摘要:

The purpose of this review is to describe in more detail ischemia reperfusion injury and preconditioning, and to speculate on the potential role of preconditioning in the care of critically ill patients. Current hemodynamic treatment of hypotension and hypoperfusion in critically ill patients is directed at ensuring essential organ perfusion by maintaining intravascular volume and cardiac output, and ensuring adequate oxygen delivery by maintaining arterial oxygen partial pressure and hemoglobin levels. However, morbidity and mortality remain high and new approaches to critically ill patients are required. Treatments are needed that can protect against organ ischemia during periods of low blood flow. In recent years, there has been a growing appreciation of the importance of ischemia reperfusion injury. Ischemia associated with reperfusion may result in greater injury than ischemia alone. Ischemic preconditioning is used to describe the protective effect of short periods of ischemia to an organ or tissue against longer periods of ischemia. Although first described in the myocardium, there is now evidence that this phenomenon occurs in a wide variety of organs and tissues, including the brain and other nervous tissue such as the retina and spinal cord, liver, stomach, intestines, kidney, and the lungs. Preconditioning therapy may offer a new avenue of treatment in critically ill patients. Both traditional preconditioning methods and pharmacologic agents that mimic or induce such preconditioning may be used in the future. Clinical trials of pharmacologic agents are underway in patients with coronary artery disease. Further trials of such methods and agents are needed in critically ill patients suffering from sepsis or multiorgan system failure.

ISSN:0952-7907    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Most efforts to identify and investigate errors in medicine have focused on active failures and general provider behaviors. We believe that the greatest improvements in error identification and management in the intensive care unit will be achieved by focusing on the intensive care unit's organizational characteristics. The results of three recent studies suggest that differences in intensive care unit organizational characteristics are significantly related to variation in the risk-adjusted morbidity and mortality. Physicians must assume greater leadership in creation of these safe systems for intensive care patients. We encourage the creation of multiinstitutional communities to work collaboratively to advance patient safety in high-risk environments like the intensive care unit.

ISSN:0952-7907    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Ventilator-associated pneumonia is the most serious infectious complication in critically ill patients, associated with increased length of intensive care unit treatment and high mortality rates. Investigations focused on outcome variables have improved the database to estimate diagnostic and therapeutic management strategies. This knowledge has diminished the importance of the discussion on how to diagnose the pneumonia. This review summarizes recent data on epidemiology and mortality, risk factors and prevention, diagnosis, microbiology and antimicrobial treatment of ventilator-associated pneumonia.

ISSN:0952-7907    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

The goal of mechanical ventilation in patients with acute lung injury is to support gas exchange and mitigate ventilator-associated lung injury. High-frequency oscillatory ventilation relies on the generation of a constant distending pressure, small tidal volumes and rapid respiratory rates with the intent to recruit atelectatic lung, reduce peak inflating pressures and limit volutrauma. The utilization of high-frequency oscillatory ventilation has dramatically increased in neonatal and pediatric intensive care units. As there is an overlap between the intensive care unit and the operating room, anesthesiologists must be familiar with recent advances in the care of infants and children with acute respiratory failure. High-frequency oscillatory ventilation has been used successfully to manage patients with severe respiratory failure who have failed conventional mechanical ventilation. When initiated early, high-frequency oscillatory ventilation has been shown to improve oxygenation and reduce acute and chronic lung injury in neonates, infants and children. Further trials are necessary to better delineate the benefits and risks of this therapy in various patient populations.

ISSN:0952-7907    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Disability from traumatic injury is on the increase worldwide. Dogma rather than scientific evidence has tended to be responsible for determining the treatment of major trauma victims. Evidence is now beginning to emerge, however, questioning the dogma, and suggesting that different treatment options may yield better outcomes. This review examines the recent literature in resuscitation for major trauma.

ISSN:0952-7907    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Current reviews and consensus documents now recommend a more discriminating approach to the traditional practices of delivering liberal infusions of intravenous fluid to all major trauma patients with suspected or known major hemorrhage. The evolving evidence suggests that aggressive fluid resuscitation prior to hemostasis leads to additional bleeding through hydraulic acceleration of hemorrhage, soft clot dissolution, and dilution of clotting factors. Aggressive preoperative fluid infusion is still considered appropriate for unconscious patients without palpable blood pressure or for those with controllable hemorrhage (e.g. isolated extremity or head injury), However, the latest recommendations are to limit or delay intravenous fluid resuscitation preoperatively in those with uncontrollable hemorrhage (e.g. those with penetrating torso injuries), even if they are hypoperfusing. Although most clinicians still generally support fluid resuscitation for multisystem blunt trauma, particularly with head injury, the most recent experimental data have begun to challenge this traditional practice as well, suggesting a ‘slow infusion’ approach when there is risk for uncontrolled internal bleeding. By providing oxygen delivery with slow, limited infusion, new hemoglobin-based oxygen carriers might help to resolve the current dilemma of having to limit preoperative resuscitation when there is risk of uncontrolled hemorrhage.

ISSN:0952-7907    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

The administration of allogeneic red blood cell transfusions to the trauma patient is an essential and potentially life-saving component of trauma care. The big question is when to transfuse, and how much? In this review, we explore the evidence and provide rationales for current and future red blood cell transfusion strategies in the trauma patient. We also discuss the changing trends and competing risks associated with transfusions as well as current evidence for different blood conservation strategies in the context of trauma.

ISSN:0952-7907    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Trauma has a significant impact on pediatric morbidity and mortality. Depending on the emergency medical services and health care system, anesthesiologists may be involved in pediatric trauma care at the scene, in the emergency department, in the operating room, or in the intensive care unit. Familiarity with the pathophysiology of pediatric trauma and age-dependent anatomical and physiological features is, therefore, essential to every anesthesiologist. Fast and appropriate interventions with respect to the clinical status and the suspected injuries are the key to successful treatment. Due to the high incidence of head injury, airway management and hemodynamic stabilization are of utmost importance. For preclinical trauma care, however, evidence-based data showing a gold standard for pediatric trauma care are still lacking.

ISSN:0952-7907    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Cervical spine injuries occur in 2-5% of blunt trauma patients, and 1-5% of these injuries are initially missed. Data from the large National Emergency X-Radiography Utilisation Study have helped to define the problem in some detail. There is a consensus on how to clear the cervical spine in patients who are alert, but in patients with altered mental status the choice of strategy for spinal clearance is more controversial. Despite obtaining extensive radiological studies, some clinicians will not clear the patient's cervical spine until full recovery of consciousness. As long as manual in-line neck stabilization is applied, rapid sequence induction of anaesthesia, followed by direct laryngoscopy and oral intubation appears to be safe in the patient with a cervical spine injury. If intubation is not urgent, an awake fibreoptic technique is a useful option. If intubation of the patient with a potential cervical spine injury fails, or appropriate experienced personnel are unavailable, the laryngeal mask airway or one of its various modifications are useful alternatives.

ISSN:0952-7907    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

‘Suspended animation for delayed resuscitation’ is a new concept for attempting resuscitation from cardiac arrest of patients who currently (totally or temporarily) cannot be resuscitated, such as traumatic exsanguination cardiac arrest. Suspended animation means preservation of the viability of brain and organism during cardiac arrest, until restoration of stable spontaneous circulation or prolonged artificial circulation is possible. Suspended animation for exsanguination cardiac arrest of trauma victims would have to be induced within the critical first 5 min after the start of cardiac arrest no-flow, to buy time for transport and resuscitative surgery (hemostasis) performed during no-flow. Cardiac arrest is then reversed with all-out resuscitation, usually requiring cardiopulmonary bypass. Suspended animation has been explored and documented as effective in dogs in terms of long-term survival without brain damage after very prolonged cardiac arrest. In the 1990s, the Pittsburgh group achieved survival without brain damage in dogs after cardiac arrest of up to 90 min no-flow at brain (tympanic) temperature of 10°C, with functionally and histologically normal brains. These studies used emergency cardiopulmonary bypass with heat exchanger or a single hypothermic saline flush into the aorta, which proved superior to pharmacologic strategies. For the large number of normovolemic sudden cardiac death victims, which currently cannot be resuscitated, more research in large animals is needed.

ISSN:0952-7907    

出版商:OVID    

年代:2002

数据来源: OVID