摘要:

SummaryAcute severe asthma in children should be managed by immediate attention to the patient's clinical condition. Careful observation, the use of sequential pulmonary function tests and appropriate blood gas studies will facilitate evaluation of severity. Therapy should be directed at the reversal and7sol;or correction of these abnormalities as well as anticipation of early treatment of potential complications. By the aggressive management of this condition, the incidence of complications can be reduced, the length of hospital stay shortened and substantial morbidity and possible mortality minimized.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00382.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractSmall doses of trypan blue (TB) and anti‐heart serum (AHS) were intraperi‐toneally injected into pregnant Wistar rats to produce in the offspring cardiovascular malformations, which in our previous studies had been induced by the combined use of anti‐sera to two tissues. The results showed that TB could produce a high incidence of malformations, though a dose of 10 mg/kg was subteratogenic in rats. AHS alone was not teratogenic even if 9 ml/kg were administered. Combined use of 10 mg/kg of TB (on day 9 of gestation) and 9 ml/kg of AHS (on day 10) produced a statistically significant increase of malformations (p<0.001). The total incidence of malformations and the incidence of those of the cardiovascular system were 91.5% and 83.1%, respectively. Ventricular septal defects and aortic arch anomalies were the main cardiovascular malformations. Localization of TB in both the yolk sac and the developing embryo was comfirmed, though deposition of AHS was not detected. In this study, the incidence of cardiovascular malformations was higher than that achieved in our previous study, which utilized a combination of small doses of anti‐kidney serum

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00383.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractSerum taurine concentration in the human fetus (umbilical blood) and neonate was measured from the 24th to 40th week of pregnancy. The concentration was considerably higher than in maternal serum with a peak at the 24th week of pregnancy and then a gradual decrease until it approached the adult level on the 9th day after birth.To clarify the underlying mechanism of the human findings, the distribution of14C‐taurine was investigated after intravenous injection to maternal rats on the 20th day of pregnancy. The taurine administered to the maternal side became concentrated in the placenta and reached the fetus. It was confirmed that taurine accumulated in the human placenta was present in a higher concentration than any other free animo acid.Placental transport of taurine was studied in isolated brush border microvillous plasma membrane vesicles by a rapid filtration technique. The membrane vesicles exhibited uptake of H3‐labeled traurine into an osmotically reactive intravesicular space. Taurine uptake by vesicles was stimulated specifically by an inward sodium gradient, and replacement of NaCl in the transport medium by KCl, LiCl or choline chloride had no effect on the transport activity of the vesicles. Taurine transport was inhibited competivively by the presence of β‐alanine and GABA. The initial rate of transport followed saturation kinetics with respect to taurine concentration: an apparent Km of 0.22 mM and Vmax of 67 pmol/mg protein were calculated in 20 seconds. These results indicate that transport of taurine across the placental brush border membrane is sodium‐dependent and carrier‐mediated.The taurine transport system in human fetal small intestine, especially in the jejunum, is a passive transport system quite unlike that of other amino acids.Reabsorption of taurine through the proximal convoluted tubule is by active transport which depends on sodium. This transport system is developed from the 24th to the 32nd gestat

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00384.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractUsing spontaneously established autologous lymphoblastoid B cell lines (LCL), killer cell activities were studied in children with severe infectious mononucleosis (IM), chronic IM, and acute IM, and compared with those in EBV‐seropositive normal controls. Natural killer (NK) cell activity of fresh peripheral blood mononuclear cells (PBMC) was normal in acute IM patients, but it was low in four of six patients with severe or chronic IM. Recombinant inter‐leukin 2 (rIL‐2)‐activated PBMC from normal controls showed lymphokine‐activated killer (LAK) cell activity against the respective autologous LCL. The levels of LCL lysis by LAK cells were significantly higher in acute IM patients, lower in chronic IM patients, and much lower in severe IM patients. In contrast to the fact that PBMC stimulatedin vitrowith autologous LCL (IVS cells) from normal controls and acute IM patients showed potent killing of autologous LCL, IVS cells from severe or chronic IM patients showed lower levels of LCL lysis, which were markedly augmented in three patients by rIL‐2 addition to the cultures. These killer cell dysfunctions appear to be responsible for the severe or chronic course of EB

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00385.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractAn attempt was made to combine anticoagulant therapy with gabexate mesilate and urokinase in a case of purpura fulminans developing after varicella infection. One week after the initiation of the treatment, the gangrenous extremities fully recovered without significant tissue necrosis. This is probably the first case of treatment of the disease that brought an immediate result.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00386.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractFifty‐five children with acute asthma were studied to evaluate the relationship between pulmonary function (improvement in forced expiratory volume in one second, FEVj, and maximum flow at 50% vital capacity, V50) and serum theophylline concentration after intravenous aminophylline.Serum theophylline concentrations and pulmonary function were measured before and after aminophylline therapy.In our study, there was significant improvement in pulmonary function in patients whose baseline serum theophylline concentration was under 5ngper ml, when their post‐infusion levels reached 10 to 15 μg per ml. Significant improvement in pulmonary function was noted in subjects whose baseline FEV1was under 50% of the predicted value when their post‐infusion serum theophylline levels rose to 10 to 15 μg

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00387.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractThe recovery periods of serum thyroid stimulating hormone (TSH) were studied in patients with congenital hypothyroidism found on neonatal screening.L‐T4 was administered at 37.8 ± 15.1 days of age (M ± SD), and serum T4, T3, and TSH concentrations were measured. AfterL‐T4 therapy with 10 µg/kg, the serum TSH levels decreased to below 10 µU/ml in five patients within a week, and in another two patients, within two weeks, and in the total number of 12 patients out of 15 (80%), by one month.These results suggest that the recovery of serum TSH occurs rapidly in hypothyroid infants. Thus, the serum TSH concentration may be a good measurement for assessing the adequacy of thyroid hormone therapy from early infancy in patients with congenital hypothy

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00388.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractTo investigate a simplified Master's two‐step test (MTT) for preschool children aged 4 to 6 years exercise tests with new stairs, with risers 18 cm and 20 cm high, were employed. The subjects were 162 preschool children who were divided into four groups according to the height of the riser and the number of steps taken (60 and 72 steps per 3 minutes).In these tests, the 4‐year‐old children obtained similar mean heart rates immediately after exercise (156.9 to 161.6 BPM) in spite of different exercise tests, and the 5‐ and 6‐year‐old children obtained significantly higher mean heart rates (166.0 and 162.1 BPM, respectively) in the test with a 20 cm riser taking 72 steps. If a single protocol is to be used for children aged 4 to 6, the test with a 20 cm riser and taking 72 steps seems to be the best with reference to the achieved heart rates and perform

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00389.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00390.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractFour male siblings including two typical cases of DIDMOAD syndrome are described. The typical cases were aged 16 and 15, with diabetes insipidus, insulin‐dependent diabetes mellitus (IDDM), optic atrophy, perceptive hearing loss, dilatation of the urinary tract and disturbed EEC One of the others was aged 10, with bilateral concentric limitation of the peripheral visual fields, retinal pigment degeneration and disturbed EEG, and the other was aged 6, with IDDM and perceptive hearing loss. The family history revealed complicated parental consanguinity, with some members suffering from diabetes mellitus and deafness. In our cases hereditary transmission seemed to be autosomal recessive, as previously described, and we could not find any association of this syndrome with HL

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1987.tb00391.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY