of the huge consumption of antibiotics in Japan for past decades, the drug resistance of pathogens has increased remarkably and we are forced to choose potent new antibiotics for saving neonatal lives. Some unsolved problems associated with GBS infection in Japan are mentioned and the necessity of development of immunopotentiators as well as chemotherapeutics and vaccines in treating neonatal infections is discussed.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00504.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractAs assessed inNocardiamitogen system, B cell differentiation ability and T cell help for IgM‐production appeared to be nearly maturated at birth, but those for IgG‐ and IgA‐production were still deficient in cord blood and required much more time for their maturation. Deficit in concanavalin A‐inducible humoral suppressor activity and marked excess in pokeweed mitogen‐inducible one were peculiar properties of T cells in the early developmental period of life. The T cell subset in cord blood defined by OKT4 monoclonal antisera was much more suppressive on B cell differentiation than did another OKT8+subset, suggesting functional aberration of cord T cell subsets from corresponding a

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00505.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractIn order to evaluate the immunological functions of neonates on the cellular base, various in vitro functions of cord lymphocytes were studied. The ability of B‐cells to differentiate into immunoglobulin (Ig) producing cells and that of T‐cells to help the differentiation of B‐cells were quite insufficient in cord lymphocytes. Most of cord T‐cells suppressed Ig production from adult lymphocytes, which indicated the activation of suppressor T‐cells. This suppression seemed to be mediated by humoral factor(s) and to be the result of activation of both suppressor and suppressor‐inducer among cord T‐cells. The killer T‐cell activity against allogeneic cells seemed to be fully developed. However mitogen induced cytotoxicity of T‐cells was low in most cases. Natural killer activity of cord lymphocytes was variable accordi

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00506.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractCulture supernatants from unstimulated cord blood mononuclear cells (CBM) inhibited the proliferation of lymphoid cells of adult and newborns in semisolid cultures and the T‐cell‐rich fraction was found to have mainly this suppressor activity. On the 3rd to 5th day of incubation of CBM, maximal inhibitory activity was found to occur. In contrast, suppressor activity of the culture supernatant was effectively abrogated, when the CBM were incubated for 48 hr with phytohemagglutinin‐P (PHA‐P), concanavalin A (Con A) or protein A added at the concentration of 50 ug/ml or with 1 /ug/m/ of poke‐weed mitogen (PWM) and returned to a mitogen‐free medium for an

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00507.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractFive hundred and forty three cases were collected in a nation‐wide survey and registration of the primary immunodeficiency diseases in Japan.Among them nineteen cases (3.5%) were diagnosed during the first omit month of life, including ten cases of thymic hypoplasia, four of severe combined immunodeficiency, two of Wiskott‐Aldrich syndrome, one of chronic granulomatous disease and two of Chediak‐Higashi disease.Thymic hypoplasia was diagnosed in the neonatal period so frequently that among all 26 reported cases ten (38.5%) the diagnosis was made by one month of age from characteristic complications such as tetany and congenital anomaly of the heart and great ve

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00508.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractChildren may suffer from deficiency of one or more of the IgG subclasses‐ although the total level of IgG may be normal‐resulting in recurrent bacterial infections. Subclass deficiency may also be seen in some other well‐defined immuno deficiency states, i. a. selective IgA deficiency. Thus, IgG2 deficiency was found in 5 of 22 such children with symptoms of various diseases. Normal IgG2 levels were found in sera from 11 healthy individuals with selective IgA deficiency. IgGl levels of the whole IgA deficient group were significantly increased as compared to a normal reference

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00509.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractThe effect of AFP on in vitro anti‐SRBC PFC response was evaluated in order to clarify the mechanism by which the immunosuppressive activity of AFP was exerted. T/μ and Tγ cells were precultured with AFP and these precultured cells were added to the in vitro lymphocyte culture system. Anti‐SRBC PFC response was more significantly inhibited with the addition of AFP‐precultured Tμ cells than with AFP‐precultured Tγ cells. These results indicated that the immunosuppressive activity of AFP might be mediated by Tμ (helper T) cells. The possible mechanism of immunosuppression during the fetal and neonatal periods a

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00510.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

We have analysed cytotoxic antibody against T lymphocytes (TLFA) in cord IgM. TLFA IgM bound to T lymphocytes as determined by the radio immuno assay. TLFA IgM inhibited lymphocyte blastogenesis induced by Con A and PHA but did not inhibit that induced by PWM in the presence of complement. Based on these results, further studies were done to determine which function(S) of Con A‐ and PHA‐induced lymphocytes could be inhibited by TLFA IgM. TLFA IgM inhibited Con A‐induced T cell activity to suppress PWM‐induced antibody formation and autologous mixed lymphocyte culture. In addition, TLFA IgM markedly inhibited PHA‐mitogen factor induced killer T cell colony formation and their activity as determined by the colony assay and lymphocyte‐mediated cytolysis using K562 and Daudi cell lines respectively. TLFA appears to play a role in protecting a fetus from immunologic rejection by the mother, by killing maternal killer cells which may trasfer across the placenta and harm the fe

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00511.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1980.tb00512.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY