摘要:

Bias in the evaluation of CNS complications following pertussis immunization are the following: 1) Notifications of postimmunization adverse events, 2) Publications by vaccine producers on the frequency of adverse reactions, 3) Comparison of permanent brain damage after DPT and DT immunization, 4) Pro‐immunization, 5) Immunization associated viral encephalitis, 6) Accuracy of statistics, 7) Personal. A review of these points indicates an underestimation of CNS complications after pertussis immunizatio

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1991.tb02565.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

An Ewing's sarcoma (ES) cell line was established from a metastatic bone marrow specimen in a patient with advanced disease, and some histochemical characteristics were investigated by neuronal differentiation induced with cholera toxin B (CTB) and bromodeoxyuridine (BrdU). Neuronal differentiation was investigated by the expression of neurofilament and Leu‐7, and glial differentiation was observed by expression of S‐100 protein. Neurofilament (NF) and Leu‐7 were positive in ES cells and these were expressed more intensively by induction with CTB than with BrdU. There was no expression of S‐100 protein in untreated or differentiated ES cells. ES cells became differentiated to neuronal cells with CTB and BrdU, but it was not observed, that ES cells had the potential to differentiate to glial cells. It appears that ES is of more primitive neural origin than neuroblastoma, primitive neuroectodermal tumors and other related neural

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1991.tb02566.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Of 50 patients in Thailand suspected clinically of having exanthem subitum, 31 (62%) were serodiagnosed as HHV‐6 infection. Sixteen strains of HHV‐6 from 31 patients (52%) whose antibody titers had converted during convalescence were isolated during the acute phase. The disease occurred in infants from 3 months to 1 year of age and most frequently at age 4‐6 months. Antibody only to HHV‐6 converted in 23 of 50 patients (46%), and seroconversion to HHV‐6 and dengue virus was observed in 7 patients (14%), and to HHV‐6 and Coxsackie B virus in 1 case (2%). In the 23 patients in whom seroconversion only to HHV‐6 was observed, all had fever and rash which appeared after subsidence of the fever. Lymphadenopathy and relative lymphocytosis were recognized, associated with diarrhea, vomiting, running nose, cough and hepatomegaly. Febrile convulsions were seen in some cases. All patients recovered completely

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1991.tb02567.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The prevalence of minor morphological aberrations was evaluated in 54 children with various congenital metabolic disorders. Similarly to major malformations, minor malformations were not more common in the patients than in our control population. The dysmorphic appearance of some of the affected children was caused by minor variants that arose after organogenesis.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1991.tb02568.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The purpose of this paper is to describe the clinical characteristics and significance of the coronary arterial calcification due to Kawasaki disease (KD), based on our five patients. The coronary arterial lesions (CAL) were in segments 1, 2, 5, 6 and 11 according to the classification of the American Heart Association. The interval from the onset to the first appearance of coronary calcification was 17 months to 61 months. Progression of CAL into coronary arterial stenosis or myocardial infarction occurred in all five patients. In the comparative study between the patients with calcified CAL and those with non‐calcified CAL, the maximal size of CAL of the former was 8 mm or larger in contrast with that of the latter (less than 8 mm). It is concluded that coronary arterial calcification is one of the important signs which suggest the presence of the advanced CAL in the follow‐up of children with a history of

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1991.tb02569.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The efficacy of recombinant human erythropoietin (rHuEPO) on 10 anemic children undergoing continuous ambulatory peritoneal dialysis (CAPD) was evaluated. A mean dose of 93 U/kg of rHuEPO was given once a week for 24 weeks, either intravenously to 5 children or subcutaneously to the other 5. Anemia improved in all children by this therapy. The mean hemoglobin and hematocrit levels increased gradually but significantly from 6.9 g/dl and 20.2% to 9.4 g/dl and 30.1%, respectively, at the end of the study. Elevation of blood pressure or other side effects were not noted in any patient. The present study indicates that the once‐a‐week injection of rHuEPO by the intravenous or subcutaneous route is effective in children undergoing C

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1991.tb02570.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

An extensive vaccination program to be used in highly endemic areas is the main strategy against the spreading of hepatitis B. The purpose of this study was the evaluation of the immune response to the recombinant HB vaccine administered singly or at the same time as other compulsory vaccines anti‐diphtheria, anti‐tetanus and oral anti‐polio. Evidence was found of the serological efficacy both of HB vaccine and compulsory vaccines with a percentage of seroconversion of 100%. However, the infants who received HB vaccine at birth and at the age of 1 month had titers of antiHBs higher than the infants who received HB vaccine at birth and at 3 months. No difference in antibody levels of compulsory vaccines was observed among the study groups and the controls who received only compulsory vaccines. Our results suggest that HB vaccination must be encouraged and pursued in all new

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1991.tb02571.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Using dual‐energy x‐ray absorptiometry (DEXA), the lumbar spinal bone mineral density (BMD) in 49 Japanese children with or without metabolic bone disease (MBD) was determined. The following results were obtained: (a) The normal data for healthy Caucasians (J Clin Endocrinol Metab 1990; 70: 1330‐1333) appear to be applicable to Japanese children; (b) BMD was normal in patients with congenital hydronephrosis with normal renal function; (c) One patient with congenital renal failure and one with Lowe syndrome had low BMD, but the MBD in the former improved markedly with peritoneal dialysis; (d) A reduced BMD was found in patients treated with long‐term steroids, probably because of decreased turnover of bone; (e) A reduction in BMD was pronounced in preterm infants during the first few months of life. In conclusion, DEXA is a useful method of bone densitometry in MBD in c

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1991.tb02572.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

To elucidate the incidence and natural history of mitral valve prolapse (MVP) during childhood, we investigated a total of 4,238 children (aged from 1 day to 15 years) classified by age into 4 groups: Group 1:1 to 28‐day‐old full‐term normal newborns (n = 108), Group 2: 6 to 18‐month‐old infants (n = 391), Group 3: 6 to 7‐year‐old children (n = 2,801), and Group 4: 12 to 15‐year‐old children (n = 938). The incidence of MVP was determined by videorecorded two‐dimensional echocardiography in a double‐blind method twice‐over. There were 109 cases diagnosed as having MVP. The incidence rates of MVP were as follows: Group 1: 0%, Group 2: 0.25%, Group 3: 2.1% and Group 4: 5.1%. Arrhythmias were detected in 49% (27/55) by Holter ECG, and by exercise stress test in 4.7% (2/43). Eighty‐three (77%) of 108 cases in Groups 3 and 4, excluding the 1 case in Group 2, showed no symptoms. Ventricular premature contraction (VPC) was the most common arrhythmia, and was benign in all cases. A mid‐systolic click (MSC), late systolic murmur (LSM), MSC + LSM, and a pansystolic murmur were detected in 23.1%, 3.7%, 4.6% and 5.6%, respectively. Symptoms caused by MVP increased and appeared more apparently with age. Further prospective long‐term follow‐up stu

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1991.tb02573.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

A Japanese boy aged 13 months was referred to us because thickened ribs had been observed on a chest X‐ray taken during a respiratory infection. Mucopolysaccharidosis type VI (MPS VI) was diagnosed based on urinary glycosaminoglycan analysis and low activity of arylsulfatase B in peripheral leukocytes. He had mild pupillary membrane remnants, but no corneal opacities. The auditory brainstem response revealed moderate hearing impairment, which may have caused his subnormal DQ score of 85 at the age of 19 months. Although MPS VI is characterized by normal intellectual development with normal hearing in early infancy, it is important to examine for hearing loss, especially when an infant with this disease shows developmental dela

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1991.tb02574.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY