摘要:

SummaryThe studies were undertaken to examine changes in glucose‐6‐phosphate dehydrogenase activity during development of human fetal liver and red cells. In the liver, high activity of glucose‐6‐phosphate dehydrogenase was observed through 6 months of gestation. Thereafter, the activity promptly decreased and remained in the range of the adult level. In the red cells, the highest level of enzyme activity was observed during the earliest fetal life. However, the activity of the enzyme in fetal liver was found to be about a thousand times greater than that of the fetal red cells. Accordingly, the high level of glucose‐6‐phosphate dehydrogenase activity in the human phosphate dehydrogenase activity in the human fetal liver may not be a consequence only of contamination by the erythro

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1967.tb02137.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

SummaryStudies on GOT and its isozyme during development of the human fetus were undertaken.Total GOT activity was found to show more striking increases after birth in the heart, liver as well as brain, than during the fetal life. In the heart, increased activity of total GOT after birth resulted from an increase in GOTm rather than from GOTs. In the liver, increase in total GOT activity during development resulted from an increase in the activity of both isozymes, but increases due to GOTm were more predominant. In the brain, increase in activity of both GOTm and GOTs were found to be similar, especially during development after birth.Low activity of GOT during fetal life was found to be attributable to a lack of the protein portion of the transaminase.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1967.tb02138.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

SummaryStudies on fructose diphosphate aldolase during development of the human fetus were undertaken. Additionally, the relation of the activity of LDH and its isozymes to aldolase in developing tissues including the liver, skeletal muscle, heart and brain were observed.In the liver, the activity of aldolase was found to be low throughout pre‐ and postnatal life, while in the skeletal muscle, it was found to increase throughout life. In the heart, aldolase activity was relatively high during 4 to 6 months of gestation, and decreased during the remaining fetal period. No remarkable changes were observed during post‐natal development.The total LDH/aldolase activity ratio was high in the adult liver, while that of the adult muscle was low. During early fetal life these ratios were similar between liver and muscle. With respect to the development of these tissues, the ratio increased in liver and decreased in the muscle. From the finding of changes in this ratio, a critical period in the metabolism during development may be recognized. Such critical periods appeared at the 5th month of gestation in the liver and muscle. Further small changes in the ratio were found to occur only in the muscle at term.During development of the brain, the ratio of total LDH/aldolase decreased, while it increased in the developing heart. Critical periods appear at the 5th month of gestation in the brain and at terminal gestation in the heart.Similar changes were observed in the activity ratios of main component of LDH isozymes to aldolase in all tissues exami

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1967.tb02139.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1967.tb02140.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1967.tb02141.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1967.tb02142.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1967.tb02143.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1967.tb02144.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1967.tb02145.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1967.tb02146.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY