ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1981.tb01525.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

One hundred and seventeen patients undergoing operations on the head and neck were investigated for the causes of infection. There was a close relationship between the pre‐operative culture and the risk of infection. There was a greater risk of infection (10.7%) when the pharynx was opened than when it was not (0.0%). The operations most liable to infection are laryngopharyngectomy and those in which skin flaps are used. The isolation of pathogenic bacteria in the operative exudate did not in general predispose to the development of infection, which did not occur when these cultures were negative. Positive cultures obtained from the drain on 3 consecutive days were a significant indication that infection will probably occu

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1981.tb01526.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

An attempt was made to trace 511 men and women who manufactured mustard gas during the 1939‐1945 war. Despite limitations in the identifying data available, 428 (84%) were traced to the end of 1974. The numbers of deaths from all neoplasms combined (45) and from all other causes (136) were slightly greater than those expected from national death rates, but not significantly so. Two deaths were attributed to carcinoma of the larynx and one to carcinoma of the trachea, compared with an expected number of 0.40 (P<0.02). Carcinoma of the larynx was also mentioned on the death certificate of another man. Seven subjects are known to have developed cancer of the larynx, compared with 0.75 expected (P<0.001). Excess mortality was also observed from cancer of the lung, pneumonia and accidents, but the excesses were small and difficult to interpre

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1981.tb01527.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Thirty‐six patients with laryngeal carcinoma were investigated by computerized tomography (CT). In 8 patients invasion of cartilage was shown at subsequent pathological examination of the excised larynges. In all there were 14 areas of cartilage involvement, II of which could be diagnosed on retrospective examination of the CT scans. Involvement of tumour was shown either as areas of decreased density (chondrolysis) or areas of local increased density (chondrosclerosis) due to cartilage ossification. False positive and false negative evidence of cartilage involvement was recorded in the series, but the accuracy of diagnosis in positive terms was approximately 79%. Histological evidence is put forward that the presence of carcinoma in relation to the cartilage produces perichondritis, which enhances ossification and the latter process may then in itself facilitate invasion by the tumour. Previous radiotherapy may also be a factor in the causation of the perichondritis and ossificatio

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1981.tb01528.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The paper contains the results of light microscopical, electron microscopical and histochemical examinations of chronic otitis media, with and without cholesteatoma, with special focus on the problems regarding bone resorption. It is demonstrated that bone resorption takes place without the presence of cholesteatoma itself, even though the magnitude of resorption is higher in the cases with cholesteatoma. It is demonstrated that there is always a layer of subepithelial granulation tissue between the cholesteatoma membrane and the underlying bone. The picture in the resorbing zone is dominated by mononuclear histiocyte like cells, containing dense cytoplasmatic bodies, called lysosomes, and it is demonstrated that the marker enzyme for acid hydrolases, the acid phosphatase, is present in large quantities, both in the histiocytes, as well as spread along the bony surface. It is concluded that a possible mechanism for bone resorption is performed by the acid hydrolases, contained in the histiocytes, working at acid pH. It is noteworthy that the multinucleated osteoclast is not demonstrated in the resorbing margin of bone and that the picture is dominated by capillary proliferation, indicating that ischemia does not play a role in bone resorption. On the contrary, this is in the author's opinion caused by inflammation and hyperemia. The various factors influencing bone resorption in general and in chronic otitis media are discussed and a new model for studying cholesteatoma pathology in the middle ear is presented.

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1981.tb01529.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Proplast and PlastiporeSixteen Proplast and 52 Plastipore prostheses, removed at revision surgery, have been examined histologically and the findings illustrated. The macroscopic appearance of the prostheses was preserved. Fibrous tissue capsule formation was common. It has been expected that the prostheses will be invaded by fibrous tissue and thereby stabilized. Fibrous tissue ingrowth was consistently seen in Proplast but not Plastipore prostheses. Multinucleared foreign body giant cells were present in large numbers in both types. There was histological evidence of breakdown of the prostheses.

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1981.tb01530.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Our experiences with aluminium oxide ceramic implants which were designed to reconstruct the ossicular chain are reported. The properties of this bioinert ceramic, the handling of the 4 prototypes and the indications for their use are described. Our preliminary clinical results–since 1978–are repor

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1981.tb01531.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Five cases of primary carcinoma of the trachea are summarized together with a review of 97 cases recorded at the Birmingham Cancer Registry between 1957 and 1974. Squamous cell carcinoma is the most frequent type (46.4%) followed by anaplastic and oat cell carcinoma (18.5%). The annual incidence rate is 0.15 per 100 000 in males and 0.06 per 100 000 in females. The mean age at presentation is 60.08 years and 63.89 years for males and females respectively. Although there has been an increase in the number of cases reported over this period, the increase in larynx (43%) and trachea (50%) has not kept pace with that for bronchial carcinoma (85%). Some experimental studies in animals and the results of treatment in 97 cases from the Cancer Registry are reported. A brief summary of methods of treatment for carcinoma of the trachea is included. In suitable cases, primary surgery with direct anastomosis offers the best survival rates, although the overall survival rate is poor.

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1981.tb01532.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Twenty‐two patients with squamous carcinoma of the nasal vestibule are reported. If a sufficiently large volume of tissue is irradiated, radiotherapy is to be preferred to surgery as the primary form of treatment on cosmetic grounds. Local recurrence can be treated successfully by surgery and the ultimate prognosis remains good. The prognosis is very unfavourable if regional lymph node metastases appear. We propose that all patients should undergo an ipsilateral suprahyoid neck dissection to identify occult nodes. If these are found radical radiotherapy should be give

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1981.tb01533.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1981.tb01534.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY