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| 11. |
Immunogenicity, safety and tolerability of varying doses and regimens of inactivated hepatitis A virus vaccine in Navajo children |
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The Pediatric Infectious Disease Journal,
Volume 13,
Issue 7,
1994,
Page 640-642
WENDY NEWCOMER,
BETH RIVIN,
RAYMOND REID,
LAWRENCE MOULTON,
MARK WOLFF,
JANNE CROLL,
CAROL JOHNSON,
LEORA BROWN,
DAVID NALIN,
MATHURAM SANTOSHAM,
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摘要:
The Navajo are known to be at high risk for hepatitis A virus (HAV) infection. This study investigated the safety and immunogenicity of an investigational, alum-adjuvanted, formalin-inactivated HAV vaccine (VAQTA) developed by Merck Research Laboratories in Navajo children. One hundred two of 212 children, ages 4 to 12 years, were HAV-seronegative (<10 mIU/ml by an enhanced sensitivity modification of the HAVAB*; Abbott). Ninety of these children received the HAV vaccine. Study participants were given vaccines containing various viral protein concentrations: Group A (n= 18), 6 units; Group B (n= 36), 13 units; and Group C (n= 36), 25 units HAV protein (1 unit ± 1 ng viral protein antigen). Three-dose (0, 8, 24 weeks) and two-dose (0, 24 weeks) regimens were compared in subgroups within B and C. The vaccine was well-tolerated and there were no serious adverse reactions; no vaccinee developed hepatitis A. After 1 dose 82 to 100% of children seroconverted (≥10 mIU/ml, modified HAVAB*; Abbott) and 100% seroconverted after 2 doses. After 1 dose the geometric mean titer for antibody was: Group A, 22 mIU/ml; Group B, 18 mIU/ml; and Group C, 38 mIU/ml. After 3 doses geometric mean titers increased to 10 106 mIU/ml in Group A, 7258 mIU/ml in Group B and 11 856 mIU/ml in Group C. Further field studies are indicated to evaluate its use in high risk populations, such as the Navajo.
ISSN:0891-3668
出版商:OVID
年代:1994
数据来源: OVID
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| 12. |
Virus‐induced neutrophil dysfunctionrole in the pathogenesis of bacterial infections |
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The Pediatric Infectious Disease Journal,
Volume 13,
Issue 7,
1994,
Page 643-652
JON ABRAMSON,
J. WHEELER,
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ISSN:0891-3668
出版商:OVID
年代:1994
数据来源: OVID
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| 13. |
Infections of the ear with nontuberculous mycobacteria in three children |
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The Pediatric Infectious Disease Journal,
Volume 13,
Issue 7,
1994,
Page 653-656
OLLE NYLÉN,
KJELL ALESTIG,
ANDERS FASTH,
NILS GUSTAVII,
JAN OLOFSSON,
ULF RENVALL,
ANDERS TJELLSTRÖM,
PER WÅHLÉN,
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PDF (381KB)
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ISSN:0891-3668
出版商:OVID
年代:1994
数据来源: OVID
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| 14. |
EVALUATION OF THE ROLE OF HEPATITIS C VIRUS IN BILIARY ATRESIA |
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The Pediatric Infectious Disease Journal,
Volume 13,
Issue 7,
1994,
Page 657-658
H. Kader,
M. Nowicki,
K. Kuramoto,
B. Baroudy,
J. Zeldis,
W. Balisteri,
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ISSN:0891-3668
出版商:OVID
年代:1994
数据来源: OVID
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| 15. |
TEMPORAL DEVELOPMENT OF ACUTE OTITIS MEDIA DURING UPPER RESPIRATORY TRACT INFECTION |
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The Pediatric Infectious Disease Journal,
Volume 13,
Issue 7,
1994,
Page 659-660
Terho Heikkinen,
Olli Ruuskanen,
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PDF (322KB)
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ISSN:0891-3668
出版商:OVID
年代:1994
数据来源: OVID
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| 16. |
C4B ISOTYPE DEFICIENCY IN HAEMOPHILUS INFLUENZAE TYPE b AND MENINGOCOCCAL MENINGITIS |
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The Pediatric Infectious Disease Journal,
Volume 13,
Issue 7,
1994,
Page 661-661
E. Goddard,
P. Creemers,
D. Beatty,
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ISSN:0891-3668
出版商:OVID
年代:1994
数据来源: OVID
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| 17. |
MILD HERPES SIMPLEX ENCEPHALITIS DIAGNOSED BY POLYMERASE CHAIN REACTIONA CASE REPORT AND REVIEW |
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The Pediatric Infectious Disease Journal,
Volume 13,
Issue 7,
1994,
Page 662-663
John DeVincenzo,
Grace Thorne,
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PDF (345KB)
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ISSN:0891-3668
出版商:OVID
年代:1994
数据来源: OVID
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| 18. |
CONGENITAL ADENOVIRAL INFECTION |
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The Pediatric Infectious Disease Journal,
Volume 13,
Issue 7,
1994,
Page 664-666
Chen-Chia Chiou,
Wen-Jue Soong,
Betau Hwang,
Keh-Gong Wu,
Bor-Huey Lee,
Hsin-Chih Wang,
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ISSN:0891-3668
出版商:OVID
年代:1994
数据来源: OVID
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| 19. |
SEQUENTIAL DEVELOPMENT OF ACUTE MENINGOENCEPHALITIS AND TRANSVERSE MYELITIS CAUSED BY EPSTEIN‐BARR VIRUS DURING INFECTIOUS MONONUCLEOSIS |
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The Pediatric Infectious Disease Journal,
Volume 13,
Issue 7,
1994,
Page 667-668
Hiroyuki Tsutsumi,
Hodaka Kamazaki,
Shuji Nakata,
Masayoshi Nagao,
Shunzo Chiba,
Shosuke Imai,
Toyoro Osato,
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PDF (340KB)
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ISSN:0891-3668
出版商:OVID
年代:1994
数据来源: OVID
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| 20. |
EVALUATION OF PROPHYLAXIS AGAINST INVASIVE PNEUMOCOCCAL INFECTIONS IN HUMAN IMMUNODEFICIENCY VIRUS‐INFECTED CHILDREN |
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The Pediatric Infectious Disease Journal,
Volume 13,
Issue 7,
1994,
Page 669-670
Vicki Peters,
Alexander Hyatt,
Clyde Schechter,
Esther Diamant,
David Hodes,
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PDF (333KB)
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ISSN:0891-3668
出版商:OVID
年代:1994
数据来源: OVID
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