ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1992.tb01697.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1992.tb01698.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTOne hundred patients, aged 13‐79 years, have undergone 195 endoscopic ‘ethmoidectomies’. The operative method was entirely based upon the Messerklinger technique. In this study there were two main groups.(1) Patients with moderate to massive nasal/endonasal polyposis.(2) Patients with recurrent sinusitis.In the second group, the preoperative endoscopic findings were dominated by disease in the middle meatus and in the area of the anterior ethmoid, verified either by conventional hypocycloidal or computed tomography.Close to 90% of the patients were treated on an out‐patient basis, under local anaesthesia.No serious peroperative complications (major bleeding, CSF leak, or visual problems) have been encountered. Thorough and meticulous post‐operative care to avoid adhesions and renewed ostiomeatal obstruction, is felt to be important.The mean follow‐up was 14 months.The post‐operative results are encouraging, and correspond to larger European and American reports. The Messerklinger technique has proved to be suitable for smaller ENT departments, such as ours, especially as the patients can be treated on an out‐patient basis using local/topi

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1992.tb01699.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTThe traditional method of classifying perennial rhinitis into eosinophilic and non‐eosinophilic is by taking a single nasal smear from one nostril. In the light of personal experience it was felt that this method of sampling may be inadequate. The present study included 20 patients with perennial rhinitis undergoing nasal surgery. Serum total IgE levels were taken and those above 40 IU/ml had allergen specific IgE measured. Nasal smears and biopsies were taken from 5 sites on each side of the nose: middle and inferior turbinates and post nasal space. The smears significantly correlated with the biopsies (rs= 0.446, P<0.001). The distribution of eosinophils between and within nasal cavities was found to differ. Representative sampling of the nose is important for accurate eosinophil expression. The definition of an eosinophil rich and poor nose requires greater clarification as it has great clinical relevance regarding managemen

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1992.tb01700.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTThe purpose of this evaluation is to compare whether retention of auricular prostheses, through utilization of osseointegrated implants rather than by adhesives, provides any improvement in patient acceptance and prosthesis longevity. Forty‐seven out of a total of 49 patients having facial prostheses, retained by means of Brånemark fixtures, were surveyed. Ease of retention was noted in 91% of the patients. Satisfaction with the shape of the prosthesis, colour and ease of positioning was 100, 85 and 98% respectively. None of the patients experienced skin irritation under the prosthesis and 94% of them wore their prosthesis daily. Of the 13 patients with previous prosthesis experience, 92% stated improved retention and all of them found ease of positioning and wearing comfort had improved. Durability was better in 62%, unchanged in 23% and worse in 15% of these 13 patien

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1992.tb01701.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTThe results of a prospective study of 121 latissimus dorsi flaps performed during head and neck reconstructive surgery at the Royal Marsden Hospital are presented. Three‐quarters of the flaps were pedicled and one‐quarter were free. All the patients underwent surgery for malignant disease. The flap failure rate was 5%, other flap related complications occurred in 19% and the overall rate of complications was 26%. Previous radiotherapy, site of reconstruction, type of flap (free or pedicled) and age of the patient were not significant risk factors. Men were more likely to have a complication than wo

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1992.tb01702.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTMiddle car mucosal biopsies could be maintained in culture for up to 7 days, the longest time attempted in this study. Mucin biosynthesis and secretion were measured by incorporation of14C‐glucosamine. Three peaks of radioactivity were present when the dialysed medium was chromatographed. Peak I which accounted for about 10% of the total radioactivity had properties characteristic of mucin. The other two peaks were not characteristic of mucins. Labelled macromolecules excluded on Sepharose 2B were also present in the tissue. Autoradiography of the explants showed that the labelled glucosamine was concentrated in the epithelial layer. Morphometry demonstrated that 1–2% of the epithelial cell volume consisted of goblet cells. The proportionate incorporation of radioactivity into macromolecules increased with increasing epithelial cell volume. This system will allow assessment of factors implicated in the pathogenesis of otitis media with effusion and the study of the action of pharmacological agents on biosynthesis and secret

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1992.tb01703.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTWe present a prospective analysis of the lung function of 22 patients with unilateral vocal cord paralysis before and after Teflon injection. In the majority of patients the vocal cord paralysis was caused by an underlying malignant condition. Full spirometric and flow‐volume loop studies demonstrated an increase in airway resistance after Teflon injection which was not clinically evident. The improvement in symptom score for aspiration was greater than that for dysphonia. Keywords unilateral vocal cord paralysis Teflon injection airway resistan

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1992.tb01704.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTForty patients with end‐stage carcinoma of the head and neck were admitted to a randomized double blind trial with cisplatinum in one arm and cisplatinum + nifedipine in the other.Nifedipine, a calcium channel blocking drug, inhibits the effect of acquired multidrug resistance in animal models.In the present study the addition of this agent had no effect on either response rate or survival in end‐stage carcinoma of the head and neck.It is concluded that adding nifedipine to cisplatinum serves no useful purpose in the treatment of end‐stage carcinoma of the head and

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1992.tb01705.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

ABSTRACTOpen cavity mastoidectomy remains the principal surgical treatment of middle ear cholesteatoma in the United Kingdom. A significant proportion of mastoid cavities are prone to intermittent or continuous discharge.In this study the histopathological features of material removed from 159 mastoid cavities at revision surgery were reviewed. Findings included squamous epithelium with acute and chronic inflammation, foreign body granuloma and aural polyps. Of particular note was the very infrequent finding of discharging cavities lined with respiratory epithelium, suggesting that retained mucosa in mastoid air cells is not a common cause of persistent otorrhoea.

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1992.tb01706.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY