ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1984.tb01804.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1984.tb01805.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1984.tb01806.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

AbstractTo eluidate the development of bile acid metabolism in neonates during the perinatal period, the present author measured the bile acid levels in amniotic fludis and sera of mothers, umbilical cords and neonates. The subjects were 166 samples of amniotic fluids and sera of mothers, umbilical cords and neonates (at 2 days, 1 week, 2 weeks, 3 weeks and 4 weeks of life). The bile acid levels in amniotic fluids were measured by radioimmunoassay (RIA) and the levels in sear were measured by high‐performance liquid chromatography (HPLC).Total chenodeoxycholic acid (unconjugated chenodeoxycholic acid (free CDC), glycochenodeoxycholic acid (GCDCA) and taurochenodeoxycholi acid (TCDCA)) were predominant inamniotic fluidsand sera of early neonates before 1 week of life. Total bile acid (TBA) levels gradually increased for 4 weeks after birth. The mean glycine to taurine (G/T) conjugation ratio of bile acids of mothers was higher than that of umbilical cords and early neonates before 1 week of life. The mean conjugation rate of bile acids in sera of neonates at 1 week after birth was higher than that of mothers and umbilical cords. There were distinct individualities in TBA levels, the presene of lithocholic acid (LCA), total cholic acid to total chenodeoxycholic acid (CA/CDCA) ratio and G/T ratio at the same age, and in bile acid patterns in the same pair of mothers and umbilical cord

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1984.tb01807.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

AbstratInour country, congenital biliary atresia (CBA) has occurred in approximately 1 of 10,000 live births, but its prognosis has been extremely poor. In the mass screening of this disease, glycocholic acid (GCA) or chenodeoxycholic acid (CDCA) level in dried blood spots on filter paper in5‐day‐old neonates was determined by radioimmunoassay (RIA).To determine GCA in dried blood spots on filter paper, the procedures in this experiment were modified using commercial kit for serum.The mean GCA level of controls (n=391) was 5.88±4.28 nM/ml and that of CBA (n=22) was 14.1 ±3.1 nM/ml. On the other hand the mean CDCA level of controls (n=86) was 5.86 ±3.07 pM/l disc that of CBA (n=22) was 30.0 ±35.9 pM/l disc. When the criterion is assumed to be more than 16 nM/ml of GCA level or 10 pM/l disc of CDCA level, false negative diagnoses of CBA are 31.8% and 18.2% respectively. On the other hand false positive diagnoses of CBA are 6.9% and 3.5% respectively. It was thought that false negative diagnosis on mass screening with GCA level would decrease using fresh dried blood spot within 2 weeks after taking blood.In 22 CBA cases, the GCA levels in dried blood spots on filter paper were not always parallel with the CDCA

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1984.tb01808.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

AbstractA study was made on the concentration of taurine in the cord blood, maternal serum, breast milk, urinary excretion and plasme of the same mothers and newborns. The results showed that the taurine content in maternal serum taken within 24 ours of delivery was 117.3 n mol/ml and that of cord blood was 303.5 n mol/ml giving a ratio of 1:2.6. The taurine in breast milk on day 1 and 2 was low but there was a daily increase and on teh 7th day its average became 381.8 n mol/ml.The urinary excretion of taurine in teh newborn was 6,222 n mol/ml before the initial feeding on the 1st day. A gradual decrease was noted and on the 5th day it was 1/15 of tat of the first day.Plasma taurine of the newborn was 186.7 n mol/ml on the first day decreasing to 85.2 n mol/ml on the 5th day.There was a lesser tendency for taurine in the plasma and urine to decrease in the breast fed as compared with those on formulas.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1984.tb01809.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

AbstractIn order to determine the normal size of various branches of the coronary arteries and to clarify the etiological factors that determine the dominant patterns of coronary arteries (dominance) and the relationship between the growth of the coronary arteries and the ventricles, the caliber and the distribution of major coronary arterial branches were measured by selective coronary arteriography in 41 cases with normal hearts and 49 cases with congential heart disease. In normal hearts, the incidences of right dominant(R), balanced(B) and left dominant(L) types were 78%, 15% adn 7%, respectively. In congenital heart disease, the incidences of R, B and L types in right ventricular loading hearts (RV group) were 94%, 0% and 6%, respectively and those in left ventricular loading hearts (LV group) were 58%, 27% and 15%, respectively. The ratios of left main trunk and proximal right corornary in size (LMT/RCA ratio) in RV group weremuch smaller and LMT/RCA ratios in RV group were much larger than those in normal hearts. these results indicated that in the different types of heart anomalies the loading of pressure and volume to the ventricles varies in grade, and subsequently induced the hypertrophy of the loaded parts. It was thought that the resultant hypertrophy also affected the growth and dominance of the coronary arteries.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1984.tb01810.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1984.tb01811.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

AbstractThre newly isolated human rotaviruses in MA104 cells were used as antigens in the neutralization test of paired sera of infants and young children with acute gastroenteritis during three epidemic seasons. Twenty‐three of 41 paired sera (56%) from outpatients with acute gastroenteritis responded with development of NT antibody to one, two, or three antigens. Of 23 paired sera which showed significant rises of antibody to any strain, 20 paired sera (87%) responded to strain Hochi, 15 cases (65%) to strain Ito, and 16 cases (70%) to strain Nemoto. Ten of 14 cases that were seronegative to any isolated strain at onset of illness showed significant rises of antibodies to three strains. Three strains were determined to be subgroup 2 by RNA pattern and were recently found to be similar if not identical to serotype 3 and 4 by Wyatt et al. The neutralization test showed extensive immunologic cross‐reativity among these strains. The rate of acquisition of serum antibody by age was similar with the three antig

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1984.tb01812.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

AbstractThe prevalence of hepatitis B surface antigen (HBs Ag) in various regions of the world is estimated to range from 0.1% to 15%. The area with high prevalence is the west Pacific region. The carrier rate of hepatitis B surface antigen among 1,310 healthy residents in Taegu city, Korea ws investigated in November 1982. Another sample of 729 pregant women and 43 neonates born to HBs Ag‐positive mothers was tested to survey the vertical transmission of HBs Ag between mother and infant from February 1982 to May 1982.Overall prevalence of HBs Ag was 5.6% in 2,039 residents composed of 1,310 inhabitants and 729 pregnant women. The occurrence of HBs Ag was higher in males than females. The correlation between HBs Ag positivity and the socio‐economic status of samples classified into residence, family numbers per room and education level of fathers indicated little of significance but the difference of the HBs AG carrier rate in the group with a surgical history was significantly higher than the group without a surgical history. Acupuncture showed no influence on the HBs Ag carrier rate.43 of 729 pregnant womenad HBs Ag in their sera but none of their neonates were carriers of HBs Ag. Follow‐up tests in 35 infants at 3 months of age and in 32 infants at 6 months of age showed seroconversion to HBs Ag positivity in one infant in each test ‐ but it was the same infant in each case. 31 husbands of HBs Ag ‐ positive women and 20 controls whose wives were HBs Ag ‐ negative were examined. Only one in the control group was a carrier of HBs Ag. These data suggest that close person to person contact transmission of HBV via sexual contact and kissing, etc., are the most probable transmitting modes of HBV if one has sus

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1984.tb01813.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY