ISSN:0952-7907    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

The fact that drugs may exist in stereoisomeric forms with potentially different pharmacodynamic and pharmacokinetic properties has been a neglected aspect in anaesthesiology. This review provides a basic introduction and examples of both theoretical and practical relevance to this topic.

ISSN:0952-7907    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

This article reviews the drug interactions and the basic pharmacology, pharmacokinetics and pharmacodynamics of the proton pump inhibitor omeprazole. It will cover side effects, including hypergastrinaemia and possible genotoxicity. The recent clinical applications of omeprazole are also reviewed, with particular reference to areas relevant to anaesthesia and intensive care.

ISSN:0952-7907    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

This review is designed to update the clinician regarding the general molecular pharmacology of receptors. We discuss receptor systems currently of interest to practicing anesthesiologists, as well as receptor systems that may become important in the future.

ISSN:0952-7907    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

There has been much research into novel routes of drug delivery as well as novel dosage regimens using conventional routes. Development and assessment of these regimens should be based on pharmacokinetic and pharmacodynamic principles familiar to anaesthesiologists. These approaches may allow easier continuation of concurrent medication in the perioperative period and administration of analgesic, sedative, anaesthetic and vasoactive drugs as well as neuromuscular-blocking agents in anaesthesia and intensive therapy.

ISSN:0952-7907    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

This review describes adverse drug reactions (ADRs) reported for 1990, with particular emphasis on: firstly, the adverse reactions to cyclosporine, a drug whose use has so greatly enhanced long-term survival after organ transplantation and has proved beneficial in many autoimmune diseases with the result that anaesthetists frequently encounter patients receiving this drug; and secondly, torsade de pointes, a ventricular tachyarrhythmia that is often drug related, e.g. secondary to terfanadine, haloperidol, and ketanserin.

ISSN:0952-7907    

出版商:OVID    

年代:1991

数据来源: OVID

ISSN:0952-7907    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

Volatile anesthetics exert important effects on many cellular and organ system metabolic parameters. Although insight about cell membrane changes have been complemented by studies of interactions with specific neurotransmitters and cellular calcium dynamics, a clear picture of the mechanisms responsible for anesthesia remains elusive. It is very fortunate that lack of total understanding does not preclude the safe and effective delivery of an anesthetic.

ISSN:0952-7907    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

The lower the hepatotoxic potential of modern inhalation anaesthetics, the lower their degree of metabolism. Thus, in contrast to halothane, little hepatotoxicity, or none at all, is expected from the clinical use of isoflurane, desflurane, N2O and xenon. Despite the fact that N2O inhibits methionine synthase, clinically significant bone marrow failure is a rare side effect even after long N2O exposure.

ISSN:0952-7907    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

Research published over the last 12 months investigating the practical application of techniques of total intravenous anaesthesia (TIVA) is reviewed. Specific topics addressed are dose requirements for propofol infusion in adults and children, computerized delivery systems, pharmaco-kinetics, cardiovascular and intracranial effects, and obstetric and paediatric application of TIVA.

ISSN:0952-7907    

出版商:OVID    

年代:1991

数据来源: OVID